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The Interaction Between Pain and Social Behavior in Humans and Rodents

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Behavioral Neurobiology of Chronic Pain

Part of the book series: Current Topics in Behavioral Neurosciences ((CTBN,volume 20))

Abstract

Pain elicits behaviors in humans and nonhuman animals that serve as social cues. Pain behaviors serve a communicative function in humans, and this may be true as well in other animals. This review considers the current evidence for modulation of acute pain in different social contexts in humans and rodents, with a focus on dyadic social interactions. Increasing data supports the ability of social buffering, emotional contagion (a form of empathy), vicarious learning, and social stress to modulate pain sensitivity and pain behavior in mice and rats. As in humans, many of these social factors operate, and affect pain, in a sex-dependent manner. The development of a true social neuroscience of pain, with detailed explication of the underlying neurochemistry and genetics, now seems achievable.

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References

  • Agren G, Olsson C, Uvnas-Moberg K, Lundeberg T (1997a) Olfactory cues from an oxytocin-injected male rat can reduce energy loss in its cagemates. NeuroReport 8:2551–2555

    CAS  PubMed  Google Scholar 

  • Agren G, Uvnas-Moberg K, Lundeberg T (1997b) Olfactory cues from an oxytocin-injected male rat can induce anti-nociception in its cagemates. NeuroReport 8:3073–3076

    CAS  PubMed  Google Scholar 

  • Asiaksen PM, Myrbakk IN, Hoifodt RS, Flaten MA (2007) The effect of experimenter gender on autonomic and subjective responses to pain stimuli. Pain 129:260–268

    Google Scholar 

  • Baron-Cohen S, Wheelwright S (2004) The empathy quotient: an investigation of adults with Asperger syndrome or high functioning autism, and normal sex differences. J Aut Dev Disorders 34:163–175

    Google Scholar 

  • Baum M (1969) Extinction of an avoidance response motivated by intense fear: social facilitation of the action of response prevention (flooding) in rats. Behav Res Ther 7:57–62

    CAS  PubMed  Google Scholar 

  • Becker A, Grecksch G, Schroder H (2006) Pain sensitivity is altered in animals after subchronic ketamine treatment. Psychopharmacology 189:237–247

    CAS  PubMed  Google Scholar 

  • Ben-ami Bartal I, Decety J, Mason P (2011) Empathy and pro-social behavior in rats. Science 334:1427–1430

    PubMed  Google Scholar 

  • Berman D, Rodin BE (1982) The influence of housing condition on autotomy following dorsal rhizotomy in rats. Pain 13:307–311

    CAS  PubMed  Google Scholar 

  • Bernhardt BC, Singer T (2012) The neural basis of empathy. Annu Rev Neurosci 35:1–23

    CAS  PubMed  Google Scholar 

  • Blanchard RJ, Blanchard DC, Rodgers J, Weiss SM (1991) The characterization and modelling of antipredator defensive behavior. Neurosci Biobehav Rev 14:463–472

    Google Scholar 

  • Botvininck M, Jha AP, Bylsma LM, Fabian SA, Solomon PE, Prkachin KM (2005) Viewing facial expressions of pain engages cortical areas involved in the direct experience of pain. Neuroimage 25:312–319

    Google Scholar 

  • Bredy TW, Barad M (2009) Social modulation of associative fear learning by pheromone communication. Learn Mem 16:12–18

    PubMed Central  PubMed  Google Scholar 

  • Brodkin ES, Hagemann A, Nemetski SM, Silver LM (2004) Social approach-avoidance behavior of inbred mouse strains towards DBA/2 mice. Brain Res 1002:151–157

    CAS  PubMed  Google Scholar 

  • Brown JL, Sheffield D, Leary MR, Robinson ME (2003) Social support and experimental pain. Psychosom Med 65:276–283

