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Theoretical Models of Generalized Quasispecies

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Quasispecies: From Theory to Experimental Systems

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 392))

Abstract

Theoretical modeling of quasispecies has progressed in several directions. In this chapter, we review the works of Emmanuel Tannenbaum, who, together with Eugene Shakhnovich at Harvard University and later with colleagues and students at Ben-Gurion University in Beersheva, implemented one of the more useful approaches, by progressively setting up various formulations for the quasispecies model and solving them analytically. Our review will focus on these papers that have explored new models, assumed the relevant mathematical approximations, and proceeded to analytically solve for the steady-state solutions and run stochastic simulations . When applicable, these models were related to real-life problems and situations, including changing environments, presence of chemical mutagens, evolution of cancer and tumor cells , mutations in Escherichia coli, stem cells , chromosomal instability (CIN), propagation of antibiotic drug resistance , dynamics of bacteria with plasmids , DNA proofreading mechanisms, and more.

In memory of Prof. Emmanuel David Tannenbaum (1978–2012).

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Authors and Affiliations

  1. Department of Chemistry, Ben-Gurion University of the Negev, Beer Sheva, 84105, Israel

    Nathaniel Wagner, Yoav Atsmon-Raz & Gonen Ashkenasy

Authors
  1. Nathaniel Wagner
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  2. Yoav Atsmon-Raz
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  3. Gonen Ashkenasy
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Corresponding author

Correspondence to Gonen Ashkenasy .

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Editors and Affiliations

  1. Campus de Cantoblanco, Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Madrid, Spain

    Esteban Domingo

  2. The Santa Fe Institute, Santa Fe, NM, USA and Institut f. Theoretische Chemie, Universität Wien, Vienna, Austria

    Peter Schuster

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Wagner, N., Atsmon-Raz, Y., Ashkenasy, G. (2015). Theoretical Models of Generalized Quasispecies. In: Domingo, E., Schuster, P. (eds) Quasispecies: From Theory to Experimental Systems. Current Topics in Microbiology and Immunology, vol 392. Springer, Cham. https://doi.org/10.1007/82_2015_456

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