Skip to main content
SpringerLink
Log in
Book cover

Behavioral Neurobiology of Eating Disorders pp 209–227Cite as

Animal Models of Eating Disorder Traits

  • Chapter
  • First Online:

Part of the book series: Current Topics in Behavioral Neurosciences ((CTBN,volume 6))

Abstract

Eating disorders, such as anorexia and bulimia nervosa, are psychiatric disorders that are likely determined by a complex interaction between genetic variations, developmental processes, and certain life events. Cross-species analysis of traits related to eating disorders may provide a way to functionally and systematically study neurobiological mechanisms underlying these disorders. Interspecies trait genetics may offer opportunities to identify common neurobiological mechanisms underlying eating disorder characteristics relevant to the initiation, progression, and/or maintenance of the disease, such as cognitive rigidity, increased anxiety levels, and behavioral hyperactivity. These can subsequently be tested directly by studying allelic variation in mice and human subjects and by applying methods that can modify gene expression levels in rodent models. Increasing our knowledge about these traits and their underlying neurobiological mechanisms will be relevant to develop new therapies for patients within the heterogeneous eating disorder populations. Novel mouse genetic and phenotyping tools offer a way to study these neurobehavioral traits under controlled environmental and genetic background conditions.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  • Adan RA, Tiesjema B, Hillebrand JJ, la Fleur SE, Kas MJ, de Krom M (2006) The MC4 receptor and control of appetite. Br J Pharmacol 149:815–827

    CAS  PubMed  Google Scholar 

  • Barbarich-Marsteller NC, Marsteller DA, Alexoff DL, Fowler JS, Dewey SL (2005) MicroPET imaging in an animal model of anorexia nervosa. Synapse 57:85–90

    CAS  PubMed  Google Scholar 

  • Barbarich-Marsteller N, Pike K, Underwood M, Foltin R, Walsh B (2007) Vulnerability of activity-based anorexia in adolescent female rats. Abstr Annu Meet Eat Disord Res Soc P8

    Google Scholar 

  • Barsh GS, Farooqi IS, O'rahilly S (2000) Genetics of body-weight regulation. Nature 404:644–651

    CAS  PubMed  Google Scholar 

  • Bergen AW, Yeager M, Welch RA, Haque K, Ganjei JK, van den Bree MB, Mazzanti C, Nardi I, Fichter MM, Halmi KA, Kaplan AS, Strober M, Treasure J, Woodside DB, Bulik CM, Bacanu SA, Devlin B, Berrettini WH, Goldman D, Kaye WH (2005) Association of multiple DRD2 polymorphisms with anorexia nervosa. Neuropsychopharmacology 30:1703–1710

    CAS  PubMed  Google Scholar 

  • Bergh C, Sodersten P (1996) Anorexia nervosa, self-starvation and the reward of stress. Nat Med 2:21–22

    CAS  PubMed  Google Scholar 

  • Birrell JM, Brown VJ (2000) Medial frontal cortex mediates perceptual attentional set shifting in the rat. J Neurosci 20:4320–4324

    CAS  PubMed  Google Scholar 

  • Bissonette GB, Martins GJ, Franz TM, Harper ES, Schoenbaum G, Powell EM (2008) Double dissociation of the effects of medial and orbital prefrontal cortical lesions on attentional and affective shifts in mice. J Neurosci 28:11124–11130

    CAS  PubMed  Google Scholar 

  • Blum K, Sheridan PJ, Wood RC, Braverman ER, Chen TJ, Comings DE (1995) Dopamine D2 receptor gene variants: association and linkage studies in impulsive-addictive-compulsive behaviour. Pharmacogenetics 5:121–141

    CAS  PubMed  Google Scholar 

  • Brewerton TD, Lydiard RB, Herzog DB, Brotman AW, O'Neil PM, Ballenger JC (1995a) Comorbidity of axis I psychiatric disorders in bulimia nervosa. J Clin Psychiatry 56:77–80

    CAS  PubMed  Google Scholar 

  • Brewerton TD, Stellefson EJ, Hibbs N, Hodges EL, Cochrane CE (1995b) Comparison of eating disorder patients with and without compulsive exercising. Int J Eat Disord 17:413–416

    CAS  PubMed  Google Scholar 

  • Brigman JL, Bussey TJ, Saksida LM, Rothblat LA (2005) Discrimination of multidimensional visual stimuli by mice: intra- and extradimensional shifts. Behav Neurosci 119:839–842