    PubMed  Google Scholar 

  • Butler RK, Finn DP (2009) Stress-induced analgesia. Prog Neurobiol 88:184–202

    CAS  PubMed  Google Scholar 

  • Carter CS, Boone EM, Pournajafi-Nazarloo H, Bales KL (2009) Consequences of early experiences and exposure to oxytocin and vasopressin are sexually dimorphic. Dev Neurosci 31:332–341

    CAS  PubMed Central  PubMed  Google Scholar 

  • Chambers CT, Craig KD, Bennett SM (2002) The impact of maternal behavior on children’s pain experiences: an experimental analysis. J Pediat Psychol 27:293–301

    Google Scholar 

  • Chen Q, Panksepp JB, Lahvis GP (2009) Empathy is moderated by genetic background in mice. PLoS One 4:e4387

    PubMed Central  PubMed  Google Scholar 

  • Cheng Y, Chou KH, Decety J, Chen IY, Hung D, Tzeng OJ, Lin CP (2009) Sex differences in the neuroanatomy of human mirror-neuron system: a voxel-based morphometric investigation. Neuroscience 158:713–720

    CAS  PubMed  Google Scholar 

  • Church RM (1959) Emotional reactions of rats to the pain of others. J Comp Physiol Psychol 52:132–134

    CAS  PubMed  Google Scholar 

  • Cogan R, Spinnato JA (1988) Social support during premature labor: effects on labor and the newborn. J Psychosom Obstet Gynecol 8:209–216

    Google Scholar 

  • Coll MP, Budell L, Rainville P, Decety J, Jackson PL (2012) The role of gender in the interaction between self-pain and the perception of pain in others. J Pain 13:695–703

    PubMed  Google Scholar 

  • Coudereau J-P, Monier C, Bourre J-M, Frances H (1997) Effect of isolation on pain threshold and on different effects of morphine. Prog Neuropsychopharmacol Biol Psychiat 21:997–1018

    CAS  Google Scholar 

  • Craig KD, Best H, Ward LM (1975) Social modeling influences on psychophysical judgments of electrical stimulation. J Abnorm Psychol 84:366–373

    CAS  PubMed  Google Scholar 

  • Craig KD, Weiss SM (1971) Vicarious influences on pain-threshold determinations. J Pers Soc Psychol 19:53–59

    CAS  PubMed  Google Scholar 

  • D’Amato FR (1997) Neurobiological and behavioral aspects of recognition in female mice. Physiol Behav 62:1311–1317

    PubMed  Google Scholar 

  • D’Amato FR (1998) Kin interaction enhances morphine analgesia in male mice. Behav Pharmacol 9:369–373

    PubMed  Google Scholar 

  • D’Amato FR, Pavone F (1993) Endogenous opioids: a proximate reward mechanism for kin selection? Behav Neural Biol 60:79–83

    PubMed  Google Scholar 

  • D’Amato FR, Pavone F (1996) Reunion of separated sibling mice: neurobiological and behavioral aspects. Neurobiol Learn Mem 65:9–16

    PubMed  Google Scholar 

  • Davitz JR, Mason DJ (1955) Socially facilitated reduction of a fear response in rats. J Comp Physiol Psychol 48:149–151

    CAS  PubMed  Google Scholar 

  • de Waal FBM (2008) Putting the altruism back into altruism: the evolution of empathy. Annu Rev Psychol 59:279–300

    PubMed  Google Scholar 

  • Decety J, Jackson PL (2004) The functional architecture of human empathy. Behav Cog Neurosci Rev 3:71–100

    Google Scholar 

  • Defeudis FV, Defeudis PA, Somoza E (1976) Altered analgesic responses to morphine in differentially housed mice. Psychopharmacology 49:117–118

    CAS  PubMed  Google Scholar 

  • Demuru E, Palagi E (2012) In bonobos yawn contagion is higher among kin and friends. PLoS One 7:e49613

    CAS  PubMed Central  PubMed  Google Scholar 

  • Devor M, Gilad A, Arbilly M, Nissenbaum J, Yakir B, Raber P, Minert A, Pisante A, Darvasi A (2007) Sex-specific variability and a ‘cage effect’ independently mask a neuropathic pain quantitative trait locus detected in a whole genome scan. Eur J Neurosci 26:681–688

