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Concepts and Ways to Amplify the Antitumor Immune Response

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Cancer Immunology and Immunotherapy

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 344))

Abstract

In this chapter, a detailed description of how the innate and adaptive immune responses interact with malignant cells is presented. In addition, we discuss how developing tumors establish themselves, and how they benefit on one hand and organize their defense against the immune system on the other hand. New data from three tumor model systems in mice are discussed; in particular, the intricate interactions between the immune cells and the tumor cells are highlighted. With the present data and knowledge, we conclude that a first prerequisite for the combat against tumors is the activation of the innate immune system via external danger signals or damage signals and internal danger signals. The second prerequisite for efficient tumor cell eradication is combined therapeutic approaches of physical, chemical, pharmacological, and immunological origin. Finally, we propose new ways for further investigation of the relationship linking tumor cells and our defense system. It appears mandatory to understand how the malignant cells render the adaptive immune cells tolerant instead of turning them into aggressive effectors and memory cells. Perhaps, the most important thing, for immunologists and clinicians, to understand is that tumor cells must not be viewed just as antigens but much more.

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Acknowledgement

We wish to thank the CNRS, Pierre Fabre Laboratories, the french Association for Research on Cancer ARC and the European Union for grants and financial supports.

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Authors and Affiliations

  1. UMR 2587 CNRS-Pierre Fabre, Institut de Sciences et Technologies du Médicament de Toulouse, 3, rue des Satellites, 31400, Toulouse, France

    Bent Rubin & Jean Edouard Gairin

  2. Faculté de Pharmacie, Université Paul Sabatier, 31400, Toulouse, France

    Jean Edouard Gairin

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  1. Bent Rubin
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  2. Jean Edouard Gairin
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Correspondence to Jean Edouard Gairin .

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  1. , Medical Oncology/Hematologic Neoplasial, Dana-Farber Cancer Institute, Binney Street 44, Boston, 02115, Massachusetts, USA

    Glenn Dranoff

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Rubin, B., Gairin, J.E. (2010). Concepts and Ways to Amplify the Antitumor Immune Response. In: Dranoff, G. (eds) Cancer Immunology and Immunotherapy. Current Topics in Microbiology and Immunology, vol 344. Springer, Berlin, Heidelberg. https://doi.org/10.1007/82_2010_89

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