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Pathogenesis of Mycobacterium tuberculosis and its Interaction with the Host Organism pp 109–134Cite as

Getting Across the Cell Envelope: Mycobacterial Protein Secretion

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Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 374))

Abstract

Protein secretion is an essential determinant of mycobacterial virulence. Mycobacterium tuberculosis has a unique cell envelope consisting of two lipid bilayers, which requires dedicated protein secretion pathways. The conserved general Sec and Tat translocation systems are responsible for protein transport across the inner membrane and are both essential. Additionally, the accessory Sec pathway specifically contributes to virulence. How transport of Sec/Tat substrates across the outer membrane is accomplished is currently an enigma. In addition to these pathways, M. tuberculosis also developed specialized secretion systems for protein transport across both membranes, the type VII or ESX secretion systems. Here, we discuss our current knowledge about the mechanisms and substrates of these different protein translocation systems and their role in mycobacterial physiology and virulence.

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Authors and Affiliations

  1. Department of Molecular Microbiology, Institute of Molecular Cell Biology, VU University, Amsterdam, The Netherlands

    Aniek D. van der Woude, Joen Luirink & Wilbert Bitter

  2. Department of Medical Microbiology and Infection Control, VU University Medical Center, Amsterdam, The Netherlands

    Aniek D. van der Woude, Joen Luirink & Wilbert Bitter

Authors
  1. Aniek D. van der Woude
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  2. Joen Luirink
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  3. Wilbert Bitter
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Correspondence to Wilbert Bitter .

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Editors and Affiliations

  1. Biozentrum, University of Basel, Basel, Switzerland

    Jean Pieters

  2. Laboratory of Microbiology and Microsystems, Swiss Federal Institute of Technology Lausanne (EPFL), Lausanne, Switzerland

    John D. McKinney

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van der Woude, A.D., Luirink, J., Bitter, W. (2012). Getting Across the Cell Envelope: Mycobacterial Protein Secretion. In: Pieters, J., McKinney, J. (eds) Pathogenesis of Mycobacterium tuberculosis and its Interaction with the Host Organism. Current Topics in Microbiology and Immunology, vol 374. Springer, Berlin, Heidelberg. https://doi.org/10.1007/82_2012_298

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