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Facets of Small RNA-Mediated Regulation in Legionella pneumophila

  • Hana Trigui
  • Nilmini Mendis
  • Laam Li
  • Mariam Saad
  • Sebastien P. Faucher
Chapter
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 376)

Abstract

Legionella pneumophila is a water-borne pathogen that causes a severe lung infection in humans. It is able to replicate inside amoeba in the water environment, and inside lung macrophages in humans. Efficient regulation of gene expression is critical for responding to the conditions that L. pneumophila encounters and for intracellular multiplication in host cells. In the last two decades, many reports have contributed to our understanding of the critical importance of small regulatory RNAs (sRNAs) in the regulatory network of bacterial species. This report presents the current state of knowledge about the sRNAs expressed by L. pneumophila and discusses a few regulatory pathways in which sRNAs should be involved in this pathogen.

Keywords

Ribosomal Binding Site Small Regulatory RNAs mRNA Interaction Translation Initiation Region Pontiac Fever 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

Our research is supported by FRQNT Établissement de nouveaux chercheurs grant 2013-NC-164725 and NSERC Discovery grant 418289-2012. We would like to thank the reviewers for helpful suggestions.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Hana Trigui
    • 1
  • Nilmini Mendis
    • 1
  • Laam Li
    • 1
  • Mariam Saad
    • 1
  • Sebastien P. Faucher
    • 1
  1. 1.Faculty of Agricultural and Environmental Sciences, Department of Natural Resource SciencesMcGill UniversitySte-Anne-de-BellevueCanada

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