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Organic Fluorescent Probes for Diagnostics and Bio-Imaging

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Fluorescent Imaging in Medicinal Chemistry

Part of the book series: Topics in Medicinal Chemistry ((TMC,volume 34))

Abstract

Fluorescence bio-imaging holds potential for new approaches for disease detection and diagnosis. Compared with conventional clinical contrast imaging modalities, such as X-ray and MRI, which use contrast agents that are “always on,” fluorescence imaging contrast agents can readily be designed to be activatable under specific circumstances and also can be used in multiplexed imaging schemes. While a wide variety of fluorescence imaging probes have been developed, small organic fluorescence probes have the advantages of being robustly synthesized and characterized, as well as a track record for clinical translation. In this chapter, we discuss organic fluorophores and highlighted some examples of their biological applications. The aim of this chapter is to provide a literature review of the development of organic fluorescent probes for biomedical imaging and diagnosis.

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Acknowledgments

We thank the Tianjin University Start-up Funding and the Chinese One-thousand Young Talent Funding.

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Authors and Affiliations

  1. School of Chemical Engineering and Technology, Tianjin University, Tianjin, China

    Xingyue Yang & Yumiao Zhang

  2. Department of Biomedical Engineering, State University of New York at Buffalo, Buffalo, NY, USA

    Jonathan F. Lovell

  3. Department of Bioengineering, University of California, Berkeley, CA, USA

    Niren Murthy & Yumiao Zhang

Authors
  1. Xingyue Yang
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  2. Jonathan F. Lovell
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  3. Niren Murthy
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  4. Yumiao Zhang
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Corresponding author

Correspondence to Yumiao Zhang .

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Editors and Affiliations

  1. Stanford University, Stanford, CA, USA

    Zhen Cheng

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This chapter was made possible by Tianjin University Start-up Funding.

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The authors declare no conflict of interest.

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This chapter does not contain any studies with human participants or animals performed by any of the authors.

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Yang, X., Lovell, J.F., Murthy, N., Zhang, Y. (2019). Organic Fluorescent Probes for Diagnostics and Bio-Imaging. In: Cheng, Z. (eds) Fluorescent Imaging in Medicinal Chemistry . Topics in Medicinal Chemistry, vol 34. Springer, Cham. https://doi.org/10.1007/7355_2019_88

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