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The Past, Present, and Future of NK Cells in Hematopoietic Cell Transplantation and Adoptive Transfer

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Natural Killer Cells

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 395))

Abstract

Hematopoietic cell transplantation (HCT) has been used as a part of cancer therapy for over half a decade. Beyond the necessity for donor-derived cells to reconstitute hematopoiesis after radiation and chemotherapy, immunologic reconstitution from allogeneic cells is important for the elimination of residual tumor cells. Natural killer (NK) cells are first among lymphocytes to reconstitute post-transplant and protect against cancer relapse. In this review, we provide a historical perspective on the role of NK cells in cancer control in the transplant setting and focus on current research aimed at improving NK cell responses for therapeutic benefit.

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References

  • Appelbaum FR, Dahlberg S, Thomas ED et al (1984) Bone marrow transplantation or chemotherapy after remission induction for adults with acute nonlymphoblastic leukemia. A prospective comparison. Ann Intern Med 101(5):581–588

    Article  CAS  PubMed  Google Scholar 

  • Arase H, Mocarski ES, Campbell AE, Hill AB, Lanier LL (2002) Direct recognition of cytomegalovirus by activating and inhibitory NK cell receptors. Science 296(5571):1323–1326

    Article  CAS  PubMed  Google Scholar 

  • Ardolino M, Azimi CS, Iannello A et al (2014) Cytokine therapy reverses NK cell anergy in MHC-deficient tumors. J Clin Invest 124(11):4781–4794

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Bachanova V, Burns LJ, McKenna DH et al (2010) Allogeneic natural killer cells for refractory lymphoma. Cancer Immunol Immunother 59(11):1739–1744

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Bachanova V, Cooley S, Defor TE et al (2014) Clearance of acute myeloid leukemia by haploidentical natural killer cells is improved using IL-2 diphtheria toxin fusion protein. Blood 123(25):3855–3863

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Beck JC, Wagner JE, DeFor TE et al (2010) Impact of cytomegalovirus (CMV) reactivation after umbilical cord blood transplantation. Biol Blood Marrow Transplant 16(2):215–222

    Article  PubMed Central  PubMed  Google Scholar 

  • Behrendt CE, Rosenthal J, Bolotin E, Nakamura R, Zaia J, Forman SJ (2009) Donor and recipient CMV serostatus and outcome of pediatric allogeneic HSCT for acute leukemia in the era of CMV-preemptive therapy. Biol Blood Marrow Transplant 15(1):54–60

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Biron CA, Welsh RM (1982) Blastogenesis of natural killer cells during viral infection in vivo. J Immunol 129(6):2788–2795

    CAS  PubMed  Google Scholar 

  • Biron CA, Turgiss LR, Welsh RM (1983) Increase in NK cell number and turnover rate during acute viral infection. J Immunol 131(3):1539–1545

    CAS  PubMed  Google Scholar 

  • Biron CA, Byron KS, Sullivan JL (1989) Severe herpesvirus infections in an adolescent without natural killer cells. N Engl J Med 320(26):1731–1735

    Article  CAS  PubMed  Google Scholar 

  • Bishara A, De Santis D, Witt CC et al (2004) The beneficial role of inhibitory KIR genes of HLA class I NK epitopes in haploidentically mismatched stem cell allografts may be masked by residual donor-alloreactive T cells causing GVHD. Tissue Antigens 63(3):204–211

    Article  CAS  PubMed  Google Scholar 

  • Bordignon C, Daley JP, Nakamura I (1985) Hematopoietic histoincompatibility reactions by NK cells in vitro: model for genetic resistance to marrow grafts. Science 230(4732):1398–1401

    Article  CAS  PubMed  Google Scholar 

  • Bowden RA, Day LM, Amos DE, Meyers JD (1987) Natural cytotoxic activity against cytomegalovirus-infected target cells following marrow transplantation. Transplantation 44(4):504–508

    Article  CAS  PubMed  Google Scholar 

  • Braud VM, Allan DS, O’Callaghan CA et al (1998) HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C. Nature 391(6669):795–799