    PubMed  Google Scholar 

  • Brooks SP, Betteridge H, Trueman RC, Jones L, Dunnett SB (2006) Selective extra-dimensional set shifting deficit in a knock-in mouse model of Huntington's disease. Brain Res Bull 69:452–457

    CAS  PubMed  Google Scholar 

  • Buettner R, Scholmerich J, Bollheimer LC (2007) High-fat diets: modeling the metabolic disorders of human obesity in rodents. Obesity (Silver Spring) 15:798–808

    CAS  Google Scholar 

  • Bulik CM (2002) Eating disorders in adolescents and young adults. Child Adolesc Psychiatr Clin N Am 11:201–218

    PubMed  Google Scholar 

  • Bulik CM, Sullivan PF, Fear JL, Joyce PR (1997) Eating disorders and antecedent anxiety disorders: a controlled study. Acta Psychiatr Scand 96:101–107

    CAS  PubMed  Google Scholar 

  • Bulik CM, Hebebrand J, Keski-Rahkonen A, Klump KL, Reichborn-Kjennerud T, Mazzeo SE, Wade TD (2007a) Genetic epidemiology, endophenotypes, and eating disorder classification. Int J Eat Disord 40(Suppl):S52–S60

    PubMed  Google Scholar 

  • Bulik CM, Slof-Op't Landt MC, van Furth EF, Sullivan PF (2007b) The genetics of anorexia nervosa. Annu Rev Nutr 27:263–275

    CAS  PubMed  Google Scholar 

  • Carter FA, McIntosh VV, Joyce PR, Gendall KA, Frampton CM, Bulik CM (2004) Patterns of weight change after treatment for bulimia nervosa. Int J Eat Disord 36:12–21

    PubMed  Google Scholar 

  • Chen ZY, Jing D, Bath KG, Ieraci A, Khan T, Siao CJ, Herrera DG, Toth M, Yang C, McEwen BS, Hempstead BL, Lee FS (2006) Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior. Science 314:140–143

    CAS  PubMed  Google Scholar 

  • Cryan JF, Holmes A (2005) The ascent of mouse: advances in modelling human depression and anxiety. Nat Rev Drug Discov 4:775–790

    CAS  PubMed  Google Scholar 

  • Cryan JF, Mombereau C (2004) In search of a depressed mouse: utility of models for studying depression-related behavior in genetically modified mice. Mol Psychiatry 9:326–357

    CAS  PubMed  Google Scholar 

  • Cunningham CL, Howard MA, Gill SJ, Rubinstein M, Low MJ, Grandy DK (2000) Ethanol-conditioned place preference is reduced in dopamine D2 receptor-deficient mice. Pharmacol Biochem Behav 67:693–699

    CAS  PubMed  Google Scholar 

  • Davis C, Katzman DK, Kaptein S, Kirsh C, Brewer H, Kalmbach K, Olmsted MP, Woodside DB, Kaplan AS (1997) The prevalence of high-level exercise in the eating disorders: etiological implications. Compr Psychiatry 38:321–326

    CAS  PubMed  Google Scholar 

  • Davis C, Katzman DK, Kirsh C (1999) Compulsive physical activity in adolescents with anorexia nervosa: a psychobehavioral spiral of pathology. J Nerv Ment Dis 187:336–342

    CAS  PubMed  Google Scholar 

  • de Mooij-van Malsen AJ, van Lith HA, Oppelaar H, Hendriks J, de Wit M, Kostrzewa E, Breen G, Collier DA, Olivier B, Kas MJ (2009) Interspecies trait genetics reveals association of Adcy8 with mouse avoidance behavior and a human mood disorder. Biol Psychiatry 66:1123–1130

    PubMed  Google Scholar 

  • Deep AL, Nagy LM, Weltzin TE, Rao R, Kaye WH (1995) Premorbid onset of psychopathology in long-term recovered anorexia nervosa. Int J Eat Disord 17:291–297

    CAS  PubMed  Google Scholar 

  • Dennis C (2005) Psychiatric disease: all in the mind of a mouse. Nature 438:151–152

    CAS  PubMed  Google Scholar 

  • Dranovsky A, Hen R (2006) Hippocampal neurogenesis: regulation by stress and antidepressants. Biol Psychiatry 59:1136–1143

    CAS  PubMed  Google Scholar 

  • Drew MR, Simpson EH, Kellendonk C, Herzberg WG, Lipatova O, Fairhurst S, Kandel ER, Malapani C, Balsam PD (2007) Transient overexpression of striatal D2 receptors impairs operant motivation and interval timing. J Neurosci 27:7731–7739

