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Interaction of Ricin and Shiga Toxins with Ribosomes

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Book cover Ricin and Shiga Toxins

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 357))

Abstract

Ricin and Shiga toxins designated as ribosome inactivating proteins (RIPs) are RNA N-glycosidases that depurinate a specific adenine (A4324 in rat 28S rRNA) in the conserved α-sarcin/ricin loop of the large rRNA, inhibiting protein synthesis. Evidence obtained from a number of studies suggests that interaction with ribosomal proteins plays an important role in the catalytic activity and ribosome specificity of RIPs. This review summarizes the recent developments in identification of the ribosomal proteins that interact with ricin and Shiga toxins and the principles governing these interactions.

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Acknowledgments

This work was supported by National Institutes of Health grants AI072425 and AI082120.

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Authors and Affiliations

  1. Department of Plant Biology and Pathology, School of Environmental and Biological Sciences, Rutgers University, 59 Dudley Road, New Brunswick, NJ, 08901-8520, USA

    Nilgun E. Tumer & Xiao-Ping Li

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  1. Nilgun E. Tumer
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  2. Xiao-Ping Li
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Correspondence to Nilgun E. Tumer .

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  1. , Division of Infectious Diseases, NYDOH, Wadsworth Center, New Scotland Ave 120, Albany, 12208, New York, USA

    Nicholas Mantis

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© 2011 Springer-Verlag Berlin Heidelberg

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Tumer, N.E., Li, XP. (2011). Interaction of Ricin and Shiga Toxins with Ribosomes. In: Mantis, N. (eds) Ricin and Shiga Toxins. Current Topics in Microbiology and Immunology, vol 357. Springer, Berlin, Heidelberg. https://doi.org/10.1007/82_2011_174

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