Abstract
Stress has been shown to have marked and divergent effects on learning and memory which involves specific brain regions, such as spatial and declarative memory involving the hippocampus, memory of emotional arousing experiences and fear involving the amygdala, and executive functions and fear extinction involving the prefrontal cortex or the PFC. Response to stress involves a coordinated activation of a constellation of physiological systems including the activation of the hypothalamic-pituitary-adrenal (HPA) axis and other modulatory neurotransmitters and signaling systems. This paper presents a concise review of the effects of stress and glucocorticoids on the glutamatergic and monoaminergic (including noradrenergic, dopaminergic, and serotonergic systems) neurotransmitter systems as well as endocannabinoid signaling. Because of the breadth of the scope of this topic, the review is limited to the effects of stress on these brain systems on the prefrontal cortex, and where relevant, the hippocampus and the amygdala.
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References
Andolina D, Maran D, Valzania A, Conversi D, Puglisi-Allegra S (2013) Prefrontal/amygdalar system determines stress coping behavior through 5-HT/GABA connection. Neuropsychopharmacol: Off Publ Am Coll Neuropsychopharmacol 38(10):2057–2067
Asan E, Steinke M, Lesch KP (2013) Serotonergic innervation of the amygdala: targets, receptors, and implications for stress and anxiety. Histochem Cell Biol 139(6):785–813
Aso E, Ozaita A, Valdizan EM, Ledent C, Pazos A, Maldonado R, Valverde O (2008) BDNF impairment in the hippocampus is related to enhanced despair behavior in CB1 knockout mice. J Neurochem 105(2):565–572
Atwood BK, Mackie K (2010) CB2: a cannabinoid receptor with an identity crisis. Br J Pharmacol 160(3):467–479
Barik J, Marti F, Morel C, Fernandez SP, Lanteri C, Godeheu G, Tassin JP, Mombereau C, Faure P, Tronche F (2013) Chronic stress triggers social aversion via glucocorticoid receptor in dopaminoceptive neurons. Science (New York, N.Y.) 339(6117):332–335
Barna I, Zelena D, Arszovszki AC, Ledent C (2004) The role of endogenous cannabinoids in the hypothalamo-pituitary-adrenal axis regulation: in vivo and in vitro studies in CB1 receptor knockout mice. Life Sci 75(24):2959–2970
Baumeister D, Lightman SL, Pariante CM (2014) The interface of stress and the HPA axis in behavioural phenotypes of mental illness. In: Current topics in behavioral neurosciences. doi:10.1007/7854_2014_304
Bellocchio L, Cervino C, Pasquali R, Pagotto U (2008) The endocannabinoid system and energy metabolism. J Neuroendocrinol 20(6):850–857
Berridge CW, Waterhouse BD (2003) The locus coeruleus-noradrenergic system: modulation of behavioral state and state-dependent cognitive processes. Brain Res Brain Res Rev 42(1):33–84
Beyer CE, Cremers TI (2008) Do selective serotonin reuptake inhibitors acutely increase frontal cortex levels of serotonin? Eur J Pharmacol 580(3):350–354
Beylin AV, Shors TJ (2003) Glucocorticoids are necessary for enhancing the acquisition of associative memories after acute stressful experience. Horm Behav 43(1):124–131
Bubar MJ, Cunningham KA (2006) Serotonin 5-HT2A and 5-HT2C receptors as potential targets for modulation of psychostimulant use and dependence. Curr Top Med Chem 6(18):1971–1985
Burghardt PR, Love TM, Stohler CS, Hodgkinson C, Shen PH, Enoch MA, Goldman D, Zubieta JK (2012) Leptin regulates dopamine responses to sustained stress in humans. J Neurosci: Off J Soc Neurosci 32(44):15369–15376
