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Modulation of the Coagulation System During Severe Streptococcal Disease

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Host-Pathogen Interactions in Streptococcal Diseases

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 368))

Abstract

Haemostasis is maintained by a tightly regulated coagulation system that comprises platelets, procoagulant proteins, and anticoagulant proteins. During the local and systemic response to bacterial infection, the coagulation system becomes activated, and contributes to the pathophysiological response to infection. The significant human pathogen, Streptococcus pyogenes has multiple strategies to modulate coagulation. This can range from systemic activation of the intrinsic and extrinsic pathway of coagulation to local stimulation of fibrinolysis. Such diverse effects on this host system imply a finely tuned host–bacteria interaction. The molecular mechanisms that underlie this modulation of the coagulation system are discussed in this review.

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Authors and Affiliations

  1. Division of Infection Medicine, Department of Clinical Sciences, Biomedical Centre (BMC), B14, Lund University, SE-22184, Lund, Sweden

    Oonagh Shannon

  2. Virology and Hygiene, Medical Faculty, Institute of Medical Microbiology, University of Rostock, Rostock, Germany

    Heiko Herwald & Sonja Oehmcke

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  1. Oonagh Shannon
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  2. Heiko Herwald
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Correspondence to Oonagh Shannon .

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  1. , Dept. of Medical Microbiology, Helmholtz Centre for Infection Research, Inhoffenstr. 7, Braunschweig, 38124, Germany

    G. Singh Chhatwal

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Shannon, O., Herwald, H., Oehmcke, S. (2012). Modulation of the Coagulation System During Severe Streptococcal Disease. In: Chhatwal, G. (eds) Host-Pathogen Interactions in Streptococcal Diseases. Current Topics in Microbiology and Immunology, vol 368. Springer, Berlin, Heidelberg. https://doi.org/10.1007/82_2012_283

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