Abstract
Cholera is a global health problem as several thousands of cases and deaths occur each year. The unique epidemiologic attribute of the disease is its propensity to occur as outbreaks that may flare-up into epidemics, if not controlled. The causative bacterial pathogen Vibrio cholerae prevails in the environment and infects humans whenever there is a breakdown in the public health component. The Indian subcontinent is vulnerable to this disease due its vast coastlines with areas of poor sanitation, unsafe drinking water, and overcrowding. Recently, it was shown that climatic conditions also play a major role in the persistence and spread of cholera. Constant change in the biotypes and serotypes of V. cholerae are also important aspects that changes virulence and survival of the pathogen. Such continuous changes increase the infection ability of the pathogen affecting the susceptible population including the children. The short-term carrier status of V. cholerae has been studied well at community level and this facet significantly contributes to the recurrence of cholera. Several molecular tools recognized altering clonality of V. cholerae in relation with the advent of a serogroup or serotype. Rapid identification systems were formulated for the timely detection of the pathogen so as to identify and control the outbreak and institute proper treatment of the patients. The antimicrobials used in the past are no longer useful in the treatment of cholera as V. cholerae has acquired several mechanisms for multiple antimicrobial resistance. This upsurge in antimicrobial resistance directly influences the management of the disease. This chapter provides an overview of cholera prevalence in India, possible sources of infection, and molecular epidemiology along with antimicrobial resistance of V. cholerae.
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Aggarwal P, Khanna KK, Kumari S (1989) Cholera gastroenteritis amongst children in Delhi. Indian J Pediatr 56:93–96
Agarwal V, Biswas M, Chande CA, Pathak AA, Saoji AM (1994) Changing bacteriological profile of cholera in Nagpur, 1991–93. Indian J Med Res 100:93–94
Agrawal G, Jalgaonkar SV, Jagtap PM, Kamlakar UP, Deogade NG (2003) Emergence and re-emergence of Vibrio cholerae O139: an epidemiological study during 1993–2002 at Nagpur, Central India. Indian J Med Sci 57:155–157
Ambhore NA, Ingole KV, Fule RP (2000) Reappearance of Vibrio cholerae serogroup O139 in Yavatmal during June-August-1998. Indian J Med Sci 54:63–64
Amin V, Patwari AK, Kumar G, Anand VK, Diwan N, Peshin S (1995) Clinical profile of cholera in young children-a hospital based report. Indian Pediatr 32:755–761
Amita, Chowdhury SR, Thungapathra M, Ramamurthy T, Nair GB, Ghosh A (2003) Class I integrons and SXT elements in El Tor strains isolated before and after 1992 Vibrio cholerae O139 outbreak, Calcutta, India. Emerg Infect Dis 9:500–502
Bag PK, Maiti S, Sharma C et al (1998) Rapid spread of the new clone of Vibrio cholerae O1 biotype El Tor in cholera endemic areas in India. Epidemiol Infect 21:245–251
Bajaj JK, Baradker VP, Joshi SG, Damle AS, Kayararte RP, Deshmukh AB (2001) Epidemiology of cholera-a five-year study. J Commun Dis 33:282–285
Balaji K, Okonjo PA, Thenmozhi R, Karutha Pandian S (2013) Virulence and multidrug resistance patterns of Vibrio cholerae O1 isolates from diarrheal outbreaks of South India during 2006–2009. Microb Drug Resist 19:198–203
Ballal M, Nandanan B, Shivananda PG (2001) Emergence of Vibrio cholerae O139 in Manipal-coastal Karnataka-South India. Indian J Pathol Microbiol 44:177
Baranwal S, Dey K, Ramamurthy T, Nair GB, Kundu M (2002) Role of active efflux in association with target gene mutations in fluoroquinolone resistance in clinical isolates of Vibrio cholerae. Antimicrob Agents Chemother 46:2676–2678
Barua D (1992) History of cholerae. In: Barua D, Greenough WB III (eds) Cholera. Plenum Publishing, New York, pp 1–55
Basu A, Mukhopadhyay AK, Sharma C et al (1998) Heterogeneity in the organization of the CTX genetic element in strains of Vibrio cholerae O139 Bengal isolated from Calcutta, India and Dhaka, Bangladesh and its possible link to the dissimilar incidence of O139 cholera in the two locales. Microb Pathog 24:1751–1783
Basu A, Garg P, Datta S et al (2000a) Vibrio cholerae O139 in Calcutta, 1992–1998: incidence, antibiograms, and genotypes. Emerg Infect Dis 6:139–147
Basu A, Mukhopadhyay AK, Garg P et al (2000b) Diversity in the arrangement of the CTX prophages in classical strains of Vibrio cholerae O1. FEMS Microbiol Lett 182:35–40
Batabyal P, Mookerjee S, Palit A (2012) Occurrence of toxigenic Vibrio cholerae in accessible water sources of cholera endemic foci in India. Jpn J Infect Dis 65:358–360
