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Fluorescent Imaging in Medicinal Chemistry pp 125–148Cite as

X-Ray Excited Fluorescent Materials for Medical Application

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Part of the book series: Topics in Medicinal Chemistry ((TMC,volume 34))

Abstract

X-ray fluorescence (XF) and X-ray luminescence (XL) are X-ray stimulated processes which can be exploited for medical imaging. In recent years, the computed tomography (XFCT and XLCT) imaging of these processes has attracted much attention especially in the field of radiation therapy. These imaging modalities have potentials to offer additional functional information from the patient during exposure to X-rays for position alignment before the radiation treatment. More recently, these new techniques have been further studied in Monte Carlo simulations and benchtop experiments to characterize and optimize different imaging configurations. This chapter summarizes recent instrumentational developments in X-ray excited imaging; discusses their attributes, advantages, and drawbacks; and describes specifications and applications of various contrast agents for XF- and XLCT. The feasibility of the modalities for future clinical applications will be also highlighted.

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Acknowledgments

The authors would like to thank the NIH for the support of several XFCT and XLCT research projects and to the many researches who were involved in the related work at our institute.

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Authors and Affiliations

  1. Department of Radiation Oncology, Stanford University, School of Medicine, Stanford, CA, USA

    Don Vernekohl & Lei Xing

Authors
  1. Don Vernekohl
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  2. Lei Xing
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Editors and Affiliations

  1. Stanford University, Stanford, CA, USA

    Zhen Cheng

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Conflict of Interest

Author Don Vernekohl declares that he has no conflict of interest. Author Lei Xing declares that he has no conflict of interest.

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This article does not contain any studies with human participants or animals performed by any of the authors.

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Vernekohl, D., Xing, L. (2019). X-Ray Excited Fluorescent Materials for Medical Application. In: Cheng, Z. (eds) Fluorescent Imaging in Medicinal Chemistry . Topics in Medicinal Chemistry, vol 34. Springer, Cham. https://doi.org/10.1007/7355_2019_91

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