    PubMed  Google Scholar 

  • Donaldson ZR, Young LJ (2009) Oxytocin, vasopressin, and the neurogenetics of sociality. Science 322:900–904

    Google Scholar 

  • Epley SW (1974) Reduction of the behavioral effects of aversive stimulation by the presence of companions. Psychol Bull 81:271–283

    CAS  PubMed  Google Scholar 

  • Fanselow MS (1985) Odors released by stressed rats produce opioid analgesia in unstressed rats. Behav Neurosci 99:589–592

    CAS  PubMed  Google Scholar 

  • Feine JS, Bushnell MC, Miron D, Duncan GH (1991) Sex differences in the perception of noxious heat stimuli. Pain 44:255–262

    CAS  PubMed  Google Scholar 

  • Fillingim RB, Doleys DM, Edwards RR, Lowery D (2003) Spousal responses are differentially associated with clinical variables in women and men with chronic pain. Clin J Pain 19:217–224

    PubMed  Google Scholar 

  • Flor H, Kerns RD, Turk DC (1987) The role of spouse reinforcement, perceived pain, and activity levels of chronic pain patients. J Psychosom Res 31:251–259

    CAS  PubMed  Google Scholar 

  • Gallese V, Fadiga L, Fogassi L, Rizzolatti G (1996) Action recognition in the premotor cortex. Brain 119:593–609

    PubMed  Google Scholar 

  • Geangu E, Benga O, Stahl D, Striano T (2010) Contagious crying beyond the first days of life. Infant Behav Dev 33:279–288

    PubMed  Google Scholar 

  • Gijsbers K, Nicholson F (2005) Experimental pain thresholds influenced by sex of experimenter. Percept Mot Skills 101:803–807

    CAS  PubMed  Google Scholar 

  • Gil KM, Keefe FJ, Crisson JE, van Dalfsen PJ (1987) Social support and pain behavior. Pain 29:209–217

    CAS  PubMed  Google Scholar 

  • Godinho F, Magnin M, Frot M, Perchet C, Garcia-Larrea L (2006) Emotional modulation of pain: is it the sensation or what we recall? J Neurosci 26:11454–11461

    CAS  PubMed  Google Scholar 

  • Hadjistavropoulos T, Craig KD, Duck S, Cano A, Goubert L, Jackson PL, Mogil JS, Rainville P, Sullivan MJ, De C Williams AC, Vervoort T, Fitzgerald TD (2011) A biopsychosocial formulation of pain communication. Psychol Bull 137:910–939

    PubMed  Google Scholar 

  • Hall JA (1978) Gender effects in decoding nonverbal cues. Psychol Bull 85:845–858

    Google Scholar 

  • Hall JC (1955) Some conditions of anxiety extinction. J Abnorm Soc Psychol 51:126–132

    CAS  Google Scholar 

  • Han S, Fan Y, Mao L (2008) Gender difference in empathy for pain: an electrophysiological investigation. Brain Res 1196:85–93

    CAS  PubMed  Google Scholar 

  • Hatfield E, Cacioppo JT, Rapson RL (1993) Emotional contagion. Curr Dir Psychol Sci 2:96–99

    Google Scholar 

  • Huhman KL, Moore TO, Ferris CF, Mougey EH, Meyerhoff JL (1991) Acute and repeated exposure to social conflict in male golden hamsters: increases in plasma POMC-peptides and cortisol and decreases in plasma testosterone. Horm Behav 25:206–216

    CAS  PubMed  Google Scholar 

  • Imbe H, Iwai-Liao Y, Senba E (2006) Stress-induced hyperalgesia: animal models and putative mechanisms. Front Biosci 11:2179–2192

    CAS  PubMed  Google Scholar 

  • Jackson T, Huang X, Chen H, Phillips H (2009) Effects of threatening information on interpersonal responses to pain. Eur J Pain 13:431–438

