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Noncoding Transcriptional Landscape in Human Aging

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Long Non-coding RNAs in Human Disease

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 394))

Abstract

Aging is a universal phenomenon in metazoans, characterized by a general decline of the organism physiology associated with an increased risk of mortality and morbidity. Aging of an organism correlates with a decline in function of its cells, as shown for muscle, immune, and neuronal cells. As the DNA content of most cells within an organism remains largely identical throughout the life span, age-associated transcriptional changes must be achieved by epigenetic mechanisms. However, how aging may impact on the epigenetic state of cells is only beginning to be understood. In light of a growing number of studies demonstrating that noncoding RNAs can provide molecular signals that regulate expression of protein-coding genes and define epigenetic states of cells, we hypothesize that noncoding RNAs could play a direct role in inducing age-associated profiles of gene expression. In this context, the role of long noncoding RNAs (lncRNAs) as regulators of gene expression might be important for the overall transcriptional landscape observed in aged human cells. The possible functions of lncRNAs and other noncoding RNAs, and their roles in the regulation of aging-related cellular pathways will be analyzed.

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Authors and Affiliations

  1. Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Av. Professor Egas Moniz, 1649-028, Lisbon, Portugal

    Marina C. Costa & Francisco J. Enguita

  2. Departamento de Ciências e Tecnologia da Biomassa, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Quinta da Torre, Campus de Caparica, 2829-516, Caparica, Portugal

    Ana Lúcia Leitão

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  1. Marina C. Costa
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  2. Ana Lúcia Leitão
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  3. Francisco J. Enguita
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  1. City of Hope - Beckman Research Institute, Center for Gene Therapy City of Hope-Beckman Research Institute, Duarte, California, USA

    Kevin V. Morris

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Costa, M.C., Leitão, A.L., Enguita, F.J. (2015). Noncoding Transcriptional Landscape in Human Aging. In: Morris, K. (eds) Long Non-coding RNAs in Human Disease. Current Topics in Microbiology and Immunology, vol 394. Springer, Cham. https://doi.org/10.1007/82_2015_460

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