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Epigenetics and Regeneration

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New Perspectives in Regeneration

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 367))

Abstract

During newt lens regeneration a unique transdifferentiation event occurs. In this process, dorsal iris pigmented epithelial cells transdifferentiate into lens cells. This system should provide a new insight into cellular plasticity in basic and applied research. Recently, a series of approaches to study epigenetic reprogramming during transdifferentiation have been performed. In this review, we introduce the regulation of dynamic regulation of core-histone modifications and the emergence of an oocyte-type linker histone during transdifferentiation. Finally, we show supporting evidence that there are common strategies of reprogramming between newt somatic cell in transdifferentiation and oocytes after somatic cell nuclear transfer.

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Acknowledgments

We would like to thank Kiyoe Ura for critical reading and suggestions, and Rinako Maki for making illustrations.

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Authors and Affiliations

  1. Institute of Protein Research, Osaka University, 3-2 Yamadaoka, Suita-Shi, Osaka, 565-0871, Japan

    Nobuyasu Maki & Hironobu Kimura

  2. PRESTO, Japan Science and Technology Agency, 4-1-8 Honcho, Kawaguchi, Saitama, 332-0012, Japan

    Nobuyasu Maki

Authors
  1. Nobuyasu Maki
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  2. Hironobu Kimura
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Correspondence to Nobuyasu Maki .

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Editors and Affiliations

  1. Wistar Institute, Spruce Street 3601, Philadelphia, 19104, Pennsylvania, USA

    Ellen Heber-Katz

  2. Center for Regenerative Biology and, Medicine, Indiana University, North Blackford Street 402, Indianapolis, 46202, Indiana, USA

    David L. Stocum

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Maki, N., Kimura, H. (2012). Epigenetics and Regeneration. In: Heber-Katz, E., Stocum, D. (eds) New Perspectives in Regeneration. Current Topics in Microbiology and Immunology, vol 367. Springer, Berlin, Heidelberg. https://doi.org/10.1007/82_2012_293

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