Neural Activity Patterns Underlying Spatial Coding in the Hippocampus

  • Marielena Sosa
  • Anna K. Gillespie
  • Loren M. Frank
Chapter
Part of the Current Topics in Behavioral Neurosciences book series (CTBN, volume 37)

Abstract

The hippocampus is well known as a central site for memory processing—critical for storing and later retrieving the experiences events of daily life so they can be used to shape future behavior. Much of what we know about the physiology underlying hippocampal function comes from spatial navigation studies in rodents, which have allowed great strides in understanding how the hippocampus represents experience at the cellular level. However, it remains a challenge to reconcile our knowledge of spatial encoding in the hippocampus with its demonstrated role in memory-dependent tasks in both humans and other animals. Moreover, our understanding of how networks of neurons coordinate their activity within and across hippocampal subregions to enable the encoding, consolidation, and retrieval of memories is incomplete. In this chapter, we explore how information may be represented at the cellular level and processed via coordinated patterns of activity throughout the subregions of the hippocampal network.

Keywords

hippocampus learning memory oscillations LFP network activity spatial coding place cells theta gamma sharp-wave ripples 

Notes

Acknowledgements

We wish to thank members of the Frank lab for their careful reviews and constructive comments on this book chapter. In particular, we thank Kenny Kay for the hippocampal recording data displayed in Fig. 2.

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Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  • Marielena Sosa
    • 1
  • Anna K. Gillespie
    • 2
  • Loren M. Frank
    • 1
    • 2
  1. 1.Kavli Institute for Fundamental Neuroscience and Department of PhysiologyUniversity of CaliforniaSan FranciscoUSA
  2. 2.Howard Hughes Medical InstituteMarylandUSA

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