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The Role of Smoothened and Hh Signaling in Neovascularization

  • Raffaella Soleti
  • Ramaroson Andriantsitohaina
  • Maria Carmen MartínezEmail author
Chapter
  • 539 Downloads
Part of the Topics in Medicinal Chemistry book series (TMC, volume 16)

Abstract

New vessel formation plays a key role not only in physiological processes such as embryonic development and wound repair but also during several pathological situations. In this respect, favoring neovascularization represents a promising therapeutic approach that would allow inducing tissue repair. Among the candidate proteins able to modulate neovascularization, evidence show that the administration of recombinant hedgehog (Hh) protein, gene, or cell therapy based on Hh transfer or using extracellular vesicles as vectors enhance new vessel formation. Here, we summarized the role of Hh pathway on angiogenesis and its therapeutic potential during myocardial infarction and diabetes.

Keywords

Extracellular vesicles Hedgehog Neovascularization Smoothened 

Abbreviations

AMPK

AMP-activated protein kinase

Ang(1, 2)

Angiopoietin(1, 2)

CECs

Circulating endothelial cells

Dhh

Desert hedgehog

ECM

Extracellular matrix

eNOS

Endothelial nitric oxide synthase

ERK

Extracellular signal-regulated kinase

FAK

Focal adhesion kinase

FGF

Fibroblast growth factor

Gli(1, 2, 3)

Glioma-associated oncogenes(1, 2, 3)

GPCR

G-protein-coupled receptors

Hh

Hedgehog

HIF-1

Hypoxia-inducible factor-1

Ihh

Indian hedgehog

iNOS

Inducible nitric oxide synthase

JNK

c-Jun N-terminal kinase

LGR5

Leucine-rich repeat G-protein-coupled receptor 5

LMPs

Lymphocytic microparticles

MAPK

Mitogen-activated protein kinase

miRs

MicroRNAs

MPs

Microparticles

MPsShh+

Microparticles expressing sonic hedgehog

mRNA

Messenger RNA

NO

Nitric oxide

PDGF

Platelet-derived growth factor

PECAM-1

Platelet-endothelial cell-adhesion molecule-1

phShh

Plasmid encoding the sonic hedgehog human gene

PI3K

Phosphatidylinositol 3-kinase

PKC

Protein kinase C

Ptc

Patched

ROCK

Rho-associated protein kinase

ROS

Reactive oxygen species

SDF-1

Stromal cell-derived factor-1

Shh

Sonic hedgehog

Smo

Smoothened

TGF-β

Transforming growth factor β

TSP1

Thrombospondin1

TYMP

Thymidine phosphorylase

VE-cadherin

Vascular endothelial cadherin

VEGF

Vascular endothelial growth factor

VEGFR(−1, −2)

Vascular endothelial growth factor receptor(−1, −2)

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Copyright information

© Springer International Publishing Switzerland 2014

Authors and Affiliations

  • Raffaella Soleti
    • 1
  • Ramaroson Andriantsitohaina
    • 1
    • 2
  • Maria Carmen Martínez
    • 1
    • 3
    Email author
  1. 1.INSERM UMR1063, Stress oxydant et pathologies métaboliquesAngersFrance
  2. 2.Centre Hospitalier Universitaire d’AngersAngersFrance
  3. 3.Institut de Biologie en SantéAngersFrance

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