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NF-kB in Health and Disease pp 61–72Cite as

Specialized Chromatin Patterns in the Control of Inflammatory Gene Expression

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Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 349))

Abstract

Inflammatory responses to microbial and non-microbial stimuli involve coordinate changes in the expression of hundreds of genes. The inflammatory gene expression programs display two important features: first, alternative stimuli affect both a large set of common genes and a variable number of stimulus-specific genes. Second, different genes are activated with different kinetics over several hours after the initial stimulus. Mechanistically, these features reflect the interplay between two main groups of determinants: the combinatorial control of transcription by multiple transcription factors, with NF-κB and the IRFs playing a central and essential role in the induction of a large fraction of inflammatory genes; and the presence of well-defined, in part cell-type specific, patterns of chromatin organization at cis-regulatory regions of inflammatory genes. Recent advancements in this field are providing paradigms of general value explaining how inducible responses to environmental stimuli are controlled.

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Acknowledgments

Research in GN lab is supported by the EC FP6 programme (Marie Curie excellence grant Trans-Tar), the FP7 programme (integrated project Model-In) and the Italian Association for Research on Cancer (A.I.R.C.).

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Authors and Affiliations

  1. Department of Experimental Oncology, European Institute of Oncology (IEO), IFOM-IEO Campus, Via Adamello 16, 20139, Milan, Italy

    Gioacchino Natoli

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  1. Gioacchino Natoli
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Correspondence to Gioacchino Natoli .

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Editors and Affiliations

  1. School of Medicine, Dept. Pharmacology, University of California, San Diego, Gilman Dr. 9500, La Jolla, 92093-0636, California, USA

    Michael Karin

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© 2010 Springer-Verlag Berlin Heidelberg

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Natoli, G. (2010). Specialized Chromatin Patterns in the Control of Inflammatory Gene Expression. In: Karin, M. (eds) NF-kB in Health and Disease. Current Topics in Microbiology and Immunology, vol 349. Springer, Berlin, Heidelberg. https://doi.org/10.1007/82_2010_106

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