Burke AR, Forster GL, Novick AM, Roberts CL, Watt MJ (2013) Effects of adolescent social defeat on adult amphetamine-induced locomotion and corticoaccumbal dopamine release in male rats. Neuropharmacology 67:359–369
Burke AR, Renner KJ, Forster GL, Watt MJ (2010) Adolescent social defeat alters neural, endocrine and behavioral responses to amphetamine in adult male rats. Brain Res 1352:147–156
Burke AR, Watt MJ, Forster GL (2011) Adolescent social defeat increases adult amphetamine conditioned place preference and alters D2 dopamine receptor expression. Neuroscience 197:269–279
Butts KA, Weinberg J, Young AH, Phillips AG (2011) Glucocorticoid receptors in the prefrontal cortex regulate stress-evoked dopamine efflux and aspects of executive function. Proc Natl Acad Sci U S A 108(45):18459–18464
Carlson G, Wang Y, Alger BE (2002) Endocannabinoids facilitate the induction of LTP in the hippocampus. Nat Neurosci 5(8):723–724
Cerqueira JJ, Mailliet F, Almeida OF, Jay TM, Sousa N (2007) The prefrontal cortex as a key target of the maladaptive response to stress. J Neurosci: Off J Soc Neurosci 27(11):2781–2787
Chang MS, Sved AF, Zigmond MJ, Austin MC (2000) Increased transcription of the tyrosine hydroxylase gene in individual locus coeruleus neurons following footshock stress. Neuroscience 101(1):131–139
Corchero J, Romero J, Berrendero F, Fernandez-Ruiz J, Ramos JA, Fuentes JA, Manzanares J (1999) Time-dependent differences of repeated administration with Delta9-tetrahydrocannabinol in proenkephalin and cannabinoid receptor gene expression and G-protein activation by mu-opioid and CB1-cannabinoid receptors in the caudate-putamen. Brain Res Mol Brain Res 67(1):148–157
Deutsch DG, Ueda N, Yamamoto S (2002) The fatty acid amide hydrolase (FAAH). Prostaglandins Leukot Essent Fatty Acids 66(2–3):201–210
Devane WA, Hanus L, Breuer A, Pertwee RG, Stevenson LA, Griffin G, Gibson D, Mandelbaum A, Etinger A, Mechoulam R (1992) Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science (New York, N.Y.) 258(5090):1946–1949
Diamond DM, Campbell AM, Park CR, Halonen J, Zoladz PR (2007) The temporal dynamics model of emotional memory processing: a synthesis on the neurobiological basis of stress-induced amnesia, flashbulb and traumatic memories, and the Yerkes-Dodson law. Neural Plast 2007:60803
Dinh TP, Freund TF, Piomelli D (2002) A role for monoglyceride lipase in 2-arachidonoylglycerol inactivation. Chem Phys Lipids 121(1–2):149–158
Diorio D, Viau V, Meaney MJ (1993) The role of the medial prefrontal cortex (cingulate gyrus) in the regulation of hypothalamic-pituitary-adrenal responses to stress. J Neurosci: Off J Soc Neurosci 13(9):3839–3847
Doppler W (1994) Regulation of gene expression by prolactin. Rev Physiol Biochem Pharmacol 124:93–130
Doyon WM, Thomas AM, Ostroumov A, Dong Y, Dani JA (2013) Potential substrates for nicotine and alcohol interactions: a focus on the mesocorticolimbic dopamine system. Biochem Pharmacol 86(8):1181–1193
Ebner K, Bosch OJ, Kromer SA, Singewald N, Neumann ID (2005) Release of oxytocin in the rat central amygdala modulates stress-coping behavior and the release of excitatory amino acids. Neuropsychopharmacol: Off Publ Am Coll Neuropsychopharmacol 30(2):223–230
Ebner K, Singewald GM, Whittle N, Ferraguti F, Singewald N (2008) Neurokinin 1 receptor antagonism promotes active stress coping via enhanced septal 5-HT transmission. Neuropsychopharmacol: Off Publ Am Coll Neuropsychopharmacol 33(8):1929–1941