    PubMed  Google Scholar 

  • Jackson T, Iezzi T, Chen H, Ebnet S, Eglitis K (2005) Gender, interpersonal transactions, and the perception of pain: an experimental analysis. J Pain 6:228–236

    PubMed  Google Scholar 

  • Jeon D, Kim S, Chetana M, Jo D, Ruley HE, Lin S-Y, Rabah D, Kinet J-P, Shin H-S (2010) Observational fear learning involves affective pain system and Cav1.2 Ca2+ channels in ACC. Nat Neurosci 13:482–488

    CAS  PubMed Central  PubMed  Google Scholar 

  • Kallai I, Barke A, Voss U (2004) The effects of experimenter characteristics on pain reports in women and men. Pain 112:142–147

    PubMed  Google Scholar 

  • Kavaliers M, Choleris E, Colwell DD (2001) Learning from others to cope with biting flies: social learning of fear-induced conditioned analgesia and active avoidance. Behav Neurosci 115:661–674

    CAS  PubMed  Google Scholar 

  • Keating SCJ, Thomas AA, Flecknell PA, Leach MC (2012) Evaluation of EMLA cream for preventing pain during tattooing of rabbits: changes in physiological, behavioural and facial expression responses. PLoS One 7:e44437

    CAS  PubMed Central  PubMed  Google Scholar 

  • Kerns RD, Rosenberg R, Otis JD (2002) Self-appraised problem solving and pain-relevant social support as predictors of the experience of chronic pain. Annals Behav Med 24:100–105

    Google Scholar 

  • Kiyokawa Y, Kikusui T, Takeuchi Y, Mori Y (2004) Partner’s stress status influences social buffering effects in rats. Behav Neurosci 118:798–804

    PubMed  Google Scholar 

  • Knapska E, Mikosz M, Werka T, Maren S (2010) Social modulation of learning in rats. Learn Mem 17:35–42

    PubMed Central  PubMed  Google Scholar 

  • Knapska E, Nikolaev E, Boguszewski P, Walasek G, Blaszczyk J, Kaczmarek L, Werka T (2006) Between-subject transfer of emotional information evokes specific pattern of amygdala activation. Proc Natl Acad Sci USA 103:3858–3862

    CAS  PubMed Central  PubMed  Google Scholar 

  • Krahe C, Springer A, Weinman JA, Fotopoulou A (2013) The social modulation of pain: others as predictive signals of salience: a systematic review. Front Human Neurosci 7:386

    Google Scholar 

  • Kulik JA, Mahler HI (1989) Social support and recovery from surgery. Health Psychol 8:221–238

    CAS  PubMed  Google Scholar 

  • Langford DL, Bailey AL, Chanda ML, Clarke SE, Drummond TE, Echols S, Glick S, Ingrao J, Klassen-Ross T, Lacroix-Fralish ML, Matsumiya L, Sorge RE, Sotocinal SB, Tabaka JM, Wong D, van den Maagdenberg AMJM, Ferrari MD, Craig KD, Mogil JS (2010a) Coding of facial expressions of pain in the laboratory mouse. Nat Meth 7:447–449

    CAS  Google Scholar 

  • Langford DL, Crager SE, Shehzad Z, Smith SB, Sotocinal SG, Levenstadt JS, Chanda ML, Levitin DJ, Mogil JS (2006) Social modulation of pain as evidence for empathy in mice. Science 312:1967–1970

    CAS  PubMed  Google Scholar 

  • Langford DL, Tuttle AH, Briscoe C, Harvey-Lewis C, Baran I, Gleeson P, Fischer DB, Buonora M, Sternberg WF, Mogil JS (2011) Varying perceived social threat modulates pain behavior in male mice. J Pain 12:125–132

