Photorhabdus luminescens Toxins TccC3 and TccC5: Insecticidal ADP-Ribosyltransferases that Modify Threonine and Glutamine

  • Klaus Aktories
  • Gudula Schmidt
  • Alexander E. Lang
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 384)


The ADP-ribosyltransferases TccC3 and TccC5 are the biologically active TcC components of the tripartite Photorhabdus luminescens Tc toxin, which consist of TcA, TcB, and TcC components. TcA is the binding and membrane translocation component. TcB is a functional linker between TcC and TcA and also involved in the translocation of the toxin. While TccC3 ADP-ribosylates actin at threonine 148, TccC5 modifies Rho proteins at glutamine 61/63. Both modifications result in major alteration of the actin cytoskeleton. Here we discuss structure and function of the Tc toxin and compare its ADP-ribosyltransferase activities with other types of actin and Rho modifying toxins.


Actin Cytoskeleton Diphtheria Toxin Yersinia Enterocolitica Stress Fiber Formation Filopodium Formation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



This work was supported by the German Research Foundation (DFG) and the Center for Biological Signaling Studies (BIOSS) in Freiburg (Germany).


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Copyright information

© Springer International Publishing Switzerland 2014

Authors and Affiliations

  • Klaus Aktories
    • 1
  • Gudula Schmidt
    • 1
  • Alexander E. Lang
    • 1
  1. 1.Institut für Experimentelle und Klinische Pharmakologie und Toxikologie, Albert-Ludwigs-Universität FreiburgFreiburgGermany

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