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Hydrogen-Bonded Synthetic Mimics of Protein Secondary Structure as Disruptors of Protein-Protein Interactions

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Small-Molecule Inhibitors of Protein-Protein Interactions

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 348))

Abstract

Small molecules which can mimic the key structural facets of protein secondary structure, in particular the α-helix, β-strand, and β-sheet, have been shown to be potent disruptors of protein–protein interactions. Researchers have recently taken the organizational imitation of protein secondary structure to a new level by using intramolecular hydrogen bonds as stabilizing forces in these small molecule mimetics. The inclusion of these interactions invokes a conformational bias of the system, allowing for greater control of the appearance, and thus often function, of these molecules by design.

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Authors and Affiliations

  1. Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, UK

    Marc J. Adler, Andrew G. Jamieson & Andrew D. Hamilton

Authors
  1. Marc J. Adler
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  2. Andrew G. Jamieson
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  3. Andrew D. Hamilton
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Correspondence to Andrew D. Hamilton .

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Editors and Affiliations

  1. Roche Research Center, Dept. Discovery Oncology, Hoffmann-La Roche Inc., Kingsland Street 340, Nutley, 07110-1199, New Jersey, USA

    Lyubomir Vassilev

  2. Roche Research Center, Dept. of Discovery Oncology, Hoffmann-La Roche Inc., Kingsland Street 340, Nutley, 07110, New Jersey, USA

    David Fry

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Adler, M.J., Jamieson, A.G., Hamilton, A.D. (2010). Hydrogen-Bonded Synthetic Mimics of Protein Secondary Structure as Disruptors of Protein-Protein Interactions. In: Vassilev, L., Fry, D. (eds) Small-Molecule Inhibitors of Protein-Protein Interactions. Current Topics in Microbiology and Immunology, vol 348. Springer, Berlin, Heidelberg. https://doi.org/10.1007/82_2010_91

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