Erecinska M, Silver IA (1990) Metabolism and role of glutamate in mammalian brain. Prog Neurobiol 35(4):245–296
Evanson NK, Tasker JG, Hill MN, Hillard CJ, Herman JP (2010) Fast feedback inhibition of the HPA axis by glucocorticoids is mediated by endocannabinoid signaling. Endocrinology 151(10):4811–4819
Furay AR, Bruestle AE, Herman JP (2008) The role of the forebrain glucocorticoid receptor in acute and chronic stress. Endocrinology 149(11):5482–5490
Ganon-Elazar E, Akirav I (2009) Cannabinoid receptor activation in the basolateral amygdala blocks the effects of stress on the conditioning and extinction of inhibitory avoidance. J Neurosci: Off J Soc Neurosci 29(36):11078–11088
Garrett JE, Wellman CL (2009) Chronic stress effects on dendritic morphology in medial prefrontal cortex: sex differences and estrogen dependence. Neuroscience 162(1):195–207
Gasser PJ, Lowry CA, Orchinik M (2006) Corticosterone-sensitive monoamine transport in the rat dorsomedial hypothalamus: potential role for organic cation transporter 3 in stress-induced modulation of monoaminergic neurotransmission. J Neurosci: Off J Soc Neurosci 26(34):8758–8766
Gasser PJ, Orchinik M, Raju I, Lowry CA (2009) Distribution of organic cation transporter 3, a corticosterone-sensitive monoamine transporter, in the rat brain. J Comp Neurol 512(4):529–555
Gorzalka BB, Hill MN (2011) Putative role of endocannabinoid signaling in the etiology of depression and actions of antidepressants. Prog Neuropsychopharmacol Biol Psychiatry 35(7):1575–1585
Gorzalka BB, Hill MN, Hillard CJ (2008) Regulation of endocannabinoid signaling by stress: implications for stress-related affective disorders. Neurosci Biobehav Rev 32(6):1152–1160
Grace AA, Floresco SB, Goto Y, Lodge DJ (2007) Regulation of firing of dopaminergic neurons and control of goal-directed behaviors. Trends Neurosci 30(5):220–227
Guptan P, Dhingra A, Panicker MM (1997) Multiple transcripts encode the 5-HT1F receptor in rodent brain. Neuroreport 8(15):3317–3321
Hale MW, Shekhar A, Lowry CA (2012) Stress-related serotonergic systems: implications for symptomatology of anxiety and affective disorders. Cell Mol Neurobiol 32(5):695–708
Haller J, Varga B, Ledent C, Barna I, Freund TF (2004) Context-dependent effects of CB1 cannabinoid gene disruption on anxiety-like and social behaviour in mice. Eur J Neurosci 19(7):1906–1912
Harro J, Oreland L, Vasar E, Bradwejn J (1995) Impaired exploratory behaviour after DSP-4 treatment in rats: implications for the increased anxiety after noradrenergic denervation. Eur Neuropsychopharmacol: J Eur Coll Neuropsychopharmacol 5(4):447–455
Herkenham M, Lynn AB, Johnson MR, Melvin LS, de Costa BR, Rice KC (1991) Characterization and localization of cannabinoid receptors in rat brain: a quantitative in vitro autoradiographic study. J Neurosci: Off J Soc Neurosci 11(2):563–583
Herman JP, Mueller NK (2006) Role of the ventral subiculum in stress integration. Behav Brain Res 174(2):215–224
Hill MN, Hillard CJ, MCEwen BS (2011) Alterations in corticolimbic dendritic morphology and emotional behavior in cannabinoid CB1 receptor-deficient mice parallel the effects of chronic stress. Cereb cortex (New York, N.Y.: 1991) 21(9):2056–2064
Hill MN, Hunter RG, McEwen BS (2009) Chronic stress differentially regulates cannabinoid CB1 receptor binding in distinct hippocampal subfields. Eur J Pharmacol 614(1–3):66–69
Hill MN, Patel S, Campolongo P, Tasker JG, Wotjak CT, Bains JS (2010) Functional interactions between stress and the endocannabinoid system: from synaptic signaling to behavioral output. J Neurosci: Off J Soc Neurosci 30(45):14980–14986