    CAS  PubMed  Google Scholar 

  • Egan MF, Kojima M, Callicott JH, Goldberg TE, Kolachana BS, Bertolino A, Zaitsev E, Gold B, Goldman D, Dean M, Lu B, Weinberger DR (2003) The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell 112:257–269

    CAS  PubMed  Google Scholar 

  • Elmer GI, Pieper JO, Rubinstein M, Low MJ, Grandy DK, Wise RA (2002) Failure of intravenous morphine to serve as an effective instrumental reinforcer in dopamine D2 receptor knock-out mice. J Neurosci 22:RC224

    PubMed  Google Scholar 

  • Evenden J (1999) Impulsivity: a discussion of clinical and experimental findings. J Psychopharmacol 13:180–192

    CAS  PubMed  Google Scholar 

  • Exner C, Hebebrand J, Remschmidt H, Wewetzer C, Ziegler A, Herpertz S, Schweiger U, Blum WF, Preibisch G, Heldmaier G, Klingenspor M (2000) Leptin suppresses semi-starvation induced hyperactivity in rats: implications for anorexia nervosa. Mol Psychiatry 5:476–481

    CAS  PubMed  Google Scholar 

  • Fairburn CG, Harrison PJ (2003) Eating disorders. Lancet 361:407–416

    PubMed  Google Scholar 

  • Fernandes C, Paya-Cano JL, Sluyter F, D'Souza U, Plomin R, Schalkwyk LC (2004) Hippocampal gene expression profiling across eight mouse inbred strains: towards understanding the molecular basis for behaviour. Eur J Neurosci 19:2576–2582

    PubMed  Google Scholar 

  • Fornari V, Wlodarczyk-Bisaga K, Matthews M, Sandberg D, Mandel FS, Katz JL (1999) Perception of family functioning and depressive symptomatology in individuals with anorexia nervosa or bulimia nervosa. Compr Psychiatry 40:434–441

    CAS  PubMed  Google Scholar 

  • Frank GK, Bailer UF, Henry SE, Drevets W, Meltzer CC, Price JC, Mathis CA, Wagner A, Hoge J, Ziolko S, Barbarich-Marsteller N, Weissfeld L, Kaye WH (2005) Increased dopamine D2/D3 receptor binding after recovery from anorexia nervosa measured by positron emission tomography and [11c]raclopride. Biol Psychiatry 58:908–912

    CAS  PubMed  Google Scholar 

  • Frazer KA, Eskin E, Kang HM, Bogue MA, Hinds DA, Beilharz EJ, Gupta RV, Montgomery J, Morenzoni MM, Nilsen GB, Pethiyagoda CL, Stuve LL, Johnson FM, Daly MJ, Wade CM, Cox DR (2007) A sequence-based variation map of 8.27 million SNPs in inbred mouse strains. Nature 448:1050–1053

    CAS  PubMed  Google Scholar 

  • Friederich HC, Kumari V, Uher R, Riga M, Schmidt U, Campbell IC, Herzog W, Treasure J (2006) Differential motivational responses to food and pleasurable cues in anorexia and bulimia nervosa: a startle reflex paradigm. Psychol Med 36:1327–1335

    PubMed  Google Scholar 

  • Gelegen C, Collier DA, Campbell IC, Oppelaar H, van den HJ A, RA KMJ (2007) Difference in susceptibility to activity-based anorexia in two inbred strains of mice. Eur Neuropsychopharmacol 17:199–205

    CAS  PubMed  Google Scholar 

  • Gelegen C, van den Heuvel J, Collier DA, Campbell IC, Oppelaar H, Hessel E, Kas MJ (2008) Dopaminergic and BDNF signalling in inbred mice exposed to a restricted feeding schedule. Genes Brain Behav 7:552–559

    CAS  PubMed  Google Scholar 

  • Gelegen C, Pjetri E, Campbell IC, Collier DA, Oppelaar H, Kas MJ (2010) Chromosomal mapping of excessive physical activity in mice in response to a restricted feeding schedule. Eur Neuropsychopharmacol 20(5): 317–326

    Google Scholar 

  • Godart NT, Flament MF, Perdereau F, Jeammet P (2002) Comorbidity between eating disorders and anxiety disorders: a review. Int J Eat Disord 32:253–270