    PubMed  Google Scholar 

  • Langford DL, Tuttle AH, Brown K, Deschenes S, Fischer DB, Mutso A, Root KC, Sotocinal SG, Stern MA, Mogil JS, Sternberg WF (2010b) Social approach to pain in laboratory mice. Soc Neurosci 5:163–170

    PubMed  Google Scholar 

  • Latane B (1969) Gregariousness and fear in laboratory rats. J Exp Soc Psychol 5:61–69

    Google Scholar 

  • Latane B, Glass DC (1968) Social and nonsocial attraction in rats. J Pers Soc Psychol 9:142–146

    CAS  PubMed  Google Scholar 

  • Leshem M, Sherman M (2006) Troubles shared are troubles halved: stress in rats is reduced in proportion to social propinquity. Physiol Behav 89:399–401

    CAS  PubMed  Google Scholar 

  • Levenson RW, Ruef AM (1992) Empathy: a physiological substrate. J Pers Soc Psychol 63:234–246

    CAS  PubMed  Google Scholar 

  • Levine FM, de Simone LL (1991) The effects of experimenter gender on pain report in male and female subjects. Pain 44:69–72

    CAS  PubMed  Google Scholar 

  • Loggia ML, Mogil JS, Bushnell MC (2007) Empathy hurts: compassion for another increases both sensory and affective components of pain perception. Pain 136:168–176

    PubMed  Google Scholar 

  • López-Martínez AE, Esteve-Zarazaga R, Ramírez-Maestre C (2008) Perceived social support and coping responses are independent variables explaining pain adjustment among chronic pain patients. J Pain 9:373–379

    PubMed  Google Scholar 

  • Mackay-Sim A, Laing DG (1981) The sources of odors from stressed rats. Physiol Behav 27:511–513

    CAS  PubMed  Google Scholar 

  • Massen JJ, Vermunt DA, Sterck EH (2012) Male yawning is more contagious than female yawning among chimpanzees (Pan troglodytes). PLoS One 7:e40697

    CAS  PubMed Central  PubMed  Google Scholar 

  • McClelland LE, McCubbin JA (2008) Social influence and pain response in women and men. J Behav Med 31:413–420

    PubMed  Google Scholar 

  • Miczek KA, Thompson ML, Shuster L (1982) Opioid-like analgesia in defeated mice. Science 215:1520–1522

    CAS  PubMed  Google Scholar 

  • Miller ML, Gallup AC, Vogel AR, Vicario SM, Clark AB (2012) Evidence for contagious behaviors in budgerigars (Melopsittacus undulatus): an observational study of yawning and stretching. Behav Processes 89:264–270

    PubMed  Google Scholar 

  • Mogil JS (2012) Sex differences in pain and pain inhibition: multiple explanations of a controversial phenomenon. Nat Rev Neurosci 13:859–866

    CAS  PubMed  Google Scholar 

  • Mogil JS, Sorge RE, Lacroix-Fralish ML, Smith SB, Fortin A, Sotocinal SG, Ritchie J, Austin J-S, Schorscher-Petcu A, Melmed K, Czerminsky J, Bittong RA, Mokris JB, Neubert JK, Campbell CM, Edwards RR, Campbell JN, Crawley JN, Lariviere WR, Wallace MR, Sternberg WF, Balaban CD, Belfer I, Fillingim RB (2011) Pain sensitivity and vasopressin analgesia are mediated by a gene-sex-environment interaction. Nat Neurosci 14:1569–1573

    CAS  PubMed Central  PubMed  Google Scholar 

  • Monassi CR, Bandler R, Keay KA (2003) A subpopulation of rats show social and sleep-waking changes typical of chronic neuropathic pain following peripheral nerve injury. Eur J Neurosci 17:1907–1920

    PubMed  Google Scholar 

  • Morrison I, Lloyd D, di Pellegrino G, Roberts N (2004) Vicarious responses to pain in anterior cingulate cortex: is empathy a multisensory issue? Cogn Affect Behav Neurosci 4:270–278