Hill MN, Tasker JG (2012) Endocannabinoid signaling, glucocorticoid-mediated negative feedback, and regulation of the hypothalamic-pituitary-adrenal axis. Neuroscience 204:5–16
Itoi K, Jiang YQ, Iwasaki Y, Watson SJ (2004) Regulatory mechanisms of corticotropin-releasing hormone and vasopressin gene expression in the hypothalamus. J Neuroendocrinol 16(4):348–355
Itoi K, Sugimoto N (2010) The brainstem noradrenergic systems in stress, anxiety and depression. J Neuroendocrinol 22(5):355–361
Jacobs BL, Fornal CA (1999) Activity of serotonergic neurons in behaving animals. Neuropsychopharmacol: Off Publ Am Coll Neuropsychopharmacol 21(2 Suppl):9S–15S
Jaferi A, Bhatnagar S (2006) Corticosterone can act at the posterior paraventricular thalamus to inhibit hypothalamic-pituitary-adrenal activity in animals that habituate to repeated stress. Endocrinology 147(10):4917–4930
Jaferi A, Nowak N, Bhatnagar S (2003) Negative feedback functions in chronically stressed rats: role of the posterior paraventricular thalamus. Physiol Behav 78(3):365–373
Jedema HP, Grace AA (2004) Corticotropin-releasing hormone directly activates noradrenergic neurons of the locus ceruleus recorded in vitro. J Neurosci: Off J Soc Neurosci 24(43):9703–9713
Joels M, Baram TZ (2009) The neuro-symphony of stress. Nat Rev Neurosci 10(6):459–466
Karst H, Berger S, Turiault M, Tronche F, Schutz G, Joels M (2005) Mineralocorticoid receptors are indispensable for nongenomic modulation of hippocampal glutamate transmission by corticosterone. Proc Natl Acad Sci U S A 102(52):19204–19207
Kawahara H, Kawahara Y, Westerink BH (2000) The role of afferents to the locus coeruleus in the handling stress-induced increase in the release of noradrenaline in the medial prefrontal cortex: a dual-probe microdialysis study in the rat brain. Eur J Pharmacol 387(3):279–286
Kim CH, Lee J, Lee JY, Roche KW (2008) Metabotropic glutamate receptors: phosphorylation and receptor signaling. J Neurosci Res 86(1):1–10
Klink R, Robichaud M, Debonnel G (2002) Gender and gonadal status modulation of dorsal raphe nucleus serotonergic neurons. Part II. Regulatory mechanisms. Neuropharmacology 43(7):1129–1138
Lang T, Jahn R (2008) Core proteins of the secretory machinery. Handb Exp Pharmacol 184:107–127
Lapiz MD, Mateo Y, Durkin S, Parker T, Marsden CA (2001) Effects of central noradrenaline depletion by the selective neurotoxin DSP-4 on the behaviour of the isolated rat in the elevated plus maze and water maze. Psychopharmacology 155(3):251–259
Liston C, Miller MM, Goldwater DS, Radley JJ, Rocher AB, Hof PR, Morrison JH, McEwen BS (2006) Stress-induced alterations in prefrontal cortical dendritic morphology predict selective impairments in perceptual attentional set-shifting. J Neurosci: Off J Soc Neurosci 26(30):7870–7874
Lowry CA, Hale MW, Evans AK, Heerkens J, Staub DR, Gasser PJ, Shekhar A (2008) Serotonergic systems, anxiety, and affective disorder: focus on the dorsomedial part of the dorsal raphe nucleus. Ann N Y Acad Sci 1148:86–94
Lowther S, de Paermentier F, Crompton MR, Horton RW (1992) The distribution of 5-HT1D and 5-HT1E binding sites in human brain. Eur J Pharmacol 222(1):137–142
Lupien SJ (2009) Brains under stress. Can J Psychiatry Revue Can Psychiatr 54(1):4–5
Makino S, Smith MA, Gold PW (2002) Regulatory role of glucocorticoids and glucocorticoid receptor mRNA levels on tyrosine hydroxylase gene expression in the locus coeruleus during repeated immobilization stress. Brain Res 943(2):216–223