    CAS  PubMed  Google Scholar 

  • Godart NT, Flament MF, Curt F, Perdereau F, Lang F, Venisse JL, Halfon O, Bizouard P, Loas G, Corcos M, Jeammet P, Fermanian J (2003) Anxiety disorders in subjects seeking treatment for eating disorders: a DSM-IV controlled study. Psychiatry Res 117:245–258

    PubMed  Google Scholar 

  • Godart N, Berthoz S, Perdereau F, Jeammet P (2006) Comorbidity of anxiety with eating disorders and OCD. Am J Psychiatry 163:326–329

    PubMed  Google Scholar 

  • Gottesman II, Gould TD (2003) The endophenotype concept in psychiatry: etymology and strategic intentions. Am J Psychiatry 160:636–645

    PubMed  Google Scholar 

  • Grice DE, Halmi KA, Fichter MM, Strober M, Woodside DB, Treasure JT, Kaplan AS, Magistretti PJ, Goldman D, Bulik CM, Kaye WH, Berrettini WH (2002) Evidence for a susceptibility gene for anorexia nervosa on chromosome 1. Am J Hum Genet 70:787–792

    CAS  PubMed  Google Scholar 

  • Gross C, Zhuang X, Stark K, Ramboz S, Oosting R, Kirby L, Santarelli L, Beck S, Hen R (2002) Serotonin1A receptor acts during development to establish normal anxiety-like behaviour in the adult. Nature 416:396–400

    CAS  PubMed  Google Scholar 

  • Grupe A, Germer S, Usuka J, Aud D, Belknap JK, Klein RF, Ahluwalia MK, Higuchi R, Peltz G (2001) In silico mapping of complex disease-related traits in mice. Science 292:1915–1918

    CAS  PubMed  Google Scholar 

  • Hall CS (1936) Emotional behavior in the rat. III The relationship between emotionality and ambulatory activity. J Comp Psychol 22:345–352

    Google Scholar 

  • Halmi KA, Sunday SR, Klump KL, Strober M, Leckman JF, Fichter M, Kaplan A, Woodside B, Treasure J, Berrettini WH, Al Shabboat M, Bulik CM, Kaye WH (2003) Obsessions and compulsions in anorexia nervosa subtypes. Int J Eat Disord 33:308–319

    PubMed  Google Scholar 

  • Hebebrand J, Exner C, Hebebrand K, Holtkamp C, Casper RC, Remschmidt H, Herpertz-Dahlmann B, Klingenspor M (2003) Hyperactivity in patients with anorexia nervosa and in semistarved rats: evidence for a pivotal role of hypoleptinemia. Physiol Behav 79:25–37

    CAS  PubMed  Google Scholar 

  • Herzog DB, Dorer DJ, Keel PK, Selwyn SE, Ekeblad ER, Flores AT, Greenwood DN, Burwell RA, Keller MB (1999) Recovery and relapse in anorexia and bulimia nervosa: a 7.5-year follow-up study. J Am Acad Child Adolesc Psychiatry 38:829–837

    CAS  PubMed  Google Scholar 

  • Hillebrand JJ, Koeners MP, de Rijke CE, Kas MJ, Adan RA (2005a) Leptin treatment in activity-based anorexia. Biol Psychiatry 58:165–171

    CAS  PubMed  Google Scholar 

  • Hillebrand JJ, van Elburg AA, Kas MJ, van Engeland H, Adan RA (2005b) Olanzapine reduces physical activity in rats exposed to activity-based anorexia: possible implications for treatment of anorexia nervosa? Biol Psychiatry 58:651–657

    CAS  PubMed  Google Scholar 

  • Hinney A, Remschmidt H, Hebebrand J (2000) Candidate gene polymorphisms in eating disorders. Eur J Pharmacol 410:147–159

    CAS  PubMed  Google Scholar 

  • Hoek HW (2006) Incidence, prevalence and mortality of anorexia nervosa and other eating disorders. Curr Opin Psychiatry 19:389–394

    PubMed  Google Scholar 

  • Holliday J, Tchanturia K, Landau S, Collier D, Treasure J (2005) Is impaired set-shifting an endophenotype of anorexia nervosa? Am J Psychiatry 162:2269–2275

    PubMed  Google Scholar 

  • Holtkamp K, Herpertz-Dahlmann B, Mika C, Heer M, Heussen N, Fichter M, Herpertz S, Senf W, Blum WF, Schweiger U, Warnke A, Ballauff A, Remschmidt H, Hebebrand J (2003) Elevated physical activity and low leptin levels co-occur in patients with anorexia nervosa. J Clin Endocrinol Metab 88:5169–5174