    PubMed  Google Scholar 

  • Nowbahari E, Scohier A, Durand J-L, Hollis KL (2009) Ants, Cataglyphis cursor, use precisely directed rescue behavior to free entrapped relatives. PLoS One 4:e6573

    PubMed Central  PubMed  Google Scholar 

  • Olsson A, Phelps EA (2007) Social learning of fear. Nat Neurosci 10:1095–1102

    CAS  PubMed  Google Scholar 

  • Pickens J, Field T (1993) Facial expressivity in infants of depressed mothers. Dev Psychol 29:986–988

    Google Scholar 

  • Pilcher CWT, Browne J (1982) Environmental crowding modifies responding to noxious stimuli and the effects of μ- and κ-agonists. Life Sci 31:1213–1216

    CAS  PubMed  Google Scholar 

  • Platek SM, Critton SR, Myers TE, Gallup GG Jr (2003) Contagious yawning: the role of self-awareness and mental state attribution. Cogn Brain Res 17:223–227

    Google Scholar 

  • Preston SD, de Waal FBM (2002) Empathy: its ultimate and proximate bases. Behav Brain Sci 25:1–72

    PubMed  Google Scholar 

  • Proverbio AM, Adorni R, Zani A, Trestianu L (2009) Sex differences in the brain response to affective scenes with or without humans. Neuropsychologia 47:2374–2388

    PubMed  Google Scholar 

  • Puglisi-Allegra S, Oliverio A (1983) Social isolation: effects on pain threshold and stress-induced analgesia. Pharmacol Biochem Behav 19:6479–6681

    Google Scholar 

  • Raab A, Seizinger BR, Herz A (1985) Continuous social defeat induces an increase of endogenous opioids in discrete brain areas of the mongolian gerbil. Peptides 6:387–391

    CAS  PubMed  Google Scholar 

  • Raber P, Devor M (2002) Social variables affect phenotype in the neuroma model of neuropathic pain. Pain 97:139–150

    PubMed  Google Scholar 

  • Rainville P, Duncan GH, Price DD, Carrier B, Bushnell MC (1997) Pain affect encoded in human anterior cingulate but not somatosensory cortex. Science 277:968–971

    CAS  PubMed  Google Scholar 

  • Rasmussen EW (1939) Social facilitation: an experimental investigation with albino rats. Acta Psychol 4:275–294

    Google Scholar 

  • Rice GE, Gainer P (1962) ‘Altruism’ in the albino rat. J Comp Physiol Psychol 55:123–125

    CAS  PubMed  Google Scholar 

  • Robinson DA, Wei F, Wang GD, Li P, Kim SJ, Vogt SK, Muglia LJ, Zhuo M (2002) Oxytocin mediates stress-induced analgesia in adult mice. J Physiol 540:593–606

    CAS  PubMed Central  PubMed  Google Scholar 

  • Rodgers RJ, Hendrie CA (1983) Social conflict activates status-dependent endogenous analgesic or hyperalgesic mechanisms in male mice: effects of naloxone on nociception and behaviour. Physiol Behav 30:775–780

    CAS  PubMed  Google Scholar 

  • Romero T, Konno A, Hasegawa T (2013) Familiarity bias and physiological responses in contagious yawning by dogs support link to empathy. PLoS One 8:e71365

    CAS  PubMed Central  PubMed  Google Scholar 

  • Rutte C, Taborsky M (2007) Generalized reciprocity in rats. PLoS Biol 5:e196

    PubMed Central  PubMed  Google Scholar 

  • Schorscher-Petcu A, Sotocinal S, Ciura S, Dupre A, Ritchie J, Sorge RE, Crawley JN, Hu S-B, Nishimori K, Young LJ, Tribollet E, Quirion R, Mogil JS (2010) Oxytocin-induced analgesia and scratching are mediated by the vasopressin-1A receptor in the mouse. J Neurosci 30:8274–8284

    CAS  PubMed Central  PubMed  Google Scholar 

  • Senju A, Maeda M, Kikuchi Y, Hasegawa T, Tojo Y, Osanai H (2007) Absence of contagious yawning in children with autism spectrum disorder. Biol Lett 3:706–708

