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NF-kB in Health and Disease pp 25–60Cite as

NF-κB/Rel Proteins and the Humoral Immune Responses of Drosophila melanogaster

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Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 349))

Abstract

Nuclear Factor-κB (NF-κB)/Rel transcription factors form an integral part of innate immune defenses and are conserved throughout the animal kingdom. Studying the function, mechanism of activation and regulation of these factors is crucial for understanding host responses to microbial infections. The fruit fly Drosophila melanogaster has proved to be a valuable model system to study these evolutionarily conserved NF-κB mediated immune responses. Drosophila combats pathogens through humoral and cellular immune responses. These humoral responses are well characterized and are marked by the robust production of a battery of anti-microbial peptides. Two NF-κB signaling pathways, the Toll and the IMD pathways, are responsible for the induction of these antimicrobial peptides. Signal transduction in these pathways is strikingly similar to that in mammalian TLR pathways. In this chapter, we discuss in detail the molecular mechanisms of microbial recognition, signal transduction and NF-κB regulation, in both the Toll and the IMD pathways. Similarities and differences relative to their mammalian counterparts are discussed, and recent advances in our understanding of the intricate regulatory networks in these NF-κB signaling pathways are also highlighted.

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Authors and Affiliations

  1. Division of Infectious Diseases, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, 01605, USA

    Sandhya Ganesan, Kamna Aggarwal & Neal Silverman

  2. Program of Developmental Immunology, Department of Pediatrics, Massachusetts General Hospital/Harvard Medical School, Boston, MA, 02114, USA

    Nicholas Paquette

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  1. Sandhya Ganesan
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  2. Kamna Aggarwal
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  3. Nicholas Paquette
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  4. Neal Silverman
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Correspondence to Neal Silverman .

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  1. School of Medicine, Dept. Pharmacology, University of California, San Diego, Gilman Dr. 9500, La Jolla, 92093-0636, California, USA

    Michael Karin

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Ganesan, S., Aggarwal, K., Paquette, N., Silverman, N. (2010). NF-κB/Rel Proteins and the Humoral Immune Responses of Drosophila melanogaster . In: Karin, M. (eds) NF-kB in Health and Disease. Current Topics in Microbiology and Immunology, vol 349. Springer, Berlin, Heidelberg. https://doi.org/10.1007/82_2010_107

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