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Dendritic Cell Subsets as Vectors and Targets for Improved Cancer Therapy

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Cancer Immunology and Immunotherapy

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 344))

Abstract

Current active immunotherapy trials have shown durable tumor regressions in a fraction of patients. However, the clinical efficacy of current vaccines is limited, possibly because tumors skew the immune system by means of myeloid-derived suppressor cells, inflammatory Type 2 T cells and regulatory T cells (Tregs), all of which prevent the generation of effector cells. To improve the clinical efficacy of cancer vaccines in patients with metastatic disease, we need to design novel and improved strategies that can boost adaptive immunity to cancer, help overcome Tregs and allow the breakdown of the immunosuppressive tumor microenvironment. This can be achieved by exploiting the fast increasing knowledge about the dendritic cell (DC) system, including the existence of distinct DC subsets. Critical to the design of better vaccines is the concept of distinct DC subsets and distinct DC activation pathways, all contributing to the generation of unique adaptive immune responses. Such novel DC vaccines will be used as monotherapy in patients with resected disease and in combination with antibodies and/or drugs targeting suppressor pathways and modulation of the tumor environment in patients with metastatic disease.

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Acknowledgments

Dedicated to patients and volunteers who participated in our studies. We thank the former and current members of the Institute for their contributions. Supported by the NIH (P01 CA084514, U19 AIO57234, R01 CA089440 and CA078846), the Dana Foundation, the Susan Komen Foundation, the Baylor Health Care System; the Baylor Health Care System Foundation, the ANRS and the INSERM. KP holds the Michael A. Ramsay Chair for Cancer Immunology Research. JB holds the Caruth Chair for Transplant Immunology Research.

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Authors and Affiliations

  1. Baylor Institute for Immunology Research, 3434 Live Oak, Dallas, TX, 75204, USA

    Karolina Palucka, Hideki Ueno, Lee Roberts & Jacques Banchereau

  2. Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, NY, USA

    Karolina Palucka & Jacques Banchereau

  3. Sammons Cancer Center, Baylor University Medical Center, Dallas, TX, USA

    Joseph Fay

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  1. Karolina Palucka
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  2. Hideki Ueno
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  3. Lee Roberts
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  4. Joseph Fay
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  5. Jacques Banchereau
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Correspondence to Karolina Palucka .

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  1. , Medical Oncology/Hematologic Neoplasial, Dana-Farber Cancer Institute, Binney Street 44, Boston, 02115, Massachusetts, USA

    Glenn Dranoff

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Palucka, K., Ueno, H., Roberts, L., Fay, J., Banchereau, J. (2010). Dendritic Cell Subsets as Vectors and Targets for Improved Cancer Therapy. In: Dranoff, G. (eds) Cancer Immunology and Immunotherapy. Current Topics in Microbiology and Immunology, vol 344. Springer, Berlin, Heidelberg. https://doi.org/10.1007/82_2010_48

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