Bhadra RK, Roychoudhury S, Banerjee RK et al (1995) Cholera toxin (CTX) genetic element in Vibrio cholerae O139. Microbiol 141:1977–1983
Bhanumathi R, Sabeena F, Isac SR, Radhakutty G, Singh DV (2002) Characterization of a toxigenic Vibrio cholerae O139 strain belonging to a new ribotype and isolated from a diarrheal patient. J Clin Microbiol 40:4779–4781
Bhanumathi R, Sabeena F, Isac SR, Shukla BN, Singh DV (2003) Molecular characterization of Vibrio cholerae O139 Bengal isolated from water and the aquatic plant Eichhornia crassipes in the River Ganga, Varanasi, India. Appl Environ Microbiol 69:2389–2394
Bhardwaj AK, Thakur TS, Sharma VK, Ahluwalia SK, Vaidya NK (1993) Problems and prospects of a traditional source of potable water in hilly terrains. Indian J Public Health 37:111–113
Bhattacharya SK, Bhattacharya MK, Dutta P (1990) Double-blind, randomized, controlled clinical trial of norfloxacin for cholera. Antimicrob Agents Chemother 34:939–940
Bhattacharya SK, Datta D, Bhattacharya MK et al (1992) Cholera in young children in an endemic area. Lancet 340:1549
Bhattacharya SK, Bhattacharya MK, Nair GB et al (1993) Clinical profile of acute diarrhoea cases infected with the new epidemic strain of Vibrio cholerae O139: designation of the disease as cholera. J Infect 27:11–15
Bhattacharya SK, Goswami AG, Bhattacharya MK et al (1994) Epidemic of Vibrio cholerae O139 in Calcutta. Indian J Med Res 100:213–216
Bhattacharya MK, Ghosh S, Mukhopadhyay AK, Deb A, Bhattacharya SK (2000) Outbreak of cholera caused by Vibrio cholerae O1 intermediately resistant to norfloxacin at Malda, West Bengal. J Indian Med Assoc 98:389–390
Bhattacharya MK, Dutta D, Ramamurthy T, Sarkar D, Singharoy A, Bhattacharya SK (2003) Azithromycin in the treatment of cholera in children. Acta Paediatr 92:676–678
Bhunia R, Ramakrishnan R, Hutin Y, Gupte MD (2009) Cholera outbreak secondary to contaminated pipe water in an urban area, West Bengal, India, 2006. Indian J Gastroenterol 28:62–64
Bora D, Dhariwal AC, Jain DC et al (1997) V. cholerae O1 outbreak in remote villages of Shimla district, Himachal Pradesh, 1994. J Commun Dis 29:121–125
Borkakoty B, Biswas D, Devi U, Yadav K, Mahanta J (2012) Emergence of classical ctxB genotype 1 and tetracycline resistant strains of Vibrio cholerae O1 El Tor in Assam, India. Trans R Soc Trop Med Hyg 106:382–386
Carpenter CC, Sack RB, Mondal A, Mitra PP (1964) Tetracycline therapy in cholera. J Indian Med Assoc 43:309–312
Ceccarelli D, Spagnoletti M, Bacciu D et al (2011) ICEVchInd5 is prevalent in epidemic Vibrio cholerae O1 El Tor strains isolated in India. Int J Med Microbiol 301:318–324
Chakrabarti MK, Bhattacharya MK, Sinha AK, Chatterjee DC, Bhattacharya SK (1993) Evaluation of the efficacy of different antibiotics in inhibiting colonisation of Vibrio cholerae O1 in the rabbit intestine. Zentralbl Bakteriol 278:69–72
Chakraborty S, Deokule JS, Garg P et al (2001) Concomitant infection of enterotoxigenic Escherichia coli in an outbreak of cholera caused by Vibrio cholerae O1 and O139 in Ahmedabad, India. J Clin Microbiol 39:3241–3246
Chander J, Kaistha N, Gupta V et al (2009) Epidemiology and antibiograms of Vibrio cholerae isolates from a tertiary care hospital in Chandigarh, North India. Indian J Med Res 129:613–617
Chatterjee S, Ghosh K, Raychoudhuri A et al (2007) Phenotypic and genotypic traits and epidemiological implication of Vibrio cholerae O1 and O139 strains in India during 2003. J Med Microbiol 56:824–832
Chhotray GP, Pal BB, Khuntia HK et al (2002) Incidence and molecular analysis of Vibrio cholerae associated with cholera outbreak subsequent to the super cyclone in Orissa, India. Epidemiol Infect 128:131–138
Cholera Research Center (1970) Annual Report
Cholera Research Center (1971) Annual Report
Cholera Research Center (1972) Annual Report
Cholera Research Center (1973) Annual Report
Cholera Research Center (1974) Annual Report
Cholera Research Center (1976) Annual Report
Cholera Research Center (1977) Annual Report
Cholera Research Center (1978) Annual Report
Cholera Research Center (1979) Annual Report
Constantin de Magny G, Murtugudde R, Sapiano MRP et al (2008) Environmental signatures associated with cholera epidemics. Proc Natl Acad Sci U S A 105:17676–17681
Darbari BS, Tiwari HL, Agarwal S et al (1982) Pattern of cholera in Raipur: a twelve year appraisal. J Indian Assoc Commun Dis 5:83–87
Das S, Gupta S (2005) Diversity of Vibrio cholerae strains isolated in Delhi, India, during 1992–2000. J Health Popul Nutr 23:44–51
Das A, Manickam P, Hutin Y et al (2009a) Two sequential outbreaks in two villages illustrate the various modes of transmission of cholera. Epidemiol Infect 137:906–912
Das A, Manickam P, Hutin Y et al (2009b) An outbreak of cholera associated with an unprotected well in Parbatia, Orissa, Eastern India. J Health Popul Nutr 27:646–651
