Epigenetic Features that Regulate IgH Locus Recombination and Expression
Precisely regulated rearrangements that yield imprecise recombination junctions are hallmarks of antigen receptor gene assembly. At the immunoglobulin heavy chain (IgH) gene locus this is initiated by rearrangement of a D H gene segment to a J H gene segment to generate DJH junctions, followed by rearrangement of a V H gene segment to the DJH junction to generate fully recombined VDJ alleles. In this review we discuss the regulatory features of each step of IgH gene assembly and the role of epigenetic mechanisms in achieving regulatory precision.
KeywordsGene Segment Gene Recombination Locus Compaction Epigenetic Feature Distal Versus
The authors are supported by the Intramural Research Program of the National Institute on Aging, Baltimore, MD.
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