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Sleep, Neuronal Plasticity and Brain Function pp 433–458Cite as

Sleep and Plasticity in Schizophrenia

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Part of the book series: Current Topics in Behavioral Neurosciences ((CTBN,volume 25))

Abstract

Schizophrenia is a devastating mental illness with a worldwide prevalence of approximately 1 %. Although the clinical features of the disorder were described over one hundred years ago, its neurobiology is still largely elusive despite several decades of research. Schizophrenia is associated with marked sleep disturbances and memory impairment. Above and beyond altered sleep architecture, sleep rhythms including slow waves and spindles are disrupted in schizophrenia. In the healthy brain, these rhythms reflect and participate in plastic processes during sleep. This chapter discusses evidence that schizophrenia patients exhibit dysfunction of sleep-mediated plasticity on a behavioral, cellular, and molecular level and offers suggestions on how the study of sleeping brain activity can shed light on the pathophysiological mechanisms of the disorder.

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Authors and Affiliations

  1. Department of Psychiatry, Neuroscience Training Program, University of Wisconsin, Madison, WI, USA

    Kate E. Sprecher

  2. Department of Psychiatry, University of Wisconsin, 6001 Research Park Blvd, Madison, WI, 53719, USA

    Kate E. Sprecher, Fabio Ferrarelli & Ruth M. Benca

  3. Wisconsin Center for Sleep Medicine and Research, University of Wisconsin, 6001 Research Park Blvd, Madison, WI, 53719, USA

    Ruth M. Benca

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  1. Kate E. Sprecher
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  2. Fabio Ferrarelli
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  3. Ruth M. Benca
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Correspondence to Ruth M. Benca .

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  1. Center for Behavior and Neurosciences, University of Groningen, Groningen, The Netherlands

    Peter Meerlo

  2. Department of Psychiatry, University of Wisconsin-Madison, Madison, Wisconsin, USA

    Ruth M. Benca

  3. Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania, USA

    Ted Abel

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Sprecher, K.E., Ferrarelli, F., Benca, R.M. (2015). Sleep and Plasticity in Schizophrenia. In: Meerlo, P., Benca, R., Abel, T. (eds) Sleep, Neuronal Plasticity and Brain Function. Current Topics in Behavioral Neurosciences, vol 25. Springer, Berlin, Heidelberg. https://doi.org/10.1007/7854_2014_366

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