Dastidar SG, Narayanaswami A (1968) The occurrence of chitinase in vibrios. Indian J Med Res 56:654–658
Datta KK, Bandyopadhyay S, Khanna KK, Banerjee K (1993) Epidemiological features of cholera outbreak in Delhi in 1988. J Commun Dis 25:57–61
De SN, Bhattacharya KK, Mondal A (1957) J Indian Med Assoc xxvii:514
De SN (1961) Cholera Its Pathology and Pathogenesis. Oliver and Boyd, London
De S, Sircar BK, Sasmal D, De SP, Mondal A (1974) Ibuprofen (Brufen) in cholera and other diarrhoeas. Indian J Med Res 62:756
Deb BC, Sengupta PG, De SP, Sil J, Sikdar SN, Pal SC (1976) Effect of sulfadoxine on transmission of Vibrio cholerae infection among family contacts of cholera patients in Calcutta. Bull World Health Organ 54:171–176
Deb BC, Sircar BK, Sengupta PG et al (1986) Studies on the interventions to prevent El Tor cholera transmission in urban slums. Bull Wld Hlth Org 64:127–131
Dhamodaran S, Ananthan S, Kuganantham P (1995) A retrospective analysis of the Madras epidemic of non-O1 Vibrio cholerae new serogroup O139 Bengal. Indian J Med Res 101:94–97
Dutta JK, Santhanam S, Misra BS, Ray SN (1978) Effect of trimethoprim-sulphamethoxazole on vibrio clearance in cholera (El Tor): a comparative study. Trans R Soc Trop Med Hyg 72:40–42
Dutta D, Bhattacharya SK, Bhattacharya MK et al (1996) Efficacy of norfloxacin and doxycycline for treatment of Vibrio cholerae O139 infection. J Antimicrob Chemother 37:575–581
Fazil MH, Bhanumathi R, Pandey HP, Singh DV (2011) Characterization of Vibrio cholerae O139 belonging to multiple ribotypes and isolated from diarrhoeal patients in Kerala, Southern India. Infect Genet Evol 11:454–459
Fotedar R (2001) Vector potential of houseflies (Musca domestica) in the transmission of Vibrio cholerae in India. Acta Trop 78:31–44
Fule RP, Powar RM, Menon S, Basutkar SH, Saoji AM (1990) Cholera epidemic in Solapur during July–August, 1988. Indian J Med Res 91:24–26
Fule RP, Jalgaonkar SV, Ingole KV, Fule C (1995) Outbreak due to Vibrio cholerae E1 Tor and serotype O139 in Yavatmal (Maharashtra) during June–July, 1994. Indian J Med Res 101:62–63
Ganguly R, Ghosh AK, Shrivastava DL (1966) Effect of chlorine on some of the biological characters of Vibrio cholerae. Indian J Med Res 54:24
Garg P, Nandy RK, Chaudhury P et al (2000a) Emergence of Vibrio cholerae O1 biotype El Tor serotype Inaba from the prevailing O1 Ogawa serotype strains in India. J Clin Microbiol 38:4249–4253
Garg P, Chakraborty S, Basu I et al (2000b) Expanding multiple antibiotic resistance among clinical strains of Vibrio cholerae isolated from 1992–1997 in Calcutta, India. Epidemiol Infect 124:393–399
Garg P, Sinha S, Chakraborty R et al (2001) Emergence of fluoroquinolone-resistant strains of Vibrio cholerae O1 biotype El Tor among hospitalized patients with cholera in Calcutta, India. Antimicrob Agents Chemother 45:1605–1606
Garg P, Aydanian A, Smith D, Glenn JM, Nair GB, Stine OC (2003) Molecular epidemiology of O139 Vibrio cholerae: mutation, lateral gene transfer, and founder flush. Emerg Infect Dis 9:810–814
Ghosh R, Nair GB, Tang L et al (2008) Epidemiological study of Vibrio cholerae using variable number of tandem repeats. FEMS Microbiol Lett 288:196–201
Godbole SH, Wagle PM (1970) Isolation of Vibrio cholerae from a well water during a small outbreak of cholera. Indian J Med Sci 24:484–486
Goel AK, Jiang SC (2010) Genetic determinants of virulence, antibiogram and altered biotype among the Vibrio cholerae O1 isolates from different cholera outbreaks in India. Infect Genet Evol 10:815–819
Goel AK, Jiang SC (2011) Association of heavy rainfall on genotypic diversity in V. cholerae isolates from an outbreak in India. Int J Microbiol 2011:230597
Gomber S, Mathur M, Sharma PP (1995) Diarrhoeal outbreak of Vibrio cholerae O139 from north India. Acta Paediatr 84:206–207
Guha-Mazumdar DN, Sircar BK, De SP (1974) Minocycline in the treatment of cholera: comparison with tetracycline. Indian J Med Res 62:712
Gupta DN, Sen D, Saha MR et al (1990) Report of an outbreak of diarrhoeal disease caused by cholera followed by rotavirus in Manipur. Indian J Public Health 34:62–65
Gupta A, Jain S, Mahawal BS (1999a) Outbreak of cholera in arid zone of Bikaner. Indian J Med Res 110:126–127
Gupta DN, Sarkar BL, Bhattacharya MK, Sengupta PG, Bhattacharya SK (1999b) An El Tor cholera outbreak in Maldah district, West Bengal. J Commun Dis 31:49–52
Gupta RS, Meena VR, Jain DC, Datta KK (2002) Cholera outbreak in rural areas of Southern Rajasthan. J Commun Dis 34:228–229
Gupta DN, Mondal SK, Sarkar BL, Mukherjee S, Bhattacharya SK (2004) An El tor cholera outbreak amongst tribal population in Tripura. J Commun Dis 36:271–276
Gupta N, Dewan S, Saini S (2005) Resurgence of Vibrio cholerae O139 in Rohtak. Indian J Med Res 121:128–130
