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The Blood–Brain Barrier: An Introduction to Its Structure and Function

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The Blood Brain Barrier (BBB)

Part of the book series: Topics in Medicinal Chemistry ((TMC,volume 10))

Abstract

The blood-brain barrier (BBB) formed by the brains microvascular system is impermeable for most therapeutically used compounds and overcoming this barrier remains to be one of the big challenges in modern medicine. It is composed of highly specialized endothelial cells, which are surrounded by pericytes and a basal membrane. Together with nearby astrocytes and neurons they constitute the so-called neurovascular unit, which restricts substance transfer from blood to brain and vice versa and maintains the cerebral ion homeostasis. Chapters of this book describe the discovery of the BBB, its evolutionary development as well as the cellular and molecular mechanisms, which underlay its structure and function in health and disease. The organization of tight junctional complexes or specific transport processes at the BBB will be addressed as well as methods to investigate BBB function in vitro and in vivo. Changes in the barrier function under several diseases conditions such as stroke or inflammation will be discussed as well as approaches to overcome the barrier by colloidal carriers or ultrasound.

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Authors and Affiliations

  1. Institute of Pharmacy and Molecular Biotechnology, Ruprecht-Karls University, Im Neuenheimer Feld 366, 69120, Heidelberg, Germany

    Anne Mahringer, Melanie Ott & Gert Fricker

Authors
  1. Anne Mahringer
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  2. Melanie Ott
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  3. Gert Fricker
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Correspondence to Anne Mahringer .

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Editors and Affiliations

  1. Institut für Pharmazie und Molekulare Biotechnologie, Universität Heidelberg, Heidelberg, Baden-Württemberg, Germany

    Gert Fricker

  2. Dept. for Pharmaceutical Technology and Pharmacology, Institute für Pharmacy and Molecular Biotechnology, Heidelberg, Germany

    Melanie Ott

  3. Dept. for Pharmaceutical Technology and Pharmacology, Institute für Pharmacy and Molecular Biotechnology, Heidelberg, Germany

    Anne Mahringer

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Mahringer, A., Ott, M., Fricker, G. (2013). The Blood–Brain Barrier: An Introduction to Its Structure and Function. In: Fricker, G., Ott, M., Mahringer, A. (eds) The Blood Brain Barrier (BBB). Topics in Medicinal Chemistry, vol 10. Springer, Berlin, Heidelberg. https://doi.org/10.1007/7355_2013_20

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