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Behavioral Neurogenetics pp 25–58Cite as

Forward Genetic Approaches to Understanding Complex Behaviors

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Part of the book series: Current Topics in Behavioral Neurosciences ((CTBN,volume 12))

Abstract

Assigning function to genes has long been a focus of biomedical research. Even with complete knowledge of the genomic sequences of humans, mice and other experimental organisms, there is still much to be learned about gene function and control. Ablation or overexpression of single genes using knockout or transgenic technologies has provided functional annotation for many genes, but these technologies do not capture the extensive genetic variation present in existing experimental mouse populations. Researchers have only recently begun to truly appreciate naturally occurring genetic variation resulting from single nucleotide substitutions, insertions, deletions, copy number variation, epigenetic changes (DNA methylation, histone modifications, etc.) and gene expression differences and how this variation contributes to complex phenotypes. In this chapter, we will discuss the benefits and limitations of different forward genetic approaches that capture the genetic variation present in inbred mouse strains and present the utility of these approaches for mapping QTL that influence complex behavioral phenotypes.

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  1. Department of Psychiatry, University of North Carolina, Chapel Hill, NC, 27516, USA

    Lisa M. Tarantino & Amy F. Eisener-Dorman

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Correspondence to Lisa M. Tarantino .

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  1. , Dep of Pharmacology and Therapeutics, School of Pharmacy, College Rd, Cork, 30, Ireland

    John F. Cryan

  2. , Department of Psychiatry and Psychothera, University of Würzburg, Füchsleinstrasse 15, Würzburg, 97080, Germany

    Andreas Reif

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Tarantino, L.M., Eisener-Dorman, A.F. (2011). Forward Genetic Approaches to Understanding Complex Behaviors. In: Cryan, J., Reif, A. (eds) Behavioral Neurogenetics. Current Topics in Behavioral Neurosciences, vol 12. Springer, Berlin, Heidelberg. https://doi.org/10.1007/7854_2011_189

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