Hamner S, Tripathi A, Mishra RK et al (2006) The role of water use patterns and sewage pollution in incidence of water-borne/enteric diseases along the Ganges river in Varanasi. India. Int J Environ Health Res 16:113–132
Hanumanthappa AR, Rajagopal V (2000) Serotypes and phage types of Vibrio cholerae in Mysore. J Commun Dis 32:313–315
Hasan JA, Huq A, Nair GB et al (1995) Development and testing of monoclonal antibody-based rapid immunodiagnostic test kits for direct detection of Vibrio cholerae O139 synonym Bengal. J Clin Microbiol 33:2935–2939
Hawgood BJ (2001) Sir Joseph Fayrer MD FRS (1824–1907) Indian Medical Service: snakebite and hospitalised patients with diarrhoea. J Med Microbiol 50:268–276
Howard-Jones N (1984) Robert Koch and the cholera vibrio: a centenary. Brt Med J 288:379–381
Ingole KV, Jalgaonkar SV, Fule C, Fule RP (1997) Changing pattern of Vibrio cholerae serotype El Tor and O139 in Yavatmal (Maharashtra, India) during 1992 to 1994. Indian J Pathol Microbiol 40:369–371
Jain RC, Bhat BD, Basutkar SH (1992) Tetracycline resistant El Tor Vibrios in Loni area. J Assoc Physicians India 40:636
Jain RC, Basutkar SH (1994) Endemicity of cholera among rural areas of Loni, Ahmednagar district of Maharashtra. Indian J Med Res 100:95–97
Jalgaonkar SV, Fule RP (1994) Cholera outbreak due to Vibrio cholerae serogroup O139 in Yavatmal (Maharashtra) in March–July, 1993. Indian J Med Res 99:101–102
Jesudason MV (2006) Change in serotype and appearance of tetracycline resistance in V. cholerae O1 in Vellore, South India. Indian J Med Microbiol 24:152–153
Jesudason MV, John TJ (1990) Transferable trimethoprim resistance of Vibrio cholerae O1 encountered in southern India. Trans R Soc Trop Med Hyg 84:136–137
Jesudason MV, Samuel R, John TJ (1994) Reappearance of Vibrio cholerae O1 and concurrent prevalence of O1 and O139 in Vellore, South India. Lancet 344:335–336
Jesudason MV, Saaya R (1997) Resistance of Vibrio cholerae O1 to nalidixic acid. Indian J Med Res 105:153–154
Jesudason MV, Balaji V, Thomson CJ (2002) Quinolone susceptibility of Vibrio cholerae O1 and O139 isolates from Vellore. Indian J Med Res 116:96–98
Joshi KR, Chaudhary SK, Singh R, Solanki A (1988) Cholera epidemic in Kharabera Purohitana, a village of west Rajasthan. Indian J Pathol Microbiol 31:178–181
Kamble TK, More SR, Chavan SS, Kulkarni ND, Lodha NS, Kamble AS (2000) Clinical profile of non-O1 strain-O139 of Vibrio cholerae in the region of Ambajogai, Maharashtra. J Assoc Physicians India 48:505–506
Kanungo S, Sah BK, Lopez AL et al (2010) Cholera in India: an analysis of reports, 1997–2006. Bull World Health Organ 88:185–191
Kaur H, Lal M (1998) Typing and antibiotic susceptibility patterns of Vibrio cholerae during six consecutive cholera seasons in north India. Trop Gastroenterol 19:59–61
Khanna KK, Dhanvijay A, Riley LW, Sehgal S, Kumari S (1990) Cholera outbreak in Delhi-1988. J Commun Dis 22:35–38
Khetawat G, Bhadra RK, Kar S, Das J (1998) Vibrio cholerae O139 Bengal: combined physical and genetic map and comparative analysis with the genome of V. cholerae O1. J Bacteriol 180:4516–4522
Khetawat G, Bhadra RK, Nandi S, Das J (1999) Resurgent Vibrio cholerae O139: rearrangement of cholera toxin genetic elements and amplification of rrn operon. Infect Immun 67:148–154
Khuntia HK, Pal BB, Meher PK, Chhotray GP (2008) Environmental Vibrio cholerae O139 may be the progenitor of outbreak of cholera in coastal area of Orissa, eastern India, 2000: molecular evidence. Am J Trop Med Hyg 78:819–822
Khuntia HK, Samal SK, Kar SK, Pal BB (2010) An Ogawa cholera outbreak 6 months after the Inaba cholera outbreaks in India, 2006. J Microbiol Immunol Infect 43:133–137
Kingston JJ, Zachariah K, Tuteja U, Kumar S, Batra HV (2009) Molecular characterization of Vibrio cholerae isolates from cholera outbreaks in North India. J Microbiol 47:110–115
Koch R (1884) Brit Med J ii:453
Krishna BV, Patil AB, Chandrasekhar MR (2006) Fluoroquinolone-resistant Vibrio cholerae isolated during a cholera outbreak in India. Trans R Soc Trop Med Hyg 100:224–226
Kumar P, Peter WA, Thomas S (2010) Rapid detection of virulence-associated genes in environmental strains of Vibrio cholerae by multiplex PCR. Curr Microbiol 60:199–202
Kumar P, Jain M, Goel AK, Kamboj DV, Kumar O (2012) Tetracycline resistant V. cholerae O1 biotype El Tor serotype Ogawa with classical ctxB from a recent cholera outbreak in Orissa, Eastern India. J Infect Public Health 5:217–219
Lutzkerand E, Jochnowitz C (1987) Waldemar Haffkine: Pioneer of Cholera vaccine. Am Soc Microbiol News 53:366–369
Macpherson J (1866) Cholera in its home. Churchill and Sons, London
Macpherson J (1872) Annals of cholera from the earliest periods to the year 1817. Ranken, London
