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Effects of Environmental Enrichment Exposure on Synaptic Transmission and Plasticity in the Hippocampus

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Neurogenesis and Neural Plasticity

Part of the book series: Current Topics in Behavioral Neurosciences ((CTBN,volume 15))

Abstract

Exposure to an enriched environment (EE) is beneficial to the structure and function of the brain. The added sensory, social, and spatial complexity of the EE also improves cognitive functions such as memory in both healthy brains and damaged or diseased brains, yet the underlying neural mechanisms of these cognitive improvements are poorly understood. In particular, studies that have examined the effects of EE on cellular function in the hippocampus, a structure critical for memory storage, have produced somewhat confusing results. Experiments performed in ex vivo hippocampal slices have reported a variety of EE effects on synaptic transmission and plasticity in both CA1 and the dentate gyrus. However, together with data from in vivo recordings made during and after the EE treatment, the overall results suggest an evolution of changes in neuronal function in the hippocampus, whereby there is an early transient increase in cell activity and plasticity that gives rise to more subtle long-term enhancements in cellular and network function that may contribute to enhanced hippocampus-dependent cognition.

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Acknowledgments

The work presented from the Abraham laboratory was supported in part by grants from the Royal Society of New Zealand Marsden fund and a James Cook Fellowship to W.C.A.

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Authors and Affiliations

  1. Canadian Center for Behavioral Neuroscience, University of Lethbridge, Lethbridge, AB, Canada

    Michael J. Eckert

  2. Department of Psychology and Brain Health Research Centre, University of Otago, Dunedin, New Zealand

    Wickliffe C. Abraham

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  1. Michael J. Eckert
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  2. Wickliffe C. Abraham
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Correspondence to Michael J. Eckert .

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  1. , INSERM 930, Faculté des Sciences, Parc Grandmont, Tours, 37200, France

    Catherine Belzung

  2. Medical School, Queen's Medical Centre, University of Nottingham, Nottingham, NG7 2UH, United Kingdom

    Peter Wigmore

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Eckert, M.J., Abraham, W.C. (2012). Effects of Environmental Enrichment Exposure on Synaptic Transmission and Plasticity in the Hippocampus. In: Belzung, C., Wigmore, P. (eds) Neurogenesis and Neural Plasticity. Current Topics in Behavioral Neurosciences, vol 15. Springer, Berlin, Heidelberg. https://doi.org/10.1007/7854_2012_215

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