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Notch Signaling During Human T cell Development

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Book cover Notch Regulation of the Immune System

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 360))

Abstract

Notch signaling is critical during multiple stages of T cell development in both mouse and human. Evidence has emerged in recent years that this pathway might regulate T-lineage differentiation differently between both species. Here, we review our current understanding of how Notch signaling is activated and used during human T cell development. First, we set the stage by describing the developmental steps that make up human T cell development before describing the expression profiles of Notch receptors, ligands, and target genes during this process. To delineate stage-specific roles for Notch signaling during human T cell development, we subsequently try to interpret the functional Notch studies that have been performed in light of these expression profiles and compare this to its suggested role in the mouse.

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Acknowledgments

The authors wish to thank Jean Plum for critical reading of the manuscript. Work on this subject by the Taghon lab is funded by a research grant from the Fund for Scientific Research Flanders (FWO), as well as by its Odysseus program. IVdW is supported by a grant from the Special Fund for Scientific Research (BOF) of the Ghent University and TT by a fellowship of the FWO.

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Authors and Affiliations

  1. Department of Clinical Chemistry, Microbiology and Immunology, Ghent University Hospital, Ghent University, 9000, Ghent, Belgium

    Tom Taghon, Els Waegemans & Inge Van de Walle

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  1. Tom Taghon
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  2. Els Waegemans
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  3. Inge Van de Walle
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Correspondence to Tom Taghon .

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  1. , EPFL SV ISREC UPRAD, University of Lausanne, Lausanne, 1015, Switzerland

    Freddy Radtke

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Taghon, T., Waegemans, E., Van de Walle, I. (2012). Notch Signaling During Human T cell Development. In: Radtke, F. (eds) Notch Regulation of the Immune System. Current Topics in Microbiology and Immunology, vol 360. Springer, Berlin, Heidelberg. https://doi.org/10.1007/82_2012_230

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