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Behavioral Neurogenetics pp 537–577Cite as

Genetic Factors Modulating the Response to Stimulant Drugs in Humans

Part of the Current Topics in Behavioral Neurosciences book series (CTBN,volume 12)

Abstract

Individuals vary in their responses to stimulant drugs, and several lines of evidence suggest that the basis for this variation is at least partially genetic in origin. Association studies have examined the effects of polymorphisms in specific genes on acute and chronic responses to stimulant drugs. Several of these genetic polymorphisms are also associated with other psychiatric dimensions and disorders. This chapter examines the evidence for genetic associations between the genes that have been most carefully examined for their influence on the response to stimulant drugs.

Keywords

  • Stimulants
  • Inter-individual variation
  • Drug response
  • Candidate gene
  • Genetic association
  • Genetic polymorphism

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  • DOI: 10.1007/7854_2011_187
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Acknowledgements

This work was supported by NIH grants DA02812, DA027545 and DA021336.

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  1. Department of Human Genetics, University of Chicago, 920 E 58th St. CLSC-507D, Chicago, IL 60637, USA

    Amy B. Hart & Abraham A. Palmer

  2. Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL 60637, USA

    Harriet de Wit & Abraham A. Palmer

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  1. Amy B. Hart
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  1. , Dep of Pharmacology and Therapeutics, School of Pharmacy, College Rd, Cork, 30, Ireland

    John F. Cryan

  2. , Department of Psychiatry and Psychothera, University of Würzburg, Füchsleinstrasse 15, Würzburg, 97080, Germany

    Andreas Reif

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Hart, A.B., de Wit, H., Palmer, A.A. (2011). Genetic Factors Modulating the Response to Stimulant Drugs in Humans. In: Cryan, J., Reif, A. (eds) Behavioral Neurogenetics. Current Topics in Behavioral Neurosciences, vol 12. Springer, Berlin, Heidelberg. https://doi.org/10.1007/7854_2011_187

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