    Article  CAS  PubMed  Google Scholar 

  • Brown MG, Dokun AO, Heusel JW et al (2001) Vital involvement of a natural killer cell activation receptor in resistance to viral infection. Science 292(5518):934–937

    Article  CAS  PubMed  Google Scholar 

  • Brunstein CG, Wagner JE, Weisdorf DJ et al (2009) Negative effect of KIR alloreactivity in recipients of umbilical cord blood transplant depends on transplantation conditioning intensity. Blood 113(22):5628–5634

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Bukowski JF, Warner JF, Dennert G, Welsh RM (1985) Adoptive transfer studies demonstrating the antiviral effect of natural killer cells in vivo. J Exp Med 161(1):40–52

    Article  CAS  PubMed  Google Scholar 

  • Cannon MJ, Schmid DS, Hyde TB (2010) Review of cytomegalovirus seroprevalence and demographic characteristics associated with infection. Rev Med Virol 20(4):202–213

    Article  PubMed  Google Scholar 

  • Carson WE, Giri JG, Lindemann MJ et al (1994) Interleukin (IL) 15 is a novel cytokine that activates human natural killer cells via components of the IL-2 receptor. J Exp Med 180(4):1395–1403

    Article  CAS  PubMed  Google Scholar 

  • Chan SH, Perussia B, Gupta JW et al (1991) Induction of interferon gamma production by natural killer cell stimulatory factor: characterization of the responder cells and synergy with other inducers. J Exp Med 173(4):869–879

    Article  CAS  PubMed  Google Scholar 

  • Colonna M, Samaridis J (1995) Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells. Science 268(5209):405–408

    Article  CAS  PubMed  Google Scholar 

  • Cooley S, Trachtenberg E, Bergemann TL et al (2009) Donors with group B KIR haplotypes improve relapse-free survival after unrelated hematopoietic cell transplantation for acute myelogenous leukemia. Blood 113(3):726–732

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Cooley S, Weisdorf DJ, Guethlein LA et al (2014) Donor killer cell Ig-like receptor B haplotypes, recipient HLA-C1, and HLA-C mismatch enhance the clinical benefit of unrelated transplantation for acute myelogenous leukemia. J Immunol 192(10):4592–4600

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Costa-Garcia M, Vera A, Moraru M, Vilches C, Lopez-Botet M, Muntasell A (2015) Antibody-Mediated Response of NKG2Cbright NK Cells against Human Cytomegalovirus. J Immunol 194(6):2715–2724

    Article  CAS  PubMed  Google Scholar 

  • Daley JP, Nakamura I (1984) Natural resistance of lethally irradiated F1 hybrid mice to parental marrow grafts is a function of H-2/Hh-restricted effectors. J Exp Med 159(4):1132–1148

    Article  CAS  PubMed  Google Scholar 

  • D’Andrea A, Chang C, Franz-Bacon K, McClanahan T, Phillips JH, Lanier LL (1995) Molecular cloning of NKB1. A natural killer cell receptor for HLA-B allotypes. J Immunol 155(5):2306–2310

    PubMed  Google Scholar 

  • De Baetselier P, Katzav S, Gorelik E, Feldman M, Segal S (1980) Differential expression of H-2 gene products in tumour cells in associated with their metastatogenic properties. Nature 288(5787):179–181

    Article  PubMed  Google Scholar 

  • Deeg HJ, Storb R, Thomas ED et al (1985) Cyclosporine as prophylaxis for graft-versus-host disease: a randomized study in patients undergoing marrow transplantation for acute nonlymphoblastic leukemia. Blood 65(6):1325–1334

    CAS  PubMed  Google Scholar 

  • Dinsmore R, Kirkpatrick D, Flomenberg N et al (1984) Allogeneic bone marrow transplantation for patients with acute nonlymphocytic leukemia. Blood 63(3):649–656

    CAS  PubMed  Google Scholar 

  • Doherty PC, Knowles BB, Wettstein PJ (1984) Immunological surveillance of tumors in the context of major histocompatibility complex restriction of T cell function. Adv Cancer Res 42:1–65

    Article  CAS  PubMed  Google Scholar 

  • Dohring C, Scheidegger D, Samaridis J, Cella M, Colonna M (1996) A human killer inhibitory receptor specific for HLA-A1,2. J Immunol 156(9):3098–3101