    PubMed Central  PubMed  Google Scholar 

  • Singer T, Seymour B, O’Doherty J, Kaube H, Dolan RJ, Frith CD (2004) Empathy for pain involves the affective but not sensory components of pain. Science 303:1157–1162

    CAS  PubMed  Google Scholar 

  • Singer T, Seymour B, O’Doherty J, Stephan KE, Dolan RJ, Frith CD (2006) Empathic neural responses are modulated by the perceived fairness of others. Nature 439:466–469

    CAS  PubMed Central  PubMed  Google Scholar 

  • Sotocinal SG, Sorge RE, Zaloum A, Tuttle AH, Martin LJ, Wieskopf JS, Mapplebeck JCS, Wei P, Zhan S, Zhang S, McDougall JJ, King OD, Mogil JS (2011) The rat grimace scale: a partially automated method for quantifying pain in the laboratory rat via facial expressions. Mol Pain 7:55

    PubMed Central  PubMed  Google Scholar 

  • Spinka M (2012) Social dimension of emotions and its implication for animal welfare. Appl Anim Behav Sci 138:170–181

    Google Scholar 

  • Taylor SE, Klein LC, Lewis BP, Gruenewald TL, Gurung RAR, Updegraff JA (2000) Biobehavioral responses to stress in females: tend-and-befriend, not fight-or-flight. Psychol Rev 107:411–429

    CAS  PubMed  Google Scholar 

  • Thompson CI, Brannon AJ, Heck AL (2003) Emotional fever after habituation to the temperature-recording procedure. Physiol Behav 80:103–108

    CAS  PubMed  Google Scholar 

  • Valenta JG, Rigby MK (1968) Discrimination of the odor of stressed rats. Science 161:599–601

    CAS  PubMed  Google Scholar 

  • Vasconcelos M, Hollis K, Nowbahari E, Kacelnik A (2012) Pro-sociality without empathy. Biol Lett 8:910–912

    PubMed Central  PubMed  Google Scholar 

  • Watanabe S (2012) Distress of mice induces approach behavior but has an aversive property for conspecifics. Behav Process 90:167–173

    Google Scholar 

  • Watanabe S, Ono K (1986) An experimental analysis of “empathic” response: effects of pain reactions of pigeon upon other pigeon’s operant behavior. Behav Process 13:269–277

    CAS  Google Scholar 

  • Weijers HG, Weyers P (1998) Locomotor activity and defecation of rats observed alone and in pairs in repeated open-field sessions. Percept Mot Skills 86:1179–1184

    CAS  PubMed  Google Scholar 

  • Yang CY, Decety J, Lee S, Chen C, Cheng Y (2009) Gender differences in the mu rhythm during empathy for pain: an electroencephalographic study. Brain Res 1251:176–184

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Psychology and Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC, H3A 1B1, Canada

    Loren J. Martin & Alexander H. Tuttle

  2. Department of Psychology, McGill University, 1205 Dr. Penfield Avenue, Montreal, QC, H3A 1B1, Canada

    Jeffrey S. Mogil

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  1. Loren J. Martin
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  2. Alexander H. Tuttle
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  3. Jeffrey S. Mogil
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Correspondence to Jeffrey S. Mogil .

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Editors and Affiliations

  1. University of Kentucky Medical Center, Lexington, Kentucky, USA

    Bradley K. Taylor

  2. Centre for Pain Research, National University of Ireland, Galway, Ireland

    David P. Finn

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Martin, L.J., Tuttle, A.H., Mogil, J.S. (2014). The Interaction Between Pain and Social Behavior in Humans and Rodents. In: Taylor, B., Finn, D. (eds) Behavioral Neurobiology of Chronic Pain. Current Topics in Behavioral Neurosciences, vol 20. Springer, Berlin, Heidelberg. https://doi.org/10.1007/7854_2014_287

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