Marazziti D, Baroni S, Borsini F, Picchetti M, Vatteroni E, Falaschi V, Catena-Dell’Osso M (2013) Serotonin receptors of type 6 (5-HT6): from neuroscience to clinical pharmacology. Curr Med Chem 20(3):371–377
Marchetti E, Dumuis A, Bockaert J, Soumireu-Mourat B, Roman FS (2000) Differential modulation of the 5-HT(4) receptor agonists and antagonist on rat learning and memory. Neuropharmacology 39(11):2017–2027
Marquez C, Poirier GL, Cordero MI, Larsen MH, Groner A, Marquis J, Magistretti PJ, Trono D, Sandi C (2013) Peripuberty stress leads to abnormal aggression, altered amygdala and orbitofrontal reactivity and increased prefrontal MAOA gene expression. Transl Psychiatry 3:e216
Mason ST, Fibiger HC (1979) Current concepts. I. Anxiety: the locus coeruleus disconnection. Life Sci 25(26):2141–2147
Matsuda LA, Bonner TI, Lolait SJ (1992) Cannabinoid receptors: which cells, where, how, and why? NIDA Res Monogr 126:48–56
Matsuda LA, Lolait SJ, Brownstein MJ, Young AC, Bonner TI (1990) Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature 346(6284):561–564
McEwen B (1999) Development of the cerebral cortex: XIII. Stress and brain development: II. J Am Acad Child Adolesc Psychiatry 38(1):101–103
McEwen BS, Gianaros PJ (2011) Stress- and allostasis-induced brain plasticity. Annu Rev Med 62:431–445
Miederer I, Maus S, Zwiener I, Podoprygorina G, Meshcheryakov D, Lutz B, Schreckenberger M (2013) Evaluation of cannabinoid type 1 receptor expression in the rat brain using [(1)(8)F]MK-9470 microPET. Eur J Nucl Med Mol Imag 40(11):1739–1747
Milad MR, Quirk GJ (2002) Neurons in medial prefrontal cortex signal memory for fear extinction. Nature 420(6911):70–74
Milad MR, Rauch SL, Pitman RK, Quirk GJ (2006) Fear extinction in rats: implications for human brain imaging and anxiety disorders. Biol Psychol 73(1):61–71
Morsink MC, Joels M, Sarabdjitsingh RA, Meijer OC, de Kloet ER, Datson NA (2006) The dynamic pattern of glucocorticoid receptor-mediated transcriptional responses in neuronal PC12 cells. J Neurochem 99(4):1282–1298
Munro S, Thomas KL, Abu-Shaar M (1993) Molecular characterization of a peripheral receptor for cannabinoids. Nature 365(6441):61–65
Nagano-Saito A, Dagher A, Booij L, Gravel P, Welfeld K, Casey KF, Leyton M, Benkelfat C (2013) Stress-induced dopamine release in human medial prefrontal cortex–18F-fallypride/PET study in healthy volunteers. Synapse (New York, N.Y.) 67(12):821–830
Niciu MJ, Ionescu DF, Richards EM, Zarate CA Jr (2013) Glutamate and its receptors in the pathophysiology and treatment of major depressive disorder. J Neural Transm. doi:10.1007/s00702-013-1130-x
Oliver KR, Kinsey AM, Wainwright A, Sirinathsinghji DJ (2000) Localization of 5-ht(5A) receptor-like immunoreactivity in the rat brain. Brain Res 867(1–2):131–142
O’Shea RD (2002) Roles and regulation of glutamate transporters in the central nervous system. Clin Exp Pharmacol Physiol 29(11):1018–1023
Ossewaarde L, Qin S, van Marle HJ, van Wingen GA, Fernandez G, Hermans EJ (2011) Stress-induced reduction in reward-related prefrontal cortex function. NeuroImage 55(1):345–352
Pacak K, Palkovits M (2001) Stressor specificity of central neuroendocrine responses: implications for stress-related disorders. Endocr Rev 22(4):502–548
Pascucci T, Andolina D, Mela IL, Conversi D, Latagliata C, Ventura R, Puglisi-Allegra S, Cabib S (2009) 5-Hydroxytryptophan rescues serotonin response to stress in prefrontal cortex of hyperphenylalaninaemic mice. Int J Neuropsychopharmacol/official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP) 12(8):1067–1079
