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Host–Pathogen Interactions in Streptococcal Immune Sequelae

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Host-Pathogen Interactions in Streptococcal Diseases

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 368))

Abstract

Otherwise uncomplicated infections with Streptococcus pyogenes can cause two insidious immune sequelae known as post-streptococcal glomerulonephritis (PSGN) and acute rheumatic fever (ARF). These diseases follow with a latency of a few weeks or months after primary infection and are responsible for high mortality and morbidity. PSGN has also been linked to infections with group C streptococci of the species S. equi ssp. zooepidemicus (SESZ). Moreover, there are some indications that infection with group C and G streptococci (GCGS) of the subspecies Streptococcus dysgalactiae ssp. equisimilis (SDSE) leads to ARF. Despite decades of research, the picture of the molecular pathogenesis of streptococcal immune sequelae resembles a jigsaw puzzle. Herein we try to put some of the puzzle bits together that have been collected till date.

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  1. Department of Medical Microbiology, Helmholtz Centre for Infection Research, D-38124, Braunschweig, Germany

    Gursharan S. Chhatwal

  2. Helmholtz Centre for Infection Research, Inhoffenstraße 7, D-38124, Braunschweig, Germany

    D. Patric Nitsche-Schmitz

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Correspondence to D. Patric Nitsche-Schmitz .

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  1. , Dept. of Medical Microbiology, Helmholtz Centre for Infection Research, Inhoffenstr. 7, Braunschweig, 38124, Germany

    G. Singh Chhatwal

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Nitsche-Schmitz, D.P., Chhatwal, G.S. (2012). Host–Pathogen Interactions in Streptococcal Immune Sequelae. In: Chhatwal, G. (eds) Host-Pathogen Interactions in Streptococcal Diseases. Current Topics in Microbiology and Immunology, vol 368. Springer, Berlin, Heidelberg. https://doi.org/10.1007/82_2012_296

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