    CAS  PubMed  Google Scholar 

  • Dupont E, Huygen K, Schandene L, Vandercruys M, Palfliet K, Wybran J (1984) Depressed natural killer function in transplant recipients: an analysis. Transplant Proc 16(6):1506–1508

    CAS  PubMed  Google Scholar 

  • Eisenbach L, Segal S, Feldman M (1983) MHC imbalance and metastatic spread in Lewis lung carcinoma clones. Int J Cancer 32(1):113–120

    Article  CAS  PubMed  Google Scholar 

  • Elmaagacli AH, Steckel NK, Koldehoff M et al (2011) Early human cytomegalovirus replication after transplantation is associated with a decreased relapse risk: evidence for a putative virus-versus-leukemia effect in acute myeloid leukemia patients. Blood 118(5):1402–1412

    Article  CAS  PubMed  Google Scholar 

  • Ettinghausen SE, Puri RK, Rosenberg SA (1988) Increased vascular permeability in organs mediated by the systemic administration of lymphokine-activated killer cells and recombinant interleukin-2 in mice. J Natl Cancer Inst 80(3):177–188

    Article  CAS  PubMed  Google Scholar 

  • Field AK, Davies ME, DeWitt C et al (1983) 9-([2-hydroxy-1-(hydroxymethyl)ethoxy]methyl)guanine: a selective inhibitor of herpes group virus replication. Proc Natl Acad Sci U S A 80(13):4139–4143

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Fischer JC, Ottinger H, Ferencik S et al (2007) Relevance of C1 and C2 epitopes for hemopoietic stem cell transplantation: role for sequential acquisition of HLA-C-specific inhibitory killer Ig-like receptor. J Immunol 178(6):3918–3923

    Article  CAS  PubMed  Google Scholar 

  • Foley B, Cooley S, Verneris MR et al (2012a) Cytomegalovirus reactivation after allogeneic transplantation promotes a lasting increase in educated NKG2C+ natural killer cells with potent function. Blood 119(11):2665–2674

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Foley B, Cooley S, Verneris MR et al (2012b) Human cytomegalovirus (CMV)-induced memory-like NKG2C(+) NK cells are transplantable and expand in vivo in response to recipient CMV antigen. J Immunol 189(10):5082–5088

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Ford CE, Hamerton JL, Barnes DW, Loutit JF (1956) Cytological identification of radiation-chimaeras. Nature 177(4506):452–454

    Article  CAS  PubMed  Google Scholar 

  • Gasteiger G, Hemmers S, Firth MA et al (2013) IL-2-dependent tuning of NK cell sensitivity for target cells is controlled by regulatory T cells. J Exp Med 210(6):1167–1178

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Geller MA, Cooley S, Judson PL et al (2011) A phase II study of allogeneic natural killer cell therapy to treat patients with recurrent ovarian and breast cancer. Cytotherapy 13(1):98–107

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Ghiringhelli F, Menard C, Terme M et al (2005) CD4+ CD25+ regulatory T cells inhibit natural killer cell functions in a transforming growth factor-beta-dependent manner. J Exp Med 202(8):1075–1085

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Grabstein KH, Eisenman J, Shanebeck K et al (1994) Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor. Science 264(5161):965–968

    Article  CAS  PubMed  Google Scholar 

  • Green ML, Leisenring WM, Xie H et al (2013) CMV reactivation after allogeneic HCT and relapse risk: evidence for early protection in acute myeloid leukemia. Blood 122(7):1316–1324

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Grimm EA, Mazumder A, Zhang HZ, Rosenberg SA (1982) Lymphokine-activated killer cell phenomenon. Lysis of natural killer-resistant fresh solid tumor cells by interleukin 2-activated autologous human peripheral blood lymphocytes. J Exp Med 155(6):1823–1841

    Article  CAS  PubMed  Google Scholar 

  • Guma M, Angulo A, Vilches C, Gomez-Lozano N, Malats N, Lopez-Botet M (2004) Imprint of human cytomegalovirus infection on the NK cell receptor repertoire. Blood 104(12):3664–3671