    CAS  PubMed  Google Scholar 

  • Holtkamp K, Hebebrand J, Herpertz-Dahlmann B (2004) The contribution of anxiety and food restriction on physical activity levels in acute anorexia nervosa. Int J Eat Disord 36:163–171

    PubMed  Google Scholar 

  • Hovatta I, Zapala MA, Broide RS, Schadt EE, Libiger O, Schork NJ, Lockhart DJ, Barlow C (2007) DNA variation and brain region-specific expression profiles exhibit different relationships between inbred mouse strains: implications for eQTL mapping studies. Genome Biol 8:R25

    PubMed  Google Scholar 

  • Jansen RC, Nap JP (2001) Genetical genomics: the added value from segregation. Trends Genet 17:388–391

    CAS  PubMed  Google Scholar 

  • Jentsch JD, Taylor JR (1999) Impulsivity resulting from frontostriatal dysfunction in drug abuse: implications for the control of behavior by reward-related stimuli. Psychopharmacology (Berl) 146:373–390

    CAS  Google Scholar 

  • Joel D (2006) Current animal models of obsessive compulsive disorder: a critical review. Prog Neuropsychopharmacol Biol Psychiatry 30:374–388

    PubMed  Google Scholar 

  • Kas MJ, Van Ree JM (2004) Dissecting complex behaviours in the post-genomic era. Trends Neurosci 27:366–369

    CAS  PubMed  Google Scholar 

  • Kas MJ, van Dijk G, Scheurink AJ, Adan RA (2003a) Agouti-related protein prevents self-starvation. Mol Psychiatry 8:235–240

    CAS  PubMed  Google Scholar 

  • Kas MJ, van Elburg AA, van Engeland H, Adan RA (2003b) Refinement of behavioural traits in animals for the genetic dissection of eating disorders. Eur J Pharmacol 480:13–20

    CAS  PubMed  Google Scholar 

  • Kas MJ, Fernandes C, Schalkwyk LC, Collier DA (2007) Genetics of behavioural domains across the neuropsychiatric spectrum; of mice and men. Mol Psychiatry 12:324–330

    CAS  PubMed  Google Scholar 

  • Kas MJ, de Mooij-van Malsen JG, Olivier B, Spruijt BM, Van Ree JM (2008) Differential genetic regulation of motor activity and anxiety-related behaviors in mice using an automated home cage task. Behav Neurosci 122(4):769–76

    Google Scholar 

  • Kas MJ, Kaye WH, Foulds MW, Bulik CM (2009) Interspecies genetics of eating disorder traits. Am J Med Genet B Neuropsychiatr Genet 150B:318–327

    CAS  PubMed  Google Scholar 

  • Kas MJ, Gelegen C, van Nieuwerburgh F, Westenberg HG, Deforce D, Denys D (2010) Compulsivity in mouse strains homologous with chromosomes 7p and 15q linked to obsessive-compulsive disorder. Am J Med Genet B Neuropsychiatr Genet 153B:252–259

    PubMed  Google Scholar 

  • Kaye WH, Bulik CM, Thornton L, Barbarich N, Masters K (2004) Comorbidity of anxiety disorders with anorexia and bulimia nervosa. Am J Psychiatry 161:2215–2221

    PubMed  Google Scholar 

  • Kaye WH, Fudge JL, Paulus M (2009) New insights into symptoms and neurocircuit function of anorexia nervosa. Nat Rev Neurosci 10:573–584

    CAS  PubMed  Google Scholar 

  • Keck P, Pope H, Hudson JL, McElroy S, Yurgelung-Todd D, Hundert E (1990) A controlled study of phenomenology and family history in outpatients with bulimia nervosa. Compr Psychiatry 31:275–283

    PubMed  Google Scholar 

  • Keski-Rahkonen A, Neale BM, Bulik CM, Pietilainen KH, Rose RJ, Kaprio J, Rissanen A (2005) Intentional weight loss in young adults: sex-specific genetic and environmental effects. Obes Res 13:745–753

    PubMed  Google Scholar 

  • Klump KL, Gobrogge KL (2005) A review and primer of molecular genetic studies of anorexia nervosa. Int J Eat Disord 37(Suppl):S43–S48