Pasqualetti M, Ori M, Castagna M, Marazziti D, Cassano GB, Nardi I (1999) Distribution and cellular localization of the serotonin type 2C receptor messenger RNA in human brain. Neuroscience 92(2):601–611
Passerin AM, Cano G, Rabin BS, Delano BA, Napier JL, Sved AF (2000) Role of locus coeruleus in foot shock-evoked Fos expression in rat brain. Neuroscience 101(4):1071–1082
Patel KD, Davison JS, Pittman QJ, Sharkey KA (2010) Cannabinoid CB(2) receptors in health and disease. Curr Med Chem 17(14):1393–1410
Pazos A, Probst A, Palacios JM (1987a) Serotonin receptors in the human brain—III. Autoradiographic mapping of serotonin-1 receptors. Neuroscience 21(1):97–122
Pazos A, Probst A, Palacios JM (1987b) Serotonin receptors in the human brain—IV. Autoradiographic mapping of serotonin-2 receptors. Neuroscience 21(1):123–139
Pecoraro N, Dallman MF, Warne JP, Ginsberg AB, Laugero KD, la Fleur SE, Houshyar H, Gomez F, Bhargava A, Akana SF (2006) From Malthus to motive: how the HPA axis engineers the phenotype, yoking needs to wants. Prog Neurobiol 79(5–6):247–340
Pertovaara A (2013) The noradrenergic pain regulation system: a potential target for pain therapy. Eur J Pharmacol 716(1–3):2–7
Pertwee RG (2008) Ligands that target cannabinoid receptors in the brain: from THC to anandamide and beyond. Addict Biol 13(2):147–159
Pirnik Z, Mravec B, Kiss A (2004) Fos protein expression in mouse hypothalamic paraventricular (PVN) and supraoptic (SON) nuclei upon osmotic stimulus: colocalization with vasopressin, oxytocin, and tyrosine hydroxylase. Neurochem Int 45(5):597–607
Popoli M, Yan Z, McEwen BS, Sanacora G (2011) The stressed synapse: the impact of stress and glucocorticoids on glutamate transmission. Nat Rev Neurosci 13(1):22–37
Pruessner JC, Champagne F, Meaney MJ, Dagher A (2004) Dopamine release in response to a psychological stress in humans and its relationship to early life maternal care: a positron emission tomography study using [11C]raclopride. J Neurosci: Off J Soc Neurosci 24(11):2825–2831
Qin S, Hermans EJ, van Marle HJ, Luo J, Fernandez G (2009) Acute psychological stress reduces working memory-related activity in the dorsolateral prefrontal cortex. Biol Psychiatry 66(1):25–32
Rademacher DJ, Meier SE, Shi L, Ho WS, Jarrahian A, Hillard CJ (2008) Effects of acute and repeated restraint stress on endocannabinoid content in the amygdala, ventral striatum, and medial prefrontal cortex in mice. Neuropharmacology 54(1):108–116
Radley JJ, Sawchenko PE (2011) A common substrate for prefrontal and hippocampal inhibition of the neuroendocrine stress response. J Neurosci: Off J Soc Neurosci 31(26):9683–9695
Radley JJ, Williams B, Sawchenko PE (2008) Noradrenergic innervation of the dorsal medial prefrontal cortex modulates hypothalamo-pituitary-adrenal responses to acute emotional stress. J Neurosci: Off J Soc Neurosci 28(22):5806–5816
Rasmussen K, Morilak DA, Jacobs BL (1986a) Single unit activity of locus coeruleus neurons in the freely moving cat. I. During naturalistic behaviors and in response to simple and complex stimuli. Brain Res 371(2):324–334
Rasmussen K, Strecker RE, Jacobs BL (1986b) Single unit response of noradrenergic, serotonergic and dopaminergic neurons in freely moving cats to simple sensory stimuli. Brain Res 369(1–2):336–340
Redmond DE Jr, Huang YH, Snyder DR, Maas JW (1976) Behavioral effects of stimulation of the nucleus locus coeruleus in the stump-tailed monkey Macaca arctoides. Brain Res 116(3):502–510