    Article  CAS  PubMed  Google Scholar 

  • Guma M, Budt M, Saez A et al (2006) Expansion of CD94/NKG2C+ NK cells in response to human cytomegalovirus-infected fibroblasts. Blood 107(9):3624–3631

    Article  CAS  PubMed  Google Scholar 

  • Hercend T, Takvorian T, Nowill A et al (1986) Characterization of natural killer cells with antileukemia activity following allogeneic bone marrow transplantation. Blood 67(3):722–728

    CAS  PubMed  Google Scholar 

  • Hoffman M, Mittelman A, Dworkin B et al (1989) Severe intrahepatic cholestasis in patients treated with recombinant interleukin-2 and lymphokine-activated killer cells. J Cancer Res Clin Oncol 115(2):175–178

    Article  CAS  PubMed  Google Scholar 

  • Hokland M, Jacobsen N, Ellegaard J, Hokland P (1988) Natural killer function following allogeneic bone marrow transplantation. Very early reemergence but strong dependence of cytomegalovirus infection. Transplantation 45(6):1080–1084

    Article  CAS  PubMed  Google Scholar 

  • Ito S, Pophali P, Co W et al (2013) CMV reactivation is associated with a lower incidence of relapse after allo-SCT for CML. Bone Marrow Transplant 48(10):1313–1316

    Article  CAS  PubMed  Google Scholar 

  • Jacobson LO (1952) Evidence for a humoral factor (or factors) concerned in recovery from radiation injury: a review. Cancer Res 12(5):315–325

    CAS  PubMed  Google Scholar 

  • Jacobson LO, Simmons EL, Marks EK, Robson MJ, Bethard WF, Gaston EO (1950) The role of the spleen in radiation injury and recovery. J Lab Clin Med 35(5):746–770

    CAS  PubMed  Google Scholar 

  • Johnson FL, Thomas ED, Clark BS, Chard RL, Hartmann JR, Storb R (1981) A comparison of marrow transplantation with chemotherapy for children with acute lymphoblastic leukemia in second or subsequent remission. N Engl J Med 305(15):846–851

    Article  CAS  PubMed  Google Scholar 

  • Jonjic S, Mutter W, Weiland F, Reddehase MJ, Koszinowski UH (1989) Site-restricted persistent cytomegalovirus infection after selective long-term depletion of CD4+ T lymphocytes. J Exp Med 169(4):1199–1212

    Article  CAS  PubMed  Google Scholar 

  • Karre K, Ljunggren HG, Piontek G, Kiessling R (1986) Selective rejection of H-2-deficient lymphoma variants suggests alternative immune defence strategy. Nature 319(6055):675–678

    Article  CAS  PubMed  Google Scholar 

  • Katzav S, De Baetselier P, Tartakovsky B, Feldman M, Segal S (1983) Alterations in major histocompatibility complex phenotypes of mouse cloned T10 sarcoma cells: association with shifts from nonmetastatic to metastatic cells. J Natl Cancer Inst 71(2):317–324

    CAS  PubMed  Google Scholar 

  • Khakoo SI, Thio CL, Martin MP et al (2004) HLA and NK cell inhibitory receptor genes in resolving hepatitis C virus infection. Science 305(5685):872–874

    Article  CAS  PubMed  Google Scholar 

  • Kiessling R, Hochman PS, Haller O, Shearer GM, Wigzell H, Cudkowicz G (1977) Evidence for a similar or common mechanism for natural killer cell activity and resistance to hemopoietic grafts. Eur J Immunol 7(9):655–663

    Article  CAS  PubMed  Google Scholar 

  • Kollman C, Howe CW, Anasetti C et al (2001) Donor characteristics as risk factors in recipients after transplantation of bone marrow from unrelated donors: the effect of donor age. Blood 98(7):2043–2051

    Article  CAS  PubMed  Google Scholar 

  • Lanier LL, Corliss BC, Wu J, Leong C, Phillips JH (1998) Immunoreceptor DAP12 bearing a tyrosine-based activation motif is involved in activating NK cells. Nature 391(6668):703–707

