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Henipavirus pp 95–104Cite as

Clinical and Pathological Manifestations of Human Henipavirus Infection

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Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 359))

Abstract

The clinicopathological features of human Nipah virus and Hendra virus infections appear to be similar. The clinical manifestations may be mild, but if severe, includes acute encephalitic and pulmonary syndromes with a high mortality. The pathological features in human acute henipavirus infections comprise vasculopathy (vasculitis, endothelial multinucleated syncytia, thrombosis), microinfarcts and parenchymal cell infection in the central nervous system, lung, kidney and other major organs. Viral inclusions, antigens, nucleocapsids and RNA are readily demonstrated in blood vessel wall and numerous types of parenchymal cells. Relapsing henipavirus encephalitis is a rare complication reported in less than 10% of survivors of the acute infection and appears to be distinct from the acute encephalitic syndrome. Pathological evidence suggests viral recrudescence confined to the central nervous system as the cause.

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Acknowledgments

The authors acknowledge the extensive assistance from colleagues, clinicians, students and fellow scientists in Malaysia and around the world in our investigations of henipavirus infections. The support of R&D grants from the Malaysian Government is also gratefully acknowledged.

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Authors and Affiliations

  1. Deptartment of Pathology, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia

    K. T. Wong

  2. Department of Medicine, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia

    C. T. Tan

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  1. K. T. Wong
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  2. C. T. Tan
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Correspondence to K. T. Wong .

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Editors and Affiliations

  1. , Dept. of Microbiol., Immunol., Mol. Gen., David Geffen School of Medicine, Charles E. Young Drive East 615, Los Angeles, 90095-1489, California, USA

    Benhur Lee

  2. MS-C-22, 1600 Clifton Road, Atlanta, 30329, Georgia, USA

    Paul A. Rota

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© 2012 Springer-Verlag Berlin Heidelberg

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Wong, K.T., Tan, C.T. (2012). Clinical and Pathological Manifestations of Human Henipavirus Infection. In: Lee, B., Rota, P. (eds) Henipavirus. Current Topics in Microbiology and Immunology, vol 359. Springer, Berlin, Heidelberg. https://doi.org/10.1007/82_2012_205

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