Reznikov LR, Reagan LP, Fadel JR (2009) Effects of acute and repeated restraint stress on GABA efflux in the rat basolateral and central amygdala. Brain Res 1256:61–68
Ruffolo RR Jr, Hieble JP (1994) Alpha-adrenoceptors. Pharmacol Ther 61(1–2):1–64
Russell GM, Henley DE, Leendertz J, Douthwaite JA, Wood SA, Stevens A, Woltersdorf WW, Peeters BW, Ruigt GS, White A, Veldhuis JD, Lightman SL (2010) Rapid glucocorticoid receptor-mediated inhibition of hypothalamic-pituitary-adrenal ultradian activity in healthy males. J Neurosci: Off J Soc Neurosci 30(17):6106–6115
Sakai K, Crochet S (2001) Differentiation of presumed serotonergic dorsal raphe neurons in relation to behavior and wake-sleep states. Neuroscience 104(4):1141–1155
Samuels ER, Szabadi E (2008) Functional neuroanatomy of the noradrenergic locus coeruleus: its roles in the regulation of arousal and autonomic function part I: principles of functional organisation. Curr Neuropharmacol 6(3):235–253
Sapolsky RM, Krey LC, McEwen BS, Rainbow TC (1984) Do vasopressin-related peptides induce hippocampal corticosterone receptors? Implications for aging. J Neurosci: Off J Soc Neurosci 4(6):1479–1485
Sara SJ (2009) The locus coeruleus and noradrenergic modulation of cognition. Nat Rev Neurosci 10(3):211–223
Schoofs D, Pabst S, Brand M, Wolf OT (2013) Working memory is differentially affected by stress in men and women. Behav Brain Res 241:144–153
Schultz W (2007) Behavioral dopamine signals. Trends Neurosci 30(5):203–210
Selye H (1936) A syndrome produced by diverse nocuous agents. Nature 138:32
Shors TJ, Weiss C, Thompson RF (1992) Stress-induced facilitation of classical conditioning. Science (New York, N.Y.) 257(5069):537–539
Sinclair D, Purves-Tyson TD, Allen KM, Weickert CS (2014) Impacts of stress and sex hormones on dopamine neurotransmission in the adolescent brain. Psychopharmacology 231(8):1581–1599
Singewald GM, Rjabokon A, Singewald N, Ebner K (2011) The modulatory role of the lateral septum on neuroendocrine and behavioral stress responses. Neuropsychopharmacol: Off Publ Am Coll Neuropsychopharmacol 36(4):793–804
Stasi C, Bellini M, Bassotti G, Blandizzi C, Milani S (2014) Serotonin receptors and their role in the pathophysiology and therapy of irritable bowel syndrome. Tech Coloproctol 18(17):613–621
Sudhof TC, Rothman JE (2009) Membrane fusion: grappling with SNARE and SM proteins. Science (New York, N.Y.) 323(5913):474–477
Sugiura T, Kishimoto S, Oka S, Gokoh M (2006) Biochemistry, pharmacology and physiology of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand. Prog Lipid Res 45(5):405–446
Sugiura T, Waku K (2000) 2-Arachidonoylglycerol and the cannabinoid receptors. Chem Phys Lipids 108(1–2):89–106
Summers RJ, McMartin LR (1993) Adrenoceptors and their second messenger systems. J Neurochem 60(1):10–23
Taghzouti K, le Moal M, Simon H (1991) Suppression of noradrenergic innervation compensates for behavioral deficits induced by lesion of dopaminergic terminals in the lateral septum. Brain Res 552(1):124–128
Tasker JG, Herman JP (2011) Mechanisms of rapid glucocorticoid feedback inhibition of the hypothalamic-pituitary-adrenal axis. Stress (Amsterdam, Netherlands) 14(4):398–406
Tepper SJ, Rapoport AM, Sheftell FD (2002) Mechanisms of action of the 5-HT1B/1D receptor agonists. Arch Neurol 59(7):1084–1088
Thomas DR, Hagan JJ (2004) 5-HT7 receptors. Curr Drug Targets CNS Neurol Disord 3(1):81–90
