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Notch Signaling in Alloreactive T Cell Immunity

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Notch Regulation of the Immune System

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 360))

Abstract

Alloreactive T cell immunity mediates the recognition of foreign tissue antigens in recipients of organ transplants. After solid organ transplantation, activation of host T cells by donor alloantigens can trigger rejection of the implanted organ. Global life-long immunosuppression is necessary to prevent or to minimize organ rejection. After bone marrow or hematopoietic cell transplantation (allo-BMT), donor-derived T cells recognize host alloantigens, inducing both beneficial graft-versus-tumor (GVT) effects as well as detrimental graft-versus-host disease (GVHD). Preventing GVHD without eliminating GVT activity is an essential goal to maximize the safety and efficacy of allo-BMT. In this review, we discuss emerging findings that have identified the Notch pathway as a central player in the regulation of T cell alloimmunity. In view of these effects, Notch signaling in T cells should be considered as an attractive new therapeutic target to achieve beneficial immunomodulation following allo-BMT and other types of allogeneic transplantation.

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Acknowledgments

Work on Notch signaling in the Maillard laboratory has been supported by a Damon Runyon Rachleff Innovation award, a Scholar award from the American Society of Hematology and funding from the National Institutes of Health (RO1 AI091627).

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Authors and Affiliations

  1. Life Sciences Institute, ⌦, ⌦

    Jooho Chung & Ivan Maillard

  2. Cellular and Molecular Biology Program, ⌦, ⌦

    Jooho Chung & Ivan Maillard

  3. Department of Medicine, Division of Hematology-Oncology, ⌦, ⌦

    Ivan Maillard

  4. Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, 48104, USA

    Ivan Maillard

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  1. Jooho Chung
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Correspondence to Ivan Maillard .

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  1. , EPFL SV ISREC UPRAD, University of Lausanne, Lausanne, 1015, Switzerland

    Freddy Radtke

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Chung, J., Maillard, I. (2012). Notch Signaling in Alloreactive T Cell Immunity. In: Radtke, F. (eds) Notch Regulation of the Immune System. Current Topics in Microbiology and Immunology, vol 360. Springer, Berlin, Heidelberg. https://doi.org/10.1007/82_2012_226

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