MacNamara C (1876) A History of Asiatic Cholera. MacMillian, London
Mandal J, Sangeetha V, Ganesan V et al (2012) Third-generation cephalosporin-resistant Vibrio cholerae India. Emerg Infect Dis 18:1326–1328
Mehta MN, Daruwalla DR, Prabhu SV, Deodhar L (1986) An outbreak of cholera in children from Bombay slums. J Diarrhoeal Dis Res 4:94
Mishra M, Mohammed F, Akulwar SL, Katkar VJ, Tankhiwale NS, Powar RM (2004) Re-emergence of El Tor vibrio in outbreak of cholera in and around Nagpur. Indian J Med Res 120:478–480
Mishra A, Taneja N, Sharma RK, Kumar R, Sharma NC, Sharma M (2011) Amplified fragment length polymorphism of clinical and environmental Vibrio cholerae from a freshwater environment in a cholera-endemic area, India. BMC Infect Dis 11:249
Mitra R, Basu A, Dutta D, Nair GB, Takeda Y (1996) Resurgence of Vibrio cholerae O139 Bengal with altered antibiogram in Calcutta, India. Lancet 348:1181
Mohandas V, Unni J, Mathew M et al (1987) Aetiology and clinical features of acute childhood diarrhoea in an outpatient clinic in Vellore, India. Ann Trop Paediatr 7:167–172
Mohanty S, Kapil A, Das BK (2004) Seasonality and antimicrobial resistance pattern of Vibrio cholerae in a tertiary care hospital of North India. Trop Doct 34:249–251
Mohapatra SS, Ramachandran D, Mantri CK, Singh DV (2007) Characterization of the genetic background of Vibrio cholerae O1 biotype El Tor serotype Inaba strains isolated in Trivandrum, southern India. J Med Microbiol 56:260–265
Mukherjee S (1964) Cholera El Tor in Calcutta. Brit Med J 2:546–548
Mukherjee P, Ghosh S, Ramamurthy T et al (2010) Evaluation of a rapid immuno chromatographic dipstick kit for diagnosis of cholera emphasizes its outbreak utility. Jpn J Infect Dis 63:234–238
Mukherjee R, Halder D, Saha S et al (2011) Five pond-centred outbreaks of cholera in villages of West Bengal, India: evidence for focused interventions. J Health Popul Nutr 29:421–428
Mukhopadhyay AK, Garg S, Nair GB et al (1995) Biotype traits and antibiotic susceptibility of Vibrio cholerae serogroup O1 before, during and after the emergence of the O139 serogroup. Epidemiol Infect 115:427–434
Mukhopadhyay AK, Garg S, Mitra R et al (1996) Temporal shifts in traits of Vibrio cholerae strains isolated from hospitalized patients in Calcutta: a 3-year (1993 to 1995) analysis. J Clin Microbiol 34:2537–2543
Mukhopadhyay AK, Basu I, Bhattacharya SK, Bhattacharya MK, Nair GB (1998) Emergence of fluoroquinolone resistance in strains of Vibrio cholerae isolated from hospitalized patients with acute diarrhea in Calcutta, India. Antimicrob Agents Chemother 42:206–207
Murthy GV, Goswami A, Narayanan S, Amar S (1990) Effect of educational intervention on defaecation habits in an Indian urban slum. J Trop Med Hyg 93:189–193
Nair GB, Ramamurthy T, Bhattacharya SK et al (1994a) Spread of Vibrio cholerae O139 Bengal in India. J Infect Dis 169:1029–1034
Nair GB, Shimada T, Kurazono H et al (1994b) Characterization of phenotypic, serological, and toxigenic traits of Vibrio cholerae O139 Bengal. J Clin Microbiol 32:2775–2779
Nandi S, Khetawat G, Sengupta S et al (1997) Rearrangements in the genomes of Vibrio cholerae strains belonging to different serovars and biovars. Int J Syst Bacteriol 47:858–862
Narang P, Mendiratta DK, Kannathe J, Ramnani VK, Wasekar V, Deotale V (1994) Characteristics of Vibrio cholerae O139 strains isolated in Sevagram (Maharashtra) during April-August 1993. Indian J Med Res 99:103–104
Neogy KN, Chatterjee BD (1970) Reappearance of classical V. cholerae in Calcutta during early 1970. Bull Calcutta Sch Trop Med 18:52
Niyogi GS, Deb BC, Sircar BK et al (1979) Studies on cholera carriers and their role in transmission of the infection: a preliminary report. Indian J Med Res 70:892–897
Niyogi SK, Mondal S, Sarkar BL, Garg S, Banerjee D, Dey GN (1994) Outbreak of cholera due to Vibrio cholerae O1 in Orissa state. Indian J Med Res 100:217–218
Niyogi SK, Sengupta PG, Bhattacharya SK, Garg S, Mukhapadhayay AK, Nair GB (1995) Emergence of furazolidone and cotrimoxazole resistant Vibrio cholerae O1 in eastern India. J Infect 30:265–266
Pajni S, Sharma C, Bhasin N et al (1995) Studies on the genesis of Vibrio cholerae O139: identification of probable progenitor strains. J Med Microbiol 42:20–25
Pal A, Saha PK, Nair GB et al (1999) Clonal analysis of non-toxigenic Vibrio cholerae O1 associated with an outbreak of cholera. Indian J Med Res 109:208–211
Pal BB, Khuntia HK, Samal SK, Kar SK, Patnaik B (2010) Epidemics of severe cholera caused by El Tor Vibrio cholerae O1 Ogawa possessing the ctxB gene of the classical biotype in Orissa, India. Int J Infect Dis 14:384–389
Pal BB, Khuntia HK, Samal S et al (2013) Large outbreak of cholera caused by El Tor variant Vibrio cholerae O1 in the eastern coast of Odisha, India during 2009. Epidemiol Infect 141:2560–2567