    PubMed  Google Scholar 

  • Korff S, Harvey BH (2006) Animal models of obsessive-compulsive disorder: rationale to understanding psychobiology and pharmacology. Psychiatr Clin North Am 29:371–390

    PubMed  Google Scholar 

  • Laessle RG, Beumont PJ, Butow P, Lennerts W, O'Connor M, Pirke KM, Touyz SW, Waadt S (1991) A comparison of nutritional management with stress management in the treatment of bulimia nervosa. Br J Psychiatry 159:250–261

    CAS  PubMed  Google Scholar 

  • Lang UE, Hellweg R, Kalus P, Bajbouj M, Lenzen KP, Sander T, Kunz D, Gallinat J (2005) Association of a functional BDNF polymorphism and anxiety-related personality traits. Psychopharmacology (Berl) 180:95–99

    CAS  Google Scholar 

  • Lesch KP, Merschdorf U (2000) Impulsivity, aggression, and serotonin: a molecular psychobiological perspective. Behav Sci Law 18:581–604

    CAS  PubMed  Google Scholar 

  • Letwin NE, Kafkafi N, Benjamini Y, Mayo C, Frank BC, Luu T, Lee NH, Elmer GI (2006) Combined application of behavior genetics and microarray analysis to identify regional expression themes and gene-behavior associations. J Neurosci 26:5277–5287

    CAS  PubMed  Google Scholar 

  • Lohoff FW, Sander T, Ferraro TN, Dahl JP, Gallinat J, Berrettini WH (2005) Confirmation of association between the Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) gene and bipolar I disorder. Am J Med Genet B Neuropsychiatr Genet 139:51–53

    Google Scholar 

  • Maldonado R, Saiardi A, Valverde O, Samad TA, Roques BP, Borrelli E (1997) Absence of opiate rewarding effects in mice lacking dopamine D2 receptors. Nature 388:586–589

    CAS  PubMed  Google Scholar 

  • Mazzeo SE, Slof-Op't Landt MC, Jones I, Mitchell K, Kendler KS, Neale MC, Aggen SH, Bulik CM (2006) Associations among postpartum depression, eating disorders, and perfectionism in a population-based sample of adult women. Int J Eat Disord 39:202–211

    PubMed  Google Scholar 

  • Mazzeo SE, Mitchell KS, Bulik CM, Reichborn-Kjennerud T, Kendler KS, Neale MC (2009) Assessing the heritability of anorexia nervosa symptoms using a marginal maximal likelihood approach. Psychol Med 39:463–473

    CAS  PubMed  Google Scholar 

  • Mercer JG, Tups A (2003) Neuropeptides and anticipatory changes in behaviour and physiology: seasonal body weight regulation in the Siberian hamster. Eur J Pharmacol 480:43–50

    CAS  PubMed  Google Scholar 

  • Moy SS, Nadler JJ, Young NB, Perez A, Holloway LP, Barbaro RP, Barbaro JR, Wilson LM, Threadgill DW, Lauder JM, Magnuson TR, Crawley JN (2007) Mouse behavioral tasks relevant to autism: phenotypes of 10 inbred strains. Behav Brain Res 176:4–20

    PubMed  Google Scholar 

  • Nadler JJ, Moy SS, Dold G, Trang D, Simmons N, Perez A, Young NB, Barbaro RP, Piven J, Magnuson TR, Crawley JN (2004) Automated apparatus for quantitation of social approach behaviors in mice. Genes Brain Behav 3:303–314

    CAS  PubMed  Google Scholar 

  • Nestler EJ, Gould E, Manji H, Buncan M, Duman RS, Greshenfeld HK, Hen R, Koester S, Lederhendler I, Meaney M, Robbins T, Winsky L, Zalcman S (2002) Preclinical models: status of basic research in depression. Biol Psychiatry 52:503–528

    PubMed  Google Scholar 

  • Neves-Pereira M, Cheung JK, Pasdar A, Zhang F, Breen G, Yates P, Sinclair M, Crombie C, Walker N, St Clair DM (2005) BDNF gene is a risk factor for schizophrenia in a Scottish population. Mol Psychiatry 10:208–212

    CAS  PubMed  Google Scholar 

  • Nisoli E, Brunani A, Borgomainerio E, Tonello C, Dioni L, Briscini L, Redaelli G, Molinari E, Cavagnini F, Carruba MO (2007) D2 dopamine receptor (DRD2) gene Taq1A polymorphism and the eating-related psychological traits in eating disorders (anorexia nervosa and bulimia) and obesity. Eat Weight Disord 12:91–96

