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ASD: Psychopharmacologic Treatments and Neurophysiologic Underpinnings

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Electrophysiology and Psychophysiology in Psychiatry and Psychopharmacology

Part of the book series: Current Topics in Behavioral Neurosciences ((CTBN,volume 21))

Abstract

Autism Spectrum Disorder encompasses a range of neurodevelopmental disorders characterized by early deficits in social communication in addition to restricted and repetitive behaviors. Symptoms are increasingly understood to be associated with abnormalities in the coordination of neuronal assemblies responsible for processing information essential for early adaptive behaviors. Pharmacologic treatments carry evidence for clinically significant benefit of multiple impairing symptoms of ASD, yet these benefits are limited and range across a broad spectrum of medication classes, making it difficult to characterize associated neurochemical impairments. Increasing prevalence of both ASD and its pharmacologic management calls for greater understanding of the neurophysiologic basis of the disorder. This paper reviews underlying alterations in local brain regions and coordination of brain activation patterns during both resting state and task-related processes. We propose that new pharmacologic treatments may focus on realigning trajectories of network specialization across development by working in combination with behavioral treatments to enhance social and emotional learning by bolstering the impact of experience-induced plasticity on neuronal network connectivity.

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Acknowledgment

Support for this project was provided to Dr. Webb by the National Institutes of Health (R01-HD064820, R01-MH10028, HHSN271201200005I).

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Authors and Affiliations

  1. University of Washington Department of Psychiatry and Behavioral Sciences, Seattle, United States of America

    Ian Kodish & Carol M. Rockhill

  2. University of Washington Department of Psychiatry and Behavioral Sciences, Seattle Children’s Research Institute, Po Box 5371, M/S CW8-6, Seattle, 98145, United States of America

    Sara J. Webb

Authors
  1. Ian Kodish
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  2. Carol M. Rockhill
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  3. Sara J. Webb
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Corresponding author

Correspondence to Sara J. Webb .

Editor information

Editors and Affiliations

  1. Department of Psychology,, Department of Psychology, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, United Kingdom

    Veena Kumari

  2. Center for Neuropsych Research of Traumatic Stress, Charles University Department of Psychiatry, Prague, Czech Republic

    Petr Bob

  3. Department of Psychiatry and Neurosciences, Department of Psychiatry and Neurosciences, University of Missouri Kansas City (UMKC), Kansas City, Missouri, USA

    Nash N. Boutros

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Kodish, I., Rockhill, C.M., Webb, S.J. (2014). ASD: Psychopharmacologic Treatments and Neurophysiologic Underpinnings. In: Kumari, V., Bob, P., Boutros, N. (eds) Electrophysiology and Psychophysiology in Psychiatry and Psychopharmacology. Current Topics in Behavioral Neurosciences, vol 21. Springer, Cham. https://doi.org/10.1007/7854_2014_298

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