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Noncoding Transcriptional Landscape in Human Aging

  • Marina C. Costa
  • Ana Lúcia Leitão
  • Francisco J. Enguita
Chapter
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 394)

Abstract

Aging is a universal phenomenon in metazoans, characterized by a general decline of the organism physiology associated with an increased risk of mortality and morbidity. Aging of an organism correlates with a decline in function of its cells, as shown for muscle, immune, and neuronal cells. As the DNA content of most cells within an organism remains largely identical throughout the life span, age-associated transcriptional changes must be achieved by epigenetic mechanisms. However, how aging may impact on the epigenetic state of cells is only beginning to be understood. In light of a growing number of studies demonstrating that noncoding RNAs can provide molecular signals that regulate expression of protein-coding genes and define epigenetic states of cells, we hypothesize that noncoding RNAs could play a direct role in inducing age-associated profiles of gene expression. In this context, the role of long noncoding RNAs (lncRNAs) as regulators of gene expression might be important for the overall transcriptional landscape observed in aged human cells. The possible functions of lncRNAs and other noncoding RNAs, and their roles in the regulation of aging-related cellular pathways will be analyzed.

Keywords

Noncoding RNAs Senescent Cell Replicative Senescence Molecular Damage Natural Antisense Transcript 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer International Publishing Switzerland 2015

Authors and Affiliations

  • Marina C. Costa
    • 1
  • Ana Lúcia Leitão
    • 2
  • Francisco J. Enguita
    • 1
  1. 1.Instituto de Medicina Molecular, Faculdade de MedicinaUniversidade de Lisboa, Av. Professor Egas MonizLisbonPortugal
  2. 2.Departamento de Ciências e Tecnologia da Biomassa, Faculdade de Ciências e TecnologiaUniversidade Nova de Lisboa, Quinta da TorreCaparicaPortugal

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