    Article  CAS  PubMed  Google Scholar 

  • Lee J, Zhang T, Hwang I et al (2015) Epigenetic Modification and Antibody-Dependent Expansion of Memory-like NK Cells in Human Cytomegalovirus-Infected Individuals. Immunity 42(3):431–442

    Article  CAS  PubMed  Google Scholar 

  • Lindsley DL, Odell TT Jr, Tausche FG (1955) Implantation of functional erythropoietic elements following total-body irradiation. Proc Soc Exp Biol Med 90(2):512–515

    Article  CAS  PubMed  Google Scholar 

  • Litwin V, Gumperz J, Parham P, Phillips JH, Lanier LL (1994) NKB1: a natural killer cell receptor involved in the recognition of polymorphic HLA-B molecules. J Exp Med 180(2):537–543

    Article  CAS  PubMed  Google Scholar 

  • Ljunggren HG, Karre K (1985) Host resistance directed selectively against H-2-deficient lymphoma variants. Analysis of the mechanism. J Exp Med 162(6):1745–1759

    Article  CAS  PubMed  Google Scholar 

  • Ljungman P (1998) Immune reconstitution and viral infections after stem cell transplantation. Bone Marrow Transplant 21(Suppl 2):S72–S74

    PubMed  Google Scholar 

  • Ljungman P, Brand R, Einsele H, Frassoni F, Niederwieser D, Cordonnier C (2003) Donor CMV serologic status and outcome of CMV-seropositive recipients after unrelated donor stem cell transplantation: an EBMT megafile analysis. Blood 102(13):4255–4260

    Article  CAS  PubMed  Google Scholar 

  • Lo Monaco E, Tremante E, Cerboni C, et al (2011) Human leukocyte antigen E contributes to protect tumor cells from lysis by natural killer cells. Neoplasia 13(9):822–830

    Google Scholar 

  • Lonnqvist B, Ringden O, Ljungman P, Wahren B, Gahrton G (1986) Reduced risk of recurrent leukaemia in bone marrow transplant recipients after cytomegalovirus infection. Br J Haematol 63(4):671–679

    Article  CAS  PubMed  Google Scholar 

  • Lorenz E, Uphoff D, Reid TR, Shelton E (1951) Modification of irradiation injury in mice and guinea pigs by bone marrow injections. J Natl Cancer Inst 12(1):197–201

    CAS  PubMed  Google Scholar 

  • Lotze MT, Grimm EA, Mazumder A, Strausser JL, Rosenberg SA (1981) Lysis of fresh and cultured autologous tumor by human lymphocytes cultured in T-cell growth factor. Cancer Res 41(11 Pt 1):4420–4425

    CAS  PubMed  Google Scholar 

  • Lowe EJ, Turner V, Handgretinger R et al (2003) T-cell alloreactivity dominates natural killer cell alloreactivity in minimally T-cell-depleted HLA-non-identical paediatric bone marrow transplantation. Br J Haematol 123(2):323–326

    Article  PubMed  Google Scholar 

  • Luetke-Eversloh M, Hammer Q, Durek P et al (2014) Human cytomegalovirus drives epigenetic imprinting of the IFNG locus in NKG2Chi natural killer cells. PLoS Pathog 10(10):e1004441

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  • Mancusi A, Ruggeri L, Urbani E et al (2015) Haploidentical hematopoietic transplantation from KIR ligand-mismatched donors with activating KIRs reduces non-relapse mortality. Blood 125(20):3173−3182

    Google Scholar 

  • Marin R, Ruiz-Cabello F, Pedrinaci S et al (2003) Analysis of HLA-E expression in human tumors. Immunogenetics 54(11):767–775

    CAS  PubMed  Google Scholar 

  • Martin MP, Gao X, Lee JH et al (2002) Epistatic interaction between KIR3DS1 and HLA-B delays the progression to AIDS. Nat Genet 31(4):429–434

    CAS  PubMed  Google Scholar 

  • Mathe G, Schwarzenberg L, Amiel JL et al (1967) Immunogenetic and immunological problems of allogeneic haemopoietic radio-chimaeras in man. Scand J Haematol 4(3):193–216

