Abstract
Glycoprotein M (gM) is conserved among herpesviruses. Important features are its 6–8 transmembrane domains without a large extracellular domain, localization to the virion envelope, complex formation with another envelope glycoprotein, glycoprotein N (gN), and role in virion assembly and egress. In varicella-zoster virus (VZV), the gM homolog is encoded by ORF50. VZV gM is predicted to be an eight-transmembrane envelope glycoprotein with a complex N-linked oligosaccharide. It mainly localizes to the trans-Golgi network, where final virion envelopment occurs. Studies in which VZV gM or its partner gN were disrupted suggest that the gM/gN complex plays an important role in cell-to-cell spread. Here, we summarize the biological features of VZV gM, including our recent findings on its characterization and function.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsReferences
Baines JD, Roizman B (1991) J Virol 65:938–944
Baines JD, Wills E, Jacob RJ, Pennington J, Roizman B (2007) J Virol 81:800–812
Cohen JI, Straus SE, Arvin AM (2006) Varicella-Zoster virus, replication, pathogenesis, and management. In: Knipe DM, Howley PM, Griffin DE, Lamb RA, Martin MA, Roizman B, Straus SE (eds) Fields virology. Lippincott Williams & Wilkins, Philadelphia, pp 2774–2818
Crump CM, Bruun B, Bell S, Pomeranz LE, Minson T, Browne HM (2004) J Gen Virol 85:3517–3527
Dijkstra JM, Visser N, Mettenleiter TC, Klupp BG (1996) J Virol 70:5684–5688
Dijkstra JM, Brack A, Jons A, Klupp BG, Mettenleiter TC (1998) J Gen Virol 79(Pt 4):851–854
Gershon AA, Sherman DL, Zhu Z, Gabel CA, Ambron RT, Gershon MD (1994) J Virol 68:6372–6390
Hobom U, Brune W, Messerle M, Hahn G, Koszinowski UH (2000) J Virol 74:7720–7729
Jons A, Dijkstra JM, Mettenleiter TC (1998) J Virol 72:550–557
Klupp BG, Nixdorf R, Mettenleiter TC (2000) J Virol 74:6760–6768
Koyano S, Mar EC, Stamey FR, Inoue N (2003) J Gen Virol 84:1485–1491
Krzyzaniak M, Mach M, Britt WJ (2007) J Virol 81:10316–10328
Lake CM, Molesworth SJ, Hutt-Fletcher LM (1998) J Virol 72:5559–5564
Liang X, Chow B, Raggo C, Babiuk LA (1996) J Virol 70:1448–1454
Mach M, Kropff B, Dal Monte P, Britt W (2000) J Virol 74:11881–11892
Mach M, Kropff B, Kryzaniak M, Britt W (2005) J Virol 79:2160–2170
Mach M, Osinski K, Kropff B, Schloetzer-Schrehardt U, Krzyzaniak M, Britt W (2007) J Virol 81:5212–5224
Mettenleiter TC (2004) Virus Res 106:167–180
Nagaike K, Mori Y, Gomi Y, Yoshii H, Takahashi M, Wagner M, Koszinowski U, Yamanishi K (2004) Vaccine 22:4069–4074
Osterrieder N, Neubauer A, Brandmuller C, Braun B, Kaaden OR, Baines JD (1996) J Virol 70:4110–4115
Ross J, Williams M, Cohen JI (1997) Virology 234:186–195
Shimamura M, Mach M, Britt WJ (2006) J Virol 80:4591–4600
Spear PG, Longnecker R (2003) J Virol 77:10179–10185
Tischer BK, Schumacher D, Messerle M, Wagner M, Osterrieder N (2002) J Gen Virol 83:997–1003
Wu SX, Zhu XP, Letchworth GJ (1998) J Virol 72:3029–3036
Yamagishi Y, Sadaoka T, Yoshii H, Somboonthum P, Imazawa T, Nagaike K, Ozono K, Yamanishi K, Mori Y (2008) J Virol 82:795–804
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2010 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Mori, Y., Sadaoka, T. (2010). Varicella-Zoster Virus Glycoprotein M. In: Abendroth, A., Arvin, A., Moffat, J. (eds) Varicella-zoster Virus. Current Topics in Microbiology and Immunology, vol 342. Springer, Berlin, Heidelberg. https://doi.org/10.1007/82_2010_30
Download citation
DOI: https://doi.org/10.1007/82_2010_30
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-12727-4
Online ISBN: 978-3-642-12728-1
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)