    CAS  PubMed  Google Scholar 

  • Plomin R, McClearn GE, Gora-Maslak G, Neiderhiser JM (1991) Use of recombinant inbred strains to detect quantitative trait loci associated with behavior. Behav Genet 21:99–116

    CAS  PubMed  Google Scholar 

  • Redei EE, Ahmadiyeh N, Baum AE, Sasso DA, Slone JL, Solberg LC, Will CC, Volenec A (2001) Novel animal models of affective disorders. Semin Clin Neuropsychiatry 6:43–67

    CAS  PubMed  Google Scholar 

  • Ribases M, Gratacos M, Fernandez-Aranda F, Bellodi L, Boni C, Anderluh M, Cavallini MC, Cellini E, Di Bella D, Erzegovesi S, Foulon C, Gabrovsek M, Gorwood P, Hebebrand J, Hinney A, Holliday J, Hu X, Karwautz A, Kipman A, Komel R, Nacmias B, Remschmidt H, Ricca V, Sorbi S, Wagner G, Treasure J, Collier DA, Estivill X (2004) Association of BDNF with anorexia, bulimia and age of onset of weight loss in six European populations. Hum Mol Genet 13:1205–1212

    CAS  PubMed  Google Scholar 

  • Ribases M, Gratacos M, Fernandez-Aranda F, Bellodi L, Boni C, Anderluh M, Cristina CM, Cellini E, Di Bella D, Erzegovesi S, Foulon C, Gabrovsek M, Gorwood P, Hebebrand J, Hinney A, Holliday J, Hu X, Karwautz A, Kipman A, Komel R, Nacmias B, Remschmidt H, Ricca V, Sorbi S, Tomori M, Wagner G, Treasure J, Collier DA, Estivill X (2005) Association of BDNF with restricting anorexia nervosa and minimum body mass index: a family-based association study of eight European populations. Eur J Hum Genet 13:428–434

    CAS  PubMed  Google Scholar 

  • Rohner-Jeanrenaud E, Jeanrenaud B (1997) Central nervous system and body weight regulation. Ann Endocrinol (Paris) 58:137–142

    CAS  Google Scholar 

  • Routtenberg A, Kuznesof AW (1967) Self-starvation of rats living in activity wheels on a restricted feeding schedule. J Comp Physiol Psychol 64:414–421

    CAS  PubMed  Google Scholar 

  • Sandberg R, Yasuda R, Pankratz DG, Carter TA, Del Rio JA, Wodicka L, Mayford M, Lockhart DJ, Barlow C (2000) Regional and strain-specific gene expression mapping in the adult mouse brain. Proc Natl Acad Sci USA 97:11038–11043

    CAS  PubMed  Google Scholar 

  • Schumacher J, Jamra RA, Becker T, Ohlraun S, Klopp N, Binder EB, Schulze TG, Deschner M, Schmal C, Hofels S, Zobel A, Illig T, Propping P, Holsboer F, Rietschel M, Nothen MM, Cichon S (2005) Evidence for a relationship between genetic variants at the brain-derived neurotrophic factor (BDNF) locus and major depression. Biol Psychiatry 58:307–314

    CAS  PubMed  Google Scholar 

  • Schwalberg MD, Barlow DH, Alger SA, Howard LJ (1992) Comparison of bulimics, obese binge eaters, social phobics, and individuals with panic disorder on comorbidity across DSM-III-R anxiety disorders. J Abnorm Psychol 101:675–681

    CAS  PubMed  Google Scholar 

  • Shugart YY, Samuels J, Willour VL, Grados MA, Greenberg BD, Knowles JA, McCracken JT, Rauch SL, Murphy DL, Wang Y, Pinto A, Fyer AJ, Piacentini J, Pauls DL, Cullen B, Page J, Rasmussen SA, Bienvenu OJ, Hoehn-Saric R, Valle D, Liang KY, Riddle MA, Nestadt G (2006) Genomewide linkage scan for obsessive-compulsive disorder: evidence for susceptibility loci on chromosomes 3q, 7p, 1q, 15q, and 6q. Mol Psychiatry 11:763–770

    CAS  PubMed  Google Scholar 

  • Siegfried Z, Berry EM, Hao S, Avraham Y (2003) Animal models in the investigation of anorexia. Physiol Behav 79:39–45

