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Sleep Deprivation and Gene Expression

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Sleep, Neuronal Plasticity and Brain Function

Part of the book series: Current Topics in Behavioral Neurosciences ((CTBN,volume 25))

Abstract

Sleep occurs in a wide range of animal species as a vital process for the maintenance of homeostasis, metabolic restoration, physiological regulation, and adaptive cognitive functions in the central nervous system. Long-term perturbations induced by the lack of sleep are mostly mediated by changes at the level of transcription and translation. This chapter reviews studies in humans, rodents, and flies to address the various ways by which sleep deprivation affects gene expression in the nervous system, with a focus on genes related to neuronal plasticity, brain function, and cognition. However, the effects of sleep deprivation on gene expression and the functional consequences of sleep loss are clearly not restricted to the cognitive domain but may include increased inflammation, expression of stress-related genes, general impairment of protein translation, metabolic imbalance, and thermal deregulation.

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Acknowledgments

Support obtained from the Pew Latin American Fellows Program in the Biomedical Sciences, Ministério da Ciência e Tecnologia e Inovação (MCTI), CNPq Universal Grant 481351/2011-6, FAPESP Neuromat (2013/ 07699-0), and a graduate fellowship from Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) to A.C.S. We thank D. Koshiyama for library support.

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  1. Instituto do Cérebro, Universidade Federal do Rio Grande do Norte (UFRN), Av. Nascimento de Castro 2155, Natal-RN, Brazil

    Annie da Costa Souza & Sidarta Ribeiro

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  1. Annie da Costa Souza
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  2. Sidarta Ribeiro
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Correspondence to Sidarta Ribeiro .

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  1. Center for Behavior and Neurosciences, University of Groningen, Groningen, The Netherlands

    Peter Meerlo

  2. Department of Psychiatry, University of Wisconsin-Madison, Madison, Wisconsin, USA

    Ruth M. Benca

  3. Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania, USA

    Ted Abel

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da Costa Souza, A., Ribeiro, S. (2015). Sleep Deprivation and Gene Expression. In: Meerlo, P., Benca, R., Abel, T. (eds) Sleep, Neuronal Plasticity and Brain Function. Current Topics in Behavioral Neurosciences, vol 25. Springer, Berlin, Heidelberg. https://doi.org/10.1007/7854_2014_360

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