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Brain Imaging in Behavioral Neuroscience pp 65–91Cite as

Neural and Behavioral Endophenotypes in ADHD

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Part of the book series: Current Topics in Behavioral Neurosciences ((CTBN,volume 11))

Abstract

In recent years, descriptive symptom-based approaches of attention deficit hyperactivity disorder (ADHD) have been increasingly replaced by more sophisticated endophenotype-based strategies, better suited to investigate its pathophysiological basis, which is inherently heterogeneous. Measurements derived from neuroimaging techniques such as positron emission tomography (PET) and magnetic resonance imaging (MRI) constitute endophenotypes of growing interest, capable of providing unprecedented windows on neurochemical and neuroanatomical components of psychiatric conditions. This chapter reviews the current state of knowledge regarding putative neural and behavioral endophenotypes of ADHD, across the lifespan. To this end, recent evidence drawn from molecular and structural neuroimaging studies are discussed in the light of widely accepted neuropsychological and pharmacological models of ADHD.

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Authors and Affiliations

  1. Department of Psychiatry, and Behavioral and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK

    Natalia del Campo, Ulrich Müller & Barbara J. Sahakian

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  1. Natalia del Campo
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  2. Ulrich Müller
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Correspondence to Natalia del Campo .

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  1. , UC Davis Imaging Center, University of California at Davis, X Street 4701, Sacramento, 95817, California, USA

    Cameron S. Carter

  2. , Dep of Experimental Psychology/Dep of Ps, University of Cambridge, Downing Site, Cambridge, CB2 3EB, United Kingdom

    Jeffrey W. Dalley

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del Campo, N., Müller, U., Sahakian, B.J. (2012). Neural and Behavioral Endophenotypes in ADHD. In: Carter, C., Dalley, J. (eds) Brain Imaging in Behavioral Neuroscience. Current Topics in Behavioral Neurosciences, vol 11. Springer, Berlin, Heidelberg. https://doi.org/10.1007/7854_2012_200

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