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Clinical Safety and Pharmacology Trial

  • Christine MauckEmail author
  • Andrea Thurman
  • Jill Schwartz
Chapter
  • 592 Downloads
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 383)

Abstract

Guidelines for establishing clinical safety of microbicides in early clinical studies have evolved significantly since the first trials. In addition, because of the difficulty of establishing efficacy of a microbicide prior to Phase III testing, there has been an increasing emphasis on establishing pharmacokinetic (PK)/pharmacodynamic (PD) relationships using genital samples collected in vivo in Phase I studies. A healthy pipeline is critical to success; however, it is unlikely that the majority of microbicide candidates will progress to clinical testing. Those that do enter clinical testing may have different mechanisms of action than early candidates. Given this, drug-specific modifications for early clinical assessment will need to be considered. These emerging issues associated with early clinical trials of microbicides will be reviewed, along with recommendations for future clinical safety and PK/PD evaluation.

Keywords

Bacterial Vaginosis Secretory Leukocyte Protease Inhibitor Vaginal Tissue Lower Genital Tract Trichomonas Vaginalis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Christine Mauck
    • 1
    Email author
  • Andrea Thurman
    • 2
  • Jill Schwartz
    • 1
  1. 1.CONRADArlingtonUSA
  2. 2.Department of Obstetrics and GynecologyCONRADNorfolkUSA

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