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Discriminative Stimulus Properties of Opioid Ligands: Progress and Future Directions

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The Behavioral Neuroscience of Drug Discrimination

Part of the book series: Current Topics in Behavioral Neurosciences ((CTBN,volume 39))

Abstract

Opioid receptors (MOP-r, KOP-r, DOP-r, as well as NOP-r) and their endogenous neuropeptide agonist systems are involved in diverse neurobiological and behavioral functions, in health and disease. These functions include pain and analgesia, addictions, and psychiatric diseases (e.g., depression-, anxiety-like, and stress-related disorders). Drug discrimination assays have been used to characterize the behavioral pharmacology of ligands with affinity at MOP-r, KOP-r, or DOP-r (and to a lesser extent NOP-r). Therefore, drug discrimination studies with opioid ligands have an important continuing role in translational investigations of diseases that are affected by these neurobiological targets and their pharmacotherapy.

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Acknowledgements

Experimental work by the authors was supported by the NIH-NIDA grants DA011113 and DA017369 (ERB), and DA05130, which are gratefully acknowledged.

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Authors and Affiliations

  1. Laboratory on the Biology of Addictive Diseases, The Rockefeller University, 1230 York Avenue, Box 171, New York, NY, 10065, USA

    Eduardo R. Butelman & Mary Jeanne Kreek

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  1. Eduardo R. Butelman
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  2. Mary Jeanne Kreek
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Correspondence to Eduardo R. Butelman .

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Editors and Affiliations

  1. Department of Psychology, Virginia Commonwealth University, Richmond, VA, USA

    Joseph H. Porter

  2. Department of Psychological Science, Northern Michigan University, Marquette, MI, USA

    Adam J. Prus

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Butelman, E.R., Kreek, M.J. (2016). Discriminative Stimulus Properties of Opioid Ligands: Progress and Future Directions. In: Porter, J.H., Prus, A.J. (eds) The Behavioral Neuroscience of Drug Discrimination. Current Topics in Behavioral Neurosciences, vol 39. Springer, Cham. https://doi.org/10.1007/7854_2016_9

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