Palit A, Batabyal P (2010) Toxigenic Vibrio cholerae from environmental sources associated with the cholera outbreak after ‘AILA’ cyclone in West Bengal, India. Lett Appl Microbiol 51:241–243
Palit A, Batabyal P, Kanungo S, Sur D (2012) In-house contamination of potable water in urban slum of Kolkata, India: a possible transmission route of diarrhea. Water Sci Technol 66:299–303
Panda S, Pati KK, Bhattacharya MK, Koley H, Pahari S, Nair GB (2011) Rapid situation and response assessment of diarrhoea outbreak in a coastal district following tropical cyclone AILA in India. Indian J Med Res 133:395–400
Panja G, Ghosh SK (1947) Indian J Med Res xxxv:979
Patnaik SK, Shukla P, Verma P, Dixit GC, Pal D, Sharma SN (1989) Outbreak of cholera in Berasia block of Bhopal District in Madhya Pradesh. J Commun Dis 21:123–128
Phukan AC, Borah PK, Biswas D, Mahanta J (2004) A cholera epidemic in a rural area of northeast India. Trans R Soc Trop Med Hyg 98:563–566
Pollitzer R (1959) Cholera. World Health Organization, Geneva, Switzerland
Prabhakar H, Lal M, Kaur H (1994) Outbreak of gastroenteritis due to a new strain of non O group 1 Vibrio cholerae, in Ludhiana in May–August 1993. Indian J Med Res 99:107–108
Prescott LM, Bhattacharjee NK (1969) Viability of El Tor vibrios in common foodstuff found in an endemic cholera area. Bull World Health Organ 40:980–982
Radhakutty G, Sircar BK, Mondal SK et al (1997) Investigation of the outbreak of cholera in Alleppey and Palghat districts, South India. Indian J Med Res 106:455–457
Rajendran K, Sumi A, Bhattachariya MK et al (2011) Influence of relative humidity in Vibrio cholerae infection: a time series model. Indian J Med Res 133:138–145
Rajeshwari K, Gupta A, Dubey AP, Uppal B, Singh MM (2008) Diarrhoeal outbreak of Vibrio cholerae O1 Inaba in Delhi. Trop Doct 38:105–107
Ramamurthy T, Pal A, Nair GB, Pal SC, Takeda T, Takeda Y (1990) Experience with a toxin bead-ELISA in a cholera outbreak. Lancet ii:375–376
Ramamurthy T, Pal A, Bhattacharya MK et al (1992a) Serovar, biotype, phage type, toxigenicity & antibiotic susceptibility patterns of Vibrio cholerae isolated during two consecutive cholera seasons (1989–1990) in Calcutta. Indian J Med Res 95:125–129
Ramamurthy T, Bhattacharya SK, Uesaka Y et al (1992b) Evaluation of the bead enzyme-linked immunosorbent assay for detection of cholera toxin directly from stool specimens. J Clin Microbiol 30:1783–1786
Ramamurthy T, Pal A, Pal SC, Nair GB (1992c) Taxonomical implications of the emergence of high frequency of occurrence of 2,4-diamino-6,7-diisopropylpteridine-resistant strains of Vibrio cholerae from clinical cases of cholera in Calcutta, India. J Clin Microbiol 30:742–743
Ramamurthy T, Garg S, Sharma R et al (1993a) Emergence of novel strain of Vibrio cholerae with epidemic potential in southern and eastern India. Lancet 341:703–704
Ramamurthy T, Pal A, Bag PK et al (1993b) Detection of cholera toxin gene in stool specimens by polymerase chain reaction: comparison with bead enzyme-linked immunosorbent assay and culture method for laboratory diagnosis of cholera. J Clin Microbiol 31:3068–3070
Ramamurthy T, Rajendran K, Garg P et al (2000) Cluster-analysis and patterns of dissemination of multidrug resistance among clinical strains of Vibrio cholerae in Calcutta, India. Indian J Med Res 112:78–85
Rathna K, Khairunnisa, Rajyalakshmi K, Naidu AS (1988) Epidemiological patterns and incidence of bio-, sero- and phage types of Vibrio cholerae in Hyderabad, India, during 1971–1984. Acta Microbiol Hung 35:313–322
Raychoudhuri A, Chatterjee S, Pazhani GP et al (2007) Molecular characterization of recent Vibrio cholerae O1, El Tor, Inaba strains isolated from hospitalized patients in Kolkata, India. J Infect 55:431–438
Rogers L (1926) Proc Roy Soc Med xix:59
Rogers L (1957) Brit Med J ii:1193
Roy S, Dutta B, Ghosh AR et al (2005) Molecular tracking of the lineage of strains of Vibrio cholerae O1 biotype El Tor associated with a cholera outbreak in Andaman and Nicobar Islands, India. Trop Med Int Health 10:604–611
Roy S, Parande MV, Mantur BG et al (2012) Multidrug-resistant Vibrio cholerae O1 in Belgaum, south India. J Med Microbiol 61:1574–1579
Rudra S, Mathur M, Talwar V, Kathuria K et al (1997) Changing patterns of Vibrio cholerae isolation over three consecutive cholera seasons (1992–1994) in east Delhi. J Commun Dis 29:15–22
Russell AJH (1927) Trans Far East Assoc Trop Med ii:131
Sabherwal U, Sikka R (1994) Emergence of Vibrio cholerae serogroup O139 in Haryana in May–June 1993. Indian J Med Res 99:105–106
Sachdeva V, Khanna KK, Singh M, Singh J, Kumari S, Verghese T (1995) Widespread emergence of Vibrio cholerae O139 in India. Southeast Asian J Trop Med Public Health 26:342–346
Sack RB (1992) Colonization and pathology. In: Barua D, Greenough WB (eds) Cholera. Plenum Medical Book Co., New York, pp 189–197
Sack RB, Barua D (1964) The fluorescent antibody technique in the diagnosis of cholera. Indian J Med Res 52:848–854
Saha A, Deb R, Shah S et al (2006) PCR-based identification of Vibrio cholerae and the closely related species Vibrio mimicus using the large chromosomal ori sequence of Vibrio cholerae. FEMS Microbiol Lett 257:84–91
Saha PK, Koley H, Mukhopadhyay AK et al (1996) Nontoxigenic Vibrio cholerae O1 serotype Inaba biotype El Tor associated with a cluster of cases of cholera in southern India. J Clin Microbiol 34:1114–1117
Samal B, Ghosh SK, Mohanty SK, Patnaik K (2001) Epidemic of Vibrio cholerae serogroup O139 in Berhampur, Orissa. Indian J Med Res 114:10–11
Sarkar BL, Kanungo S, Nair GB (2012) How endemic is cholera in India? Indian J Med Res 135:246–248
Saraswathi K, Deodhar LP (1990) A study of V. cholerae strains isolated in Bombay. J Postgrad Med 36:128–130
Sasmal D, Ganguly R (1971) Studies on intestopan resistant vibrios. Indian J Med Res 59:526
Sehgal PN, Misra BS, Pal SC et al (1972) An epidemic of classical cholera in the south eastern districts of Madhya Pradesh in 1970. Indian J Med Res 60:7–14
Sekar R, Amudhan M, Sivashankar M, Mythily N, Mythreyee M (2012) An outbreak of cholera among a rural population in south India: is it time to vaccinate the children in endemic areas? Indian J Med Res 135:678–679
Sengupta PG, Sircar BK, Mandal S et al (1978) Effect of doxycyline on transmission of Vibrio cholerae infection amongst family contacts of cholera patients in Calcutta. Bull World Health Organ 56:323–326
Sengupta PG, Sircar BK, Mandal SK et al (1995) Epidemiology of Vibrio cholerae O139 with special reference to intrafamilial transmission in Calcutta. J Infect 31:45–47
Sengupta PG, Niyogi SK, Bhattacharya SK (2000) An outbreak of Eltor cholera in Aizwal town of Mizoram, India. J Commun Dis 32:207–211
Sethi NK, Sethi SK (2001) Vibrio cholerae diarrhoea in a three-day-old breastfed neonate. Indian J Pediatr 68:791–792
Shah WA, Shahina M, Ali N (2002) First report of Vibrio cholerae infection from Andaman and Nicobar, India. J Commun Dis 34:270–275
Shah HD, Shah VP, Desai AN (2012) An epidemic outbreak of Vibrio cholerae El Tor O1 serotype Ogawa biotype in a Lalpur town, Jamnagar, India. J Postgrad Med 58:14–18
Sharma MID (1975) Problem of Cholera in India. J Com Dis 7:79–83
Sharma C, Ghosh A, Ghosh RK, Mukhopadhyay AK, Nair GB (1998) Molecular analysis of the cholera toxin gene and antibiotic sensitivity profile of Vibrio cholerae O1 and O139 associated with mixed infection. Indian J Med Res 107:199–203
Sharma C, Maiti S, Mukhopadhyay AK et al (1997a) Unique organization of the CTX genetic element in Vibrio cholerae O139 strains which reemerged in Calcutta, India, in September 1996. J Clin Microbiol 35:3348–3350
Sharma C, Nair GB, Mukhopadhyay AK, Bhattacharya SK, Ghosh RK, Ghosh A (1997b) Molecular characterization of Vibrio cholerae O1 biotype El Tor strains isolated between 1992 and 1995 in Calcutta, India: evidence for the emergence of a new clone of the El Tor biotype. J Infect Dis 175:1134–1141
Shi L, Fujihara K, Sato T et al (2006) Distribution and characterization of integrons in various serogroups of Vibrio cholerae strains isolated from diarrhoeal patients between 1992 and 2000 in Kolkata, India. J Med Microbiol 55:575–583
Shirai H, Nishibuchi M, Ramamurthy T, Bhattacharya SK, Pal SC, Takeda Y (1991) Polymerase chain reaction for detection of the cholera enterotoxin operon of Vibrio cholerae. J Clin Microbiol 29:2517–2521
Simpson WJ (1888) Cholera and its fostering conditions within the endemic area. BMJ II:416
Singh YI, Singh TS, Devi U, Singh NB (1986) Cholera outbreak in Manipur. J Commun Dis 18:9–112
Singh J, Khanna KK, Dhariwal AC et al (1996a) Unusual occurrence of cholera in Delhi during January 1994: epidemiological investigations. J Diarrhoeal Dis Res 14:107–109
Singh J, Bora D, Khanna KK et al (1996b) Epidemiology and transmission of V. cholerae O1 and V. cholerae O139 infections in Delhi in 1993. J Diarrhoeal Dis Res 14:182–186
Singh J, Bora D, Sachdeva V, Sharma RS, Verghese T (1997) Vibrio cholerae O1 and O139 in less than five years old children hospitalised for watery diarrhoea in Delhi, 1993. J Diarrhoeal Dis Res 15:3–6
Singh J, Sachdeva V, Bhatia R, Bora D, Jain DC, Sokhey J (1998) Endemic cholera in Delhi, 1995: analysis of data from a sentinel centre. J Diarrhoeal Dis Res 16:66–73
Sinha R, Deb BC, Ghosh AK, Shrivastava DL (1969) Virulence of Vibrio cholerae strains isolated from carriers in the rabbit ileal loop. Indian J Med Res 57:1636
Sinha S, Chowdhury P, Chowdhury NR et al (2001) Molecular comparison of toxigenic clinical & non-toxigenic environmental strains of Vibrio cholerae O1 Ogawa isolated during an outbreak of cholera in south India. Indian J Med Res 114:83–89
Sinha S, Chakraborty R, De K et al (2002) Escalating association of Vibrio cholerae O139 with cholera outbreaks in India. J Clin Microbiol 40:2635–2637
Sinha A, Sengupta S, Ghosh S et al (2012) Evaluation of a rapid dipstick test for identifying cholera cases during the outbreak. Indian J Med Res 135:523–528
Sircar BK, Saha MR, Deb BC, Singh PK, Pal SC (1990) Effectiveness of oral rehydration salt solution (ORS) in reduction of death during cholera epidemic. Indian J Public Health 34:68–70
Slathia P, Bansal MP (1999) Incidence of Vibrio cholerae in different age groups and sex in Aurangabad. Province isolated during January 1994 to December 1994. Indian J Med Sci 53:349–351
Soni GS, Gupta BL, Gupta U, Joshi KR (1989) An outbreak of El Tor cholera in rural population of Barmer in Rajasthan State of India, Aug–Sep 1987. Indian J Public Health 33:77–78
Sugunan AP, Roy S, Shahina M et al (2007) Emergence of Vibrio cholerae O1 Inaba in Andaman & Nicobar Islands, India. J Public Health 29:308–309
Sundaram SP, Revathi J, Elango V, Shanthakumari SL (1998) Aetiology of cholera in Tamil Nadu: recent observations. Trans R Soc Trop Med Hyg 92:164–165
Sundaram SP, Revathi J, Sarkar BL, Bhattacharya SK (2002) Bacteriological profile of cholera in Tamil Nadu (1980–2001). Indian J Med Res 116:258–263
Sur D, Dutta P, Nair GB, Bhattacharya SK (2000) Severe cholera outbreak following floods in a northern district of West Bengal. Indian J Med Res 112:178–182
Sur D, Sengupta PG, Mondal SK et al (2002) A localised outbreak of Vibrio cholerae O139 in Kolkata, West Bengal. Indian J Med Res 115:149–152
Sur D, Deen JL, Manna B et al (2005) The burden of cholera in the slums of Kolkata, India: data from a prospective, community based study. Arch Dis Child 90:1175–1181
Sur D, Kanungo S, Sah B et al (2011) Efficacy of a low-cost, inactivated whole-cell oral cholera vaccine: results from 3 years of follow-up of a randomized, controlled trial. PLoS Negl Trop Dis 5:e1289
Swaroop S, Pollitzer R (1955) Bull World Health Organ xii:311
Taneja N, Kaur J, Sharma K et al (2003) A recent outbreak of cholera due to Vibrio cholerae O1 Ogawa in & around Chandigarh, North India. Indian J Med Res 117:243–246
Taneja N, Biswal M, Tarai B, Sharma M (2005) Emergence of Vibrio cholerae O1 Biotype El Tor Serotype Inaba in North India. Jpn J Infect Dis. 58:238–240
Taneja N, Sangar G, Chowdhury G et al (2012) Molecular epidemiology of Vibrio cholerae causing outbreaks & sporadic cholera in northern India. Indian J Med Res 136:656–663
Thakur JS, Swami HM, Dutt R, Mehta M, Gupta V (2001) Epidemiological investigation of cholera outbreak in a periurban slum colony in Chandigarh. Indian J Med Sci 55:429–433
Thungapathra M, Amita Sinha KK et al (2002) Occurrence of antibiotic resistance gene cassettes aac(6′)-Ib, dfrA5, dfrA12, and ereA2 in class I integrons in non-O1, non-O139 Vibrio cholerae strains in India. Antimicrob Agents Chemother 46:2948–2955
Tilak VW, Bhalwar R, Ratti JS (1997) Epidemiological study of an outbreak of cholera in Delhi cantonment. Indian J Public Health 41:61–67
Uppal B, Berry N, Kakar S, Ramji S, Mathur MD (1999) Vibrio cholerae O1 serotype Ogawa in a neonate. Diagn Microbiol Infect Dis 33:63–64
Verenkar M, Savio R, Venkatesh N, Pinto MJ, Singh I (1994) Cholera epidemic in Goa. Indian J Pathol Microbiol 37:289–292
Verma R, Khanna P, Chawla S (2012) Cholera vaccine: new preventive tool for endemic countries. Hum Vaccin Immunother 8:682–684
Vijayalakshmi N, Rao RS, Sujatha S, Hamid A, Dutta TK, Das AK (1994) An outbreak of gastroenteritis due to Vibrio cholerae O139 in Pondicherry, South India. Southeast Asian J Trop Med Public Health 25:314–315
Vijayalakshmi N, Rao RS, Badrinath S (1997) Minimum inhibitory concentration (MIC) of some antibiotics against Vibrio cholerae O139 isolates from Pondicherry. Epidemiol Infect 119:25–28
Walsh TR, Weeks J, Livermore DM, Toleman MA (2011) Dissemination of NDM-1 positive bacteria in the New Delhi environment and its implications for human health: an environmental point prevalence study. Lancet Infect Dis 11:355–362
Wozniak RA, Waldor MK (2010) Integrative and conjugative elements: mosaic mobile genetic elements enabling dynamic lateral gene flow. Nat Rev Microbiol 8:552–563
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Ramamurthy, T., Sharma, N.C. (2014). Cholera Outbreaks in India. In: Nair, G., Takeda, Y. (eds) Cholera Outbreaks. Current Topics in Microbiology and Immunology, vol 379. Springer, Berlin, Heidelberg. https://doi.org/10.1007/82_2014_368
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