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Glycine Transporters and Their Inhibitors

  • Robert GilfillanEmail author
  • Jennifer Kerr
  • Glenn Walker
  • Grant Wishart
Chapter
Part of the Topics in Medicinal Chemistry book series (TMC, volume 4)

Abstract

Glycine plays a ubiquitous role in many biological processes. In the central nervous systemit serves as an important neurotransmitter acting as an agonist at strychnine-sensitive glycine receptorsand as an essential co-agonist with glutamate at the NMDA receptor complex. Control of glycine concentrationsin the vicinity of these receptors is mediated by the specific glycine transporters, GlyT1 and GlyT2. Inhibitionof these transporters has been postulated to be of potential benefit in several therapeutic indicationsincluding schizophrