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Varicella-zoster Virus pp 323–340Cite as

Varicella-Zoster Virus Vaccine: Molecular Genetics

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Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 342))

Abstract

The genetic differences that potentially account for the attenuation of the Oka vaccine VZV preparation are more clearly defined than for perhaps any other vaccine in current use. This is due in large part to the small number of differences between the vaccine and the parental strain from which it was derived, and to the high level of genomic conservation that characterizes VZV. This information has been used with great success to develop methods that discriminate vaccine from wild-type strains, to begin determining which specific vaccine markers contribute to the attenuated phenotype, to improve evaluations of vaccine efficacy and safety, and to observe the behavior of the live, attenuated preparation as it becomes more prevalent through widespread immunization.

The findings and conclusions in this report are those of the author and do not necessarily represent the views of the funding agency.

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Authors and Affiliations

  1. Herpesvirus Team and National VZV Laboratory, MMRHLB, Centers for Disease Control and Prevention, 1600 Clifton Rd/Bldg 18/Rm 6-134/ MS G-18, Atlanta, GA, 30333, USA

    D. Scott Schmid

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  1. D. Scott Schmid
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Correspondence to D. Scott Schmid .

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Editors and Affiliations

  1. Department of Infectious Diseases and Im, Head, VZV Research Laboratory, University of Sydney, Room 601 Blackburn Building D06, Sydney, 2006, New South Wales, Australia

    Allison Abendroth

  2. School of Medicine, Dept. Microbiology & Immunology, Stanford University, Pasteur Drive 300, Stanford, 94305-5124, California, USA

    Ann M. Arvin

  3. 2215 Weiskotten Hall, Upstate Medical University, East Adams Street 750, Syracuse, 13210, New York, USA

    Jennifer F. Moffat

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Schmid, D.S. (2010). Varicella-Zoster Virus Vaccine: Molecular Genetics. In: Abendroth, A., Arvin, A., Moffat, J. (eds) Varicella-zoster Virus. Current Topics in Microbiology and Immunology, vol 342. Springer, Berlin, Heidelberg. https://doi.org/10.1007/82_2010_14

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