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Epigenetic Features that Regulate IgH Locus Recombination and Expression

  • Ramesh Subrahmanyam
  • Ranjan SenEmail author
Chapter
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 356)

Abstract

Precisely regulated rearrangements that yield imprecise recombination junctions are hallmarks of antigen receptor gene assembly. At the immunoglobulin heavy chain (IgH) gene locus this is initiated by rearrangement of a D H gene segment to a J H gene segment to generate DJH junctions, followed by rearrangement of a V H gene segment to the DJH junction to generate fully recombined VDJ alleles. In this review we discuss the regulatory features of each step of IgH gene assembly and the role of epigenetic mechanisms in achieving regulatory precision.

Keywords

Gene Segment Gene Recombination Locus Compaction Epigenetic Feature Distal Versus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

The authors are supported by the Intramural Research Program of the National Institute on Aging, Baltimore, MD.

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Authors and Affiliations

  1. 1.Gene Regulation Section, Laboratory of Molecular Biology and ImmunologyNational Institute on Aging, National Institutes of HealthBaltimoreUSA

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