    Article  CAS  PubMed  Google Scholar 

  • Mathe G, Schwarzenberg L, Halle-Pannenko O, Abuaf N, Pouillart P (1977) Of mice and men in bone marrow transplantation. Transplant Proc 9(1):155–168

    CAS  PubMed  Google Scholar 

  • Miller JS, Soignier Y, Panoskaltsis-Mortari A et al (2005) Successful adoptive transfer and in vivo expansion of human haploidentical NK cells in patients with cancer. Blood 105(8):3051–3057

    Article  CAS  PubMed  Google Scholar 

  • Miller JS, Cooley S, Parham P et al (2007) Missing KIR ligands are associated with less relapse and increased graft-versus-host disease (GVHD) following unrelated donor allogeneic HCT. Blood 109(11):5058–5061

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Milone MC, Fish JD, Carpenito C et al (2009) Chimeric receptors containing CD137 signal transduction domains mediate enhanced survival of T cells and increased antileukemic efficacy in vivo. Mol Ther 17(8):1453–1464

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Moretta A, Vitale M, Bottino C et al (1993) P58 molecules as putative receptors for major histocompatibility complex (MHC) class I molecules in human natural killer (NK) cells. Anti-p58 antibodies reconstitute lysis of MHC class I-protected cells in NK clones displaying different specificities. J Exp Med 178(2):597–604

    Article  CAS  PubMed  Google Scholar 

  • Nachbaur D, Bonatti H, Oberaigner W et al (2001) Survival after bone marrow transplantation from cytomegalovirus seropositive sibling donors. Lancet 358(9288):1157–1159

    Article  CAS  PubMed  Google Scholar 

  • Neiman P, Wasserman PB, Wentworth BB et al (1973) Interstitial pneumonia and cytomegalovirus infection as complications of human marrow transplantation. Transplantation 15(5):478–485

    Article  CAS  PubMed  Google Scholar 

  • Nguyen S, Dhedin N, Vernant JP et al (2005) NK-cell reconstitution after haploidentical hematopoietic stem-cell transplantations: immaturity of NK cells and inhibitory effect of NKG2A override GvL effect. Blood 105(10):4135–4142

    Article  CAS  PubMed  Google Scholar 

  • Ni J, Miller M, Stojanovic A, Garbi N, Cerwenka A (2012) Sustained effector function of IL-12/15/18-preactivated NK cells against established tumors. J Exp Med 209(13):2351–2365

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Nowell PC, Cole LJ, Habermeyer JG, Roan PL (1956) Growth and continued function of rat marrow cells in x-radiated mice. Cancer Res 16(3):258–261

    CAS  PubMed  Google Scholar 

  • Oevermann L, Michaelis SU, Mezger M et al (2014) KIR B haplotype donors confer a reduced risk for relapse after haploidentical transplantation in children with ALL. Blood 124(17):2744–2747

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Okamura H, Tsutsi H, Komatsu T et al (1995) Cloning of a new cytokine that induces IFN-gamma production by T cells. Nature 378(6552):88–91

    Article  CAS  PubMed  Google Scholar 

  • Olcese L, Lang P, Vely F et al (1996) Human and mouse killer-cell inhibitory receptors recruit PTP1C and PTP1D protein tyrosine phosphatases. J Immunol 156(12):4531–4534

    CAS  PubMed  Google Scholar 

  • Poole E, McGregor Dallas SR, Colston J, Joseph RS, Sinclair J (2011) Virally induced changes in cellular microRNAs maintain latency of human cytomegalovirus in CD34(+) progenitors. J Gen Virol 92(Pt 7):1539–1549

    Google Scholar 

  • Quinnan GV Jr, Kirmani N, Rook AH et al (1982) Cytotoxic t cells in cytomegalovirus infection: HLA-restricted T-lymphocyte and non-T-lymphocyte cytotoxic responses correlate with recovery from cytomegalovirus infection in bone-marrow-transplant recipients. N Engl J Med 307(1):7–13

    Article  PubMed  Google Scholar 

  • Reddehase MJ, Mutter W, Munch K, Buhring HJ, Koszinowski UH (1987) CD8-positive T lymphocytes specific for murine cytomegalovirus immediate-early antigens mediate protective immunity. J Virol 61(10):3102–3108

