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Transgenic Rat Models of Huntington’s Disease

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Behavioral Neurobiology of Huntington's Disease and Parkinson's Disease

Part of the book series: Current Topics in Behavioral Neurosciences ((CTBN,volume 22))

Abstract

Several animal models for Huntington’s disease (HD) have been created in order to investigate mechanisms of disease, and to evaluate the potency of novel therapies. Here, we describe the characteristics of the two transgenic rat models: transgenic rat model of HD (fragment model) and the Bacterial Artificial Chromosome HD model (full-length model). We discuss their genetic, behavioural, neuropathological and neurophysiological features.

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Author information

Authors and Affiliations

  1. Departments of Neuroscience and Neurosurgery, Maastricht University Medical Center, Maastricht, The Netherlands

    João Casaca Carreira, Ali Jahanshahi, Dagmar Zeef, Ersoy Kocabicak, Rinske Vlamings & Yasin Temel

  2. Department of Neurosurgery, Ondokuz Mayis University, Samsun, Turkey

    Ersoy Kocabicak

  3. Department of Experimental Therapy, Universitätsklinikum Erlangen, Franz-Penzoldt-Center, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany

    Stephan von Hörsten

  4. European Graduate School of Neuroscience (EURON), Maastricht, The Netherlands

    João Casaca Carreira, Ali Jahanshahi, Dagmar Zeef, Rinske Vlamings & Yasin Temel

Authors
  1. João Casaca Carreira
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  2. Ali Jahanshahi
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  3. Dagmar Zeef
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  4. Ersoy Kocabicak
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  5. Rinske Vlamings
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  6. Stephan von Hörsten
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  7. Yasin Temel
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Corresponding author

Correspondence to Stephan von Hörsten .

Editor information

Editors and Affiliations

  1. Institute of Medical Genetics and Applied Genomics, University of Tuebingen, Tübingen, Germany

    Hoa Huu Phuc Nguyen

  2. Dept of Experimental Medical Science, Lund University, Lund, Sweden

    M. Angela Cenci

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Carreira, J.C. et al. (2013). Transgenic Rat Models of Huntington’s Disease. In: Nguyen, H., Cenci, M. (eds) Behavioral Neurobiology of Huntington's Disease and Parkinson's Disease. Current Topics in Behavioral Neurosciences, vol 22. Springer, Berlin, Heidelberg. https://doi.org/10.1007/7854_2013_245

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