Thompson AJ, Lummis SC (2007) The 5-HT3 receptor as a therapeutic target. Expert Opin Ther Targets 11(4):527–540
Ueda N, Katayama K, Goparaju SK, Kurahashi Y, Yamanaka K, Suzuki H, Yamamoto S (2002) Catalytic properties of purified recombinant anandamide amidohydrolase. Adv Exp Med Biol 507:251–256
Ulrich-Lai YM, Herman JP (2009) Neural regulation of endocrine and autonomic stress responses. Nat Rev Neurosci 10(6):397–409
Uriguen L, Perez-Rial S, Ledent C, Palomo T, Manzanares J (2004) Impaired action of anxiolytic drugs in mice deficient in cannabinoid CB1 receptors. Neuropharmacology 46(7):966–973
Vallone D, Picetti R, Borrelli E (2000) Structure and function of dopamine receptors. Neurosci Biobehav Rev 24(1):125–132
van Sickle MD, Duncan M, Kingsley PJ, Mouihate A, Urbani P, Mackie K, Stella N, Makriyannis A, Piomelli D, Davison JS, Marnett LJ, di Marzo V, Pittman QJ, Patel KD, Sharkey KA (2005) Identification and functional characterization of brainstem cannabinoid CB2 receptors. Science (New York, N.Y.) 310(5746):329–332
Varnas K, Halldin C, Hall H (2004) Autoradiographic distribution of serotonin transporters and receptor subtypes in human brain. Hum Brain Mapp 22(3):246–260
Wade MR, Degroot A, Nomikos GG (2006) Cannabinoid CB1 receptor antagonism modulates plasma corticosterone in rodents. Eur J Pharmacol 551(1–3):162–167
Wand GS, Oswald LM, McCaul ME, Wong DF, Johnson E, Zhou Y, Kuwabara H, Kumar A (2007) Association of amphetamine-induced striatal dopamine release and cortisol responses to psychological stress. Neuropsychopharmacol: Off Publ Am Coll Neuropsychopharmacol 32(11):2310–2320
Watt MJ, Burke AR, Renner KJ, Forster GL (2009) Adolescent male rats exposed to social defeat exhibit altered anxiety behavior and limbic monoamines as adults. Behav Neurosci 123(3):564–576
Wellman CL, Izquierdo A, Garrett JE, Martin KP, Carroll J, Millstein R, Lesch KP, Murphy DL, Holmes A (2007) Impaired stress-coping and fear extinction and abnormal corticolimbic morphology in serotonin transporter knock-out mice. J Neurosci: Off J Soc Neurosci 27(3):684–691
Wilson RI, Nicoll RA (2002) Endocannabinoid signaling in the brain. Science (New York, N.Y.) 296(5568):678–682
Xi ZX, Peng XQ, Li X, Song R, Zhang HY, Liu QR, Yang HJ, Bi GH, Li J, Gardner EL (2011) Brain cannabinoid CB(2) receptors modulate cocaine’s actions in mice. Nat Neurosci 14(9):1160–1166
Yuen EY, Liu W, Karatsoreos IN, Feng J, McEwen BS, Yan Z (2009) Acute stress enhances glutamatergic transmission in prefrontal cortex and facilitates working memory. Proc Natl Acad Sci U S A 106(33):14075–14079
Ziegler DR, Cass WA, Herman JP (1999) Excitatory influence of the locus coeruleus in hypothalamic-pituitary-adrenocortical axis responses to stress. J Neuroendocrinol 11(5):361–369
Acknowledgments
Dr. Lapiz-Bluhm receives funding from the Robert Wood Johnson Nurse Faculty Program. She sincerely thanks Dr. Carrie Jo Braden, Dr. James Michael Bluhm and Dr. Charles Marsden for taking the time to read the manuscript.
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Lapiz-Bluhm, M.D. (2014). Impact of Stress on Prefrontal Glutamatergic, Monoaminergic and Cannabinoid Systems. In: Pariante, C., Lapiz-Bluhm, M. (eds) Behavioral Neurobiology of Stress-related Disorders. Current Topics in Behavioral Neurosciences, vol 18. Springer, Berlin, Heidelberg. https://doi.org/10.1007/7854_2014_331
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DOI: https://doi.org/10.1007/7854_2014_331
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