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Dry Powder Vaccines for Mucosal Administration: Critical Factors in Manufacture and Delivery

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Mucosal Vaccines

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 354))

Abstract

Dry powder vaccine formulations have proved effective for induction of systemic and mucosal immune responses. Here we review the use of dry vaccines for immunization in the respiratory tract. We discuss techniques for powder formulation, manufacture, characterization and delivery in addition to methods used for evaluation of stability and safety. We review the immunogenicity and protective efficacy of dry powder vaccines as compared to liquid vaccines delivered by mucosal or parenteral routes. Included is information on mucosal adjuvants and mucoadhesives that can be used to enhance nasal or pulmonary dry vaccines. Mucosal immunization with dry powder vaccines offers the potential to provide a needle-free and cold chain-independent vaccination strategy for the induction of protective immunity against either systemic or mucosal pathogens.

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Authors and Affiliations

  1. Division of Molecular Pharmaceutics, School of Pharmacy, University of North Carolina, Chapel Hill, NC, 27599, USA

    Sheena H. Wang & Anthony J. Hickey

  2. Department of Pathology, Duke University Medical Center, Durham, NC, 27710, USA

    Afton L. Thompson & Herman F. Staats

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  1. Sheena H. Wang
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  4. Herman F. Staats
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Correspondence to Herman F. Staats .

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    Pamela A. Kozlowski

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Wang, S.H., Thompson, A.L., Hickey, A.J., Staats, H.F. (2011). Dry Powder Vaccines for Mucosal Administration: Critical Factors in Manufacture and Delivery. In: Kozlowski, P. (eds) Mucosal Vaccines. Current Topics in Microbiology and Immunology, vol 354. Springer, Berlin, Heidelberg. https://doi.org/10.1007/82_2011_167

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