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Facets of Small RNA-Mediated Regulation in Legionella pneumophila

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Molecular Mechanisms in Legionella Pathogenesis

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 376))

Abstract

Legionella pneumophila is a water-borne pathogen that causes a severe lung infection in humans. It is able to replicate inside amoeba in the water environment, and inside lung macrophages in humans. Efficient regulation of gene expression is critical for responding to the conditions that L. pneumophila encounters and for intracellular multiplication in host cells. In the last two decades, many reports have contributed to our understanding of the critical importance of small regulatory RNAs (sRNAs) in the regulatory network of bacterial species. This report presents the current state of knowledge about the sRNAs expressed by L. pneumophila and discusses a few regulatory pathways in which sRNAs should be involved in this pathogen.

The first two authors, Hana Trigui and Nilmini Mendis, have contributed equally to this work.

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Acknowledgments

Our research is supported by FRQNT Établissement de nouveaux chercheurs grant 2013-NC-164725 and NSERC Discovery grant 418289-2012. We would like to thank the reviewers for helpful suggestions.

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  1. Faculty of Agricultural and Environmental Sciences, Department of Natural Resource Sciences, McGill University, Ste-Anne-de-Bellevue, QC, H9X 3V9, Canada

    Hana Trigui, Nilmini Mendis, Laam Li, Mariam Saad & Sebastien P. Faucher

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  1. Hana Trigui
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  2. Nilmini Mendis
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  3. Laam Li
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  4. Mariam Saad
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  5. Sebastien P. Faucher
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Correspondence to Sebastien P. Faucher .

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  1. Max von Pettenkofer Institute, Ludwig-Maximilians University München, Munich, Germany

    Hubert Hilbi

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Trigui, H., Mendis, N., Li, L., Saad, M., Faucher, S.P. (2013). Facets of Small RNA-Mediated Regulation in Legionella pneumophila . In: Hilbi, H. (eds) Molecular Mechanisms in Legionella Pathogenesis. Current Topics in Microbiology and Immunology, vol 376. Springer, Berlin, Heidelberg. https://doi.org/10.1007/82_2013_347

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