    PubMed Central  CAS  PubMed  Google Scholar 

  • Remberger M, Ringden O (2002) Survival after bone-marrow transplantation. Lancet 359(9309):888

    Article  PubMed  Google Scholar 

  • Rosenberg SA, Mule JJ, Spiess PJ, Reichert CM, Schwarz SL (1985) Regression of established pulmonary metastases and subcutaneous tumor mediated by the systemic administration of high-dose recombinant interleukin 2. J Exp Med 161(5):1169–1188

    Article  CAS  PubMed  Google Scholar 

  • Rosenberg SA, Lotze MT, Muul LM et al (1987) A progress report on the treatment of 157 patients with advanced cancer using lymphokine-activated killer cells and interleukin-2 or high-dose interleukin-2 alone. N Engl J Med 316(15):889–897

    Article  CAS  PubMed  Google Scholar 

  • Ruggeri L, Capanni M, Casucci M et al (1999) Role of natural killer cell alloreactivity in HLA-mismatched hematopoietic stem cell transplantation. Blood 94(1):333–339

    CAS  PubMed  Google Scholar 

  • Ruggeri L, Capanni M, Urbani E et al (2002) Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants. Science 295(5562):2097–2100

    Article  CAS  PubMed  Google Scholar 

  • Schlums H, Cichocki F, Tesi B et al (2015) Cytomegalovirus Infection Drives Adaptive Epigenetic Diversification of NK Cells with Altered Signaling and Effector Function. Immunity 42(3):443–456

    Article  CAS  PubMed  Google Scholar 

  • Selby P, Powles RL, Jameson B, Stolle K, Tryhorn Y, Stern H (1986) Treatment of cytomegalovirus pneumonitis after bone marrow transplantation with 9-[2-hydroxy-1-(hydroxymethyl) ethoxymethyl] guanine. Lancet 1(8494):1377–1378

    Article  CAS  PubMed  Google Scholar 

  • Sitrin J, Ring A, Garcia KC, Benoist C, Mathis D (2013) Regulatory T cells control NK cells in an insulitic lesion by depriving them of IL-2. J Exp Med 210(6):1153–1165

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Sun JC, Beilke JN, Lanier LL (2009) Adaptive immune features of natural killer cells. Nature 457(7229):557–561

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Suto Y, Maenaka K, Yabe T et al (1996) Chromosomal localization of the human natural killer cell class I receptor family genes to 19q13.4 by fluorescence in situ hybridization. Genomics 35(1):270–272

    Article  CAS  PubMed  Google Scholar 

  • Sylwester AW, Mitchell BL, Edgar JB et al (2005) Broadly targeted human cytomegalovirus-specific CD4+ and CD8+ T cells dominate the memory compartments of exposed subjects. J Exp Med 202(5):673–685

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Thomas ED, Lochte HL Jr, Lu WC, Ferrebee JW (1957) Intravenous infusion of bone marrow in patients receiving radiation and chemotherapy. N Engl J Med 257(11):491–496

    Article  CAS  PubMed  Google Scholar 

  • Thomson KJ, Mackinnon S, Peggs KS (2012) CMV-specific cellular therapy for acute myeloid leukemia? Blood 119(4):1088–1090; author reply 1090–1081

    Google Scholar 

  • Tomasec P, Braud VM, Rickards C et al (2000) Surface expression of HLA-E, an inhibitor of natural killer cells, enhanced by human cytomegalovirus gpUL40. Science 287(5455):1031

    Article  CAS  PubMed  Google Scholar 

  • Uhrberg M, Valiante NM, Shum BP et al (1997) Human diversity in killer cell inhibitory receptor genes. Immunity 7(6):753–763

    Article  CAS  PubMed  Google Scholar 

  • Ulbrecht M, Martinozzi S, Grzeschik M et al (2000) Cutting edge: the human cytomegalovirus UL40 gene product contains a ligand for HLA-E and prevents NK cell-mediated lysis. J Immunol 164(10):5019–5022

