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Toward a Mechanistic Understanding of How Variability in Neurobiology Shapes Individual Differences in Behavior

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Book cover Behavioral Neurogenetics

Part of the book series: Current Topics in Behavioral Neurosciences ((CTBN,volume 12))

Abstract

Research has begun to identify how variability in brain function contributes to individual differences in complex behavioral traits. Examining variability in molecular signaling pathways with emerging and established methodologies such as pharmacologic fMRI, multimodal PET/fMRI, and hormonal assays are beginning to provide a mechanistic understanding of how individual differences in brain function arise. Against this background, functional genetic polymorphisms are being utilized to understand the origins of variability in signaling pathways as well as to efficiently model how such emergent variability impacts behaviorally relevant brain function and health outcomes. This chapter provides an overview of a research strategy that integrates these complimentary levels of analysis; existing empirical data is used to illustrate the effectiveness of this approach in illuminating the mechanistic neurobiology of individual differences in complex behavioral traits. This chapter also discusses how such efforts can contribute to the identification of predictive risk markers that interact with unique environmental factors to precipitate psychopathology.

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Acknowledgment

This manuscript is largely based on an earlier publication in the Annual Review of Neuroscience (Hariri 2009).

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Authors and Affiliations

  1. Laboratory of NeuroGenetics, Department of Psychology & Neuroscience, Institute for Genome Sciences & Policy, Duke University, 417 Chapel Drive, Durham, NC, 27708, USA

    Ryan Bogdan, Justin M. Carré & Ahmad R. Hariri

  2. Laboratory of Social Neuroendocrinology, Department of Psychology, Wayne State University, Detroit, MI, 48202, USA

    Justin M. Carré

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Correspondence to Ryan Bogdan .

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  1. , Dep of Pharmacology and Therapeutics, School of Pharmacy, College Rd, Cork, 30, Ireland

    John F. Cryan

  2. , Department of Psychiatry and Psychothera, University of Würzburg, Füchsleinstrasse 15, Würzburg, 97080, Germany

    Andreas Reif

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Bogdan, R., Carré, J.M., Hariri, A.R. (2011). Toward a Mechanistic Understanding of How Variability in Neurobiology Shapes Individual Differences in Behavior. In: Cryan, J., Reif, A. (eds) Behavioral Neurogenetics. Current Topics in Behavioral Neurosciences, vol 12. Springer, Berlin, Heidelberg. https://doi.org/10.1007/7854_2011_182

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