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The Chemokine System: A Possible Therapeutic Target in Acute Graft Versus Host Disease

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Book cover The Chemokine System in Experimental and Clinical Hematology

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 341))

Abstract

Allogeneic hematopoetic stem cell transplantation often presents the only chance for cure in a number of malignant and nonmalignant hematologic diseases. However, its beneficial effects are counterweighed by the development of potentially lethal complications, most importantly the development of acute and chronic graft-vs.-host disease (GVHD). Alloantigen-reactive immune responses mediate injury and destruction of GVHD target organs, including the gastrointestinal tract, the liver, the skin, and the lung. Donor leukocyte infiltration into the respective tissues is orchestrated by interactions between chemokines and chemokine receptors, which will be reviewed using a basic science – clinical comparative approach.

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  1. Feist-Weiller Cancer Center, Louisiana State University Health Sciences Center – Shreveport, 1501 Kings Highway, 71130, Shreveport, LA, USA

    Nicolai A. Kittan & Gerhard C. Hildebrandt

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  1. Nicolai A. Kittan
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  2. Gerhard C. Hildebrandt
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  1. Dept. Medicine, Div. Infectious Diseases, Haukeland University Hospital, Bergen, 5021, Norway

    Oystein Bruserud

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Kittan, N.A., Hildebrandt, G.C. (2010). The Chemokine System: A Possible Therapeutic Target in Acute Graft Versus Host Disease. In: Bruserud, O. (eds) The Chemokine System in Experimental and Clinical Hematology. Current Topics in Microbiology and Immunology, vol 341. Springer, Berlin, Heidelberg. https://doi.org/10.1007/82_2010_23

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