B Lymphocyte Lineage Specification, Commitment and Epigenetic Control of Transcription by Early B Cell Factor 1

  • James HagmanEmail author
  • Julita Ramírez
  • Kara Lukin
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 356)


Early B cell factor 1 (EBF1) is a transcription factor that is critical for both B lymphopoiesis and B cell function. EBF1 is a requisite component of the B lymphocyte transcriptional network and is essential for B lineage specification. Recent studies revealed roles for EBF1 in B cell commitment. EBF1 binds its target genes via a DNA-binding domain including a unique ‘zinc knuckle’, which mediates a novel mode of DNA recognition. Chromatin immunoprecipitation of EBF1 in pro-B cells defined hundreds of new, as well as previously identified, target genes. Notably, expression of the pre-B cell receptor (pre-BCR), BCR and PI3K/Akt/mTOR signaling pathways is controlled by EBF1. In this review, we highlight these current developments and explore how EBF1 functions as a tissue-specific regulator of chromatin structure at B cell-specific genes.


Histone Modification Lineage Commitment Lineage Priming Cell Program Chain Gene Rearrangement 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



J.R. was supported by NIH Post-doctoral Training Grant T32 AI07405. J.H. is generously supported by NIH grants R01 AI54661, R01 AI81878 and P01 AI22295.


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© Springer-Verlag Berlin Heidelberg 2011

Authors and Affiliations

  1. 1.Integrated Department of ImmunologyNational Jewish Health and University of Colorado School of MedicineDenverUSA

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