What Versus Where: Non-spatial Aspects of Memory Representation by the Hippocampus
Since the discovery of place cells and other findings indicating strong involvement of the hippocampus in spatial information processing, there has been continued controversy about the extent to which the hippocampus also processes non-spatial aspects of experience. In recent years, many experiments studying the effects of hippocampal damage and characterizing hippocampal neural activity in animals and humans have revealed a clear and specific role of the hippocampus in the processing of non-spatial information. Here this evidence is reviewed in support of the notion that the hippocampus organizes the contents of memory in space, in time, and in networks of related memories.
KeywordsNon-spatial memory Hippocampus Neural activity Relational memory Episodic memory
NIMH MH094263, MH51570; MH52090, MH095297; ONR MURI N00014-0-1-0936.
- Deadwyler SA, Bunn T, Hampson RE (1995) Hippocampal ensemble activity during spatial delayed-nonmatch-to-sample performance in rats. J Neurosci 16:354–372Google Scholar
- Modi MN, Dhawale AK, Bhalla US (2014) CA1 cell activity sequences emerge after reorganization of network correlation structure during associative learning. eLife 3:e01982Google Scholar
- Muzzio IA, Levita L, Kulkarni J, Monaco J, Kentros C, Stead M, Abbott LF, Kandel ER (2009) Attention enhances the retrieval and stability of visuospatial and olfactory representations in the dorsal hippocampus. PLoS Biol 7(6):e1000140. doi: 10.1371/journal.pbio.1000140CrossRefPubMedPubMedCentralGoogle Scholar
- O’Keefe J, Nadel L (1978) The hippocampus as a cognitive map. Oxford University Press, New YorkGoogle Scholar