    CAS  PubMed  Google Scholar 

  • Singer JB, Hill AE, Burrage LC, Olszens KR, Song J, Justice M, O'Brien WE, Conti DV, Witte JS, Lander ES, Nadeau JH (2004) Genetic dissection of complex traits with chromosome substitution strains of mice. Science 304:445–448

    CAS  PubMed  Google Scholar 

  • Swinbourne JM, Touyz SW (2007) The co-morbidity of eating disorders and anxiety disorders: a review. Eur Eat Disord Rev 15:253–274

    PubMed  Google Scholar 

  • Tchanturia K, Morris RG, Anderluh MB, Collier DA, Nikolaou V, Treasure J (2004) Set shifting in anorexia nervosa: an examination before and after weight gain, in full recovery and relationship to childhood and adult OCPD traits. J Psychiatr Res 38:545–552

    CAS  PubMed  Google Scholar 

  • Toner BB, Garfinkel PE, Garner DM (1988) Affective and anxiety disorders in the long-term follow-up of anorexia nervosa. Int J Psychiatry Med 18:357–364

    CAS  PubMed  Google Scholar 

  • Tran AH, Tamura R, Uwano T, Kobayashi T, Katsuki M, Matsumoto G, Ono T (2002) Altered accumbens neural response to prediction of reward associated with place in dopamine D2 receptor knockout mice. Proc Natl Acad Sci USA 99:8986–8991

    CAS  PubMed  Google Scholar 

  • Treasure J, Claudino AM, Zucker N (2010) Eating disorders. Lancet 375(9714):583–593

    Google Scholar 

  • van Elburg AA, Kas MJ, Hillebrand JJ, Eijkemans RJ, van Engeland H (2007) The impact of hyperactivity and leptin on recovery from anorexia nervosa. J Neural Transm 114:1233–1237

    PubMed  Google Scholar 

  • van Kuyck K, Casteels C, Vermaelen P, Bormans G, Nuttin B, Van Laere K (2007) Motor- and food-related metabolic cerebral changes in the activity-based rat model for anorexia nervosa: a voxel-based microPET study. Neuroimage 35:214–221

    PubMed  Google Scholar 

  • Wade CM, Daly MJ (2005) Genetic variation in laboratory mice. Nat Genet 37:1175–1180

    CAS  PubMed  Google Scholar 

  • Wade CM, Kulbokas EJ III, Kirby AW, Zody MC, Mullikin JC, Lander ES, Lindblad-Toh K, Daly MJ (2002) The mosaic structure of variation in the laboratory mouse genome. Nature 420:574–578

    CAS  PubMed  Google Scholar 

  • Wagner A, Aizenstein H, Venkatraman VK, Fudge J, May JC, Mazurkewicz L, Frank GK, Bailer UF, Fischer L, Nguyen V, Carter C, Putnam K, Kaye WH (2007) Altered reward processing in women recovered from anorexia nervosa. Am J Psychiatry 164:1842–1849

    PubMed  Google Scholar 

  • Yalcin B, Willis-Owen SA, Fullerton J, Meesaq A, Deacon RM, Rawlins JN, Copley RR, Morris AP, Flint J, Mott R (2004) Genetic dissection of a behavioral quantitative trait locus shows that Rgs2 modulates anxiety in mice. Nat Genet 36:1197–1202

    CAS  PubMed  Google Scholar 

  • Yang H, Bell TA, Churchill GA, Pardo-Manuel dV (2007) On the subspecific origin of the laboratory mouse. Nat Genet 39:1100–1107

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, The Netherlands

    Martien J. H. Kas & Roger A. H. Adan

Authors
  1. Martien J. H. Kas
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Roger A. H. Adan
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Martien J. H. Kas .

Editor information

Editors and Affiliations

  1. Neuroscience, Dept. Pharmacology, Rudolf Magnus Institute of, Universiteitsweg 100, Utrecht, 3508 AB, Netherlands

    Roger A.H. Adan

  2. Dept. Psychiatry, University of California, San Diego, La Jolla Drive 8950, La Jolla, 92037, California, USA

    Walter H. Kaye

Rights and permissions

Reprints and permissions

Copyright information

© 2010 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Kas, M.J.H., Adan, R.A.H. (2010). Animal Models of Eating Disorder Traits. In: Adan, R., Kaye, W. (eds) Behavioral Neurobiology of Eating Disorders. Current Topics in Behavioral Neurosciences, vol 6. Springer, Berlin, Heidelberg. https://doi.org/10.1007/7854_2010_84

Download citation

Publish with us

Policies and ethics

Search

Navigation