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Basal Forebrain Cholinergic System and Memory

  • Chapter
Behavioral Neuroscience of Learning and Memory

Part of the book series: Current Topics in Behavioral Neurosciences ((CTBN,volume 37))

Abstract

Basal forebrain cholinergic neurons constitute a way station for many ascending and descending pathways. These cholinergic neurons have a role in eliciting cortical activation and arousal. It is well established that they are mainly involved in cognitive processes requiring increased levels of arousal, attentive states and/or cortical activation with desynchronized activity in the EEG. These cholinergic neurons are modulated by several afferents of different neurotransmitter systems. Of particular importance within the cortical targets of basal forebrain neurons is the hippocampal cortex. The septohippocampal pathway is a bidirectional pathway constituting the main septal efferent system, which is widely known to be implicated in every memory process investigated. The present work aims to review the main neurotransmitter systems involved in modulating cognitive processes related to learning and memory through modulation of basal forebrain neurons.

Blake and Boccia—Both authors contributed equally.

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Authors and Affiliations

  1. Facultad de Medicina UBA, CONICET. Paraguay, Instituto de Fisiología y Biofísica Bernardo Houssay, 7th Floor (C1121ABG), 2155, Buenos Aires, Argentina

    M. G Blake

  2. Laboratorio de Neurofarmacología de la Memoria, Cátedra de Farmacología, Facultad de Farmacia y Bioquímica, UBA. Junín, 5th Floor (C1113AAD), 956, Buenos Aires, Argentina

    M. M Boccia

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  1. University of California San Diego School of Medicine, La Jolla, USA

    Robert E. Clark

  2. VA Medical Center, San Diego, USA

    Robert E. Clark

  3. Medical Research Institute, Ninewells Hospital and Medical School, Dundee, UK

    Stephen J. Martin

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Blake, M.G., Boccia, M.M. (2016). Basal Forebrain Cholinergic System and Memory. In: Clark, R.E., Martin, S. (eds) Behavioral Neuroscience of Learning and Memory. Current Topics in Behavioral Neurosciences, vol 37. Springer, Cham. https://doi.org/10.1007/7854_2016_467

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