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Rational Design of Multifunctional Nanoscale Self-Assembled Soft Materials for Biomedical Delivery Application

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Personalized Medicine with a Nanochemistry Twist

Part of the book series: Topics in Medicinal Chemistry ((TMC,volume 20))

Abstract

Soft matter-based self-assembled nanostructures are promising for therapeutic delivery. Recent advances in synthetic polymerisation chemistries and reactive orthogonal functionalisation strategies have enabled straightforward access to well-defined nanostructures with precise control over numerous physico-chemical properties. Ability to integrate multiple components such as imaging/contrast agent, targeting ligand and smart components on to a nanocarrier has opened up innumerable possibilities in biomedical delivery application. In this chapter, key principles in the design of multifunctional nanocarriers and the challenges with clinical translation will be presented.

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Abbreviations

ADME:

Adsorption, distribution, metabolism and excretion

API:

Active pharmaceutical ingredient

ATRP:

Atom transfer radical polymerisation

CAC:

Critical aggregation concentration

CMC:

Critical micellisation concentration

CRP:

Controlled radical polymerisation

DLS:

Dynamic light scattering

DNA:

Deoxyribonucleic acid

EPR:

Enhanced permeation and retention

FDA:

Food and Drug Administration

LCST:

Lower critical solution temperature

mPEG:

Poly(ethylene glycol) methyl ether

NME:

New molecular entity

NMR:

Nuclear magnetic resonance

NMRP:

Nitroxide-mediated radical polymerisation

OC:

Organo-catalytic

PD:

Pharmacodynamics

PDI:

Polydispersity index

PEG:

Poly(ethylene glycol)

PK:

Pharmacokinetics

Ppm:

Parts per million

R&D:

Research and development

RAFT:

Reversible addition-fragmentation chain transfer

RES:

Reticuloendothelial system

RNA:

Ribonucleic acid

ROP:

Ring-opening polymerisation

ROS:

Reactive oxygen species

SANS:

Small-angle neutron scattering

SAXS:

Small-angle X-ray scattering

SCFT:

Self-consistent field theory

SEC:

Size-exclusion chromatography

siRNA:

Small interfering ribonucleic acid

TEM:

Transmission electron microscopy

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Acknowledgements

This work was funded by the Institute of Bioengineering and Nanotechnology (Biomedical Research Council, Agency for Science, Technology and Research, Singapore). Dr. Yi Yan Yang’s support for this work is greatly appreciated.

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Authors and Affiliations

  1. Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, The Nanos, Singapore, 138669, Singapore

    Shrinivas Venkataraman

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  1. Shrinivas Venkataraman
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Correspondence to Shrinivas Venkataraman .

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Editors and Affiliations

  1. Department of Bioengineering, University of Illinois at Urbana Champain, Urbana, Illinois, USA

    Dipanjan Pan

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Venkataraman, S. (2014). Rational Design of Multifunctional Nanoscale Self-Assembled Soft Materials for Biomedical Delivery Application. In: Pan, D. (eds) Personalized Medicine with a Nanochemistry Twist. Topics in Medicinal Chemistry, vol 20. Springer, Cham. https://doi.org/10.1007/7355_2014_76

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