    Article  CAS  PubMed  Google Scholar 

  • Venstrom JM, Pittari G, Gooley TA et al (2012) HLA-C-dependent prevention of leukemia relapse by donor activating KIR2DS1. N Engl J Med 367(9):805–816

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Wagtmann N, Biassoni R, Cantoni C et al (1995) Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and intracellular domains. Immunity 2(5):439–449

    Article  CAS  PubMed  Google Scholar 

  • Weiden PL, Flournoy N, Thomas ED et al (1979) Antileukemic effect of graft-versus-host disease in human recipients of allogeneic-marrow grafts. N Engl J Med 300(19):1068–1073

    Article  CAS  PubMed  Google Scholar 

  • Weiden PL, Sullivan KM, Flournoy N, Storb R, Thomas ED (1981) Antileukemic effect of chronic graft-versus-host disease: contribution to improved survival after allogeneic marrow transplantation. N Engl J Med 304(25):1529–1533

    Article  CAS  PubMed  Google Scholar 

  • Welsh RM Jr (1978) Mouse natural killer cells: induction specificity, and function. J Immunol 121(5):1631–1635

    PubMed  Google Scholar 

  • Wuest TY, Willette-Brown J, Durum SK, Hurwitz AA (2008) The influence of IL-2 family cytokines on activation and function of naturally occurring regulatory T cells. J Leukoc Biol 84(4):973–980

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Yron I, Wood TA Jr, Spiess PJ, Rosenberg SA (1980) In vitro growth of murine T cells. V. The isolation and growth of lymphoid cells infiltrating syngeneic solid tumors. J Immunol 125(1):238–245

    CAS  PubMed  Google Scholar 

  • Zhang T, Scott JM, Hwang I, Kim S (2013) Cutting edge: antibody-dependent memory-like NK cells distinguished by FcRgamma deficiency. J Immunol 190(4):1402–1406

    Article  PubMed Central  CAS  PubMed  Google Scholar 

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Acknowledgments

This work was supported by P01 CA111412 (FC, MRV, SC, YTB, DJW, JSM), P01 CA65493 (FC, MRV SC, CGB, BRB, JW, JSM) and R01CA72669 (BRB).

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Authors and Affiliations

  1. Department of Medicine, University of Minnesota, Minneapolis, MN, USA

    Frank Cichocki, Sarah Cooley, Veronika Bachanova, Claudio G. Brunstein, Daniel J. Weisdorf & Jeffrey S. Miller

  2. Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA

    Michael R. Verneris, Bruce R. Blazar & John Wagner

  3. Centre for Infectious Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden

    Heinrich Schlums & Yenan T. Bryceson

  4. Broeglmann Research Laboratory, Clinical Institute, University of Bergen, Bergen, Norway

    Yenan T. Bryceson

  5. MMC 806, Division of Hematology, Oncology and Transplantation, University of Minnesota Cancer Center, Harvard Street at East River Road, Minneapolis, MN, 55455, USA

    Jeffrey S. Miller

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  1. Frank Cichocki
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  2. Michael R. Verneris
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  3. Sarah Cooley
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  4. Veronika Bachanova
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  5. Claudio G. Brunstein
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  6. Bruce R. Blazar
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  7. John Wagner
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  8. Heinrich Schlums
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  9. Yenan T. Bryceson
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  10. Daniel J. Weisdorf
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  11. Jeffrey S. Miller
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Correspondence to Jeffrey S. Miller .

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  1. Assistance Publique des Hôpitaux de Marseille, Marseille 05, France and Centre d'Immunologie de Marseille-Luminy, Aix Marseille Université - INSERM - CNRS, Marseille 09, France

    Eric Vivier

  2. INSERM U 668, Pasteur Institute, Paris, Paris, France

    James Di Santo

  3. University of Genoa, Genova, Italy

    Alessandro Moretta

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Cichocki, F. et al. (2015). The Past, Present, and Future of NK Cells in Hematopoietic Cell Transplantation and Adoptive Transfer. In: Vivier, E., Di Santo, J., Moretta, A. (eds) Natural Killer Cells. Current Topics in Microbiology and Immunology, vol 395. Springer, Cham. https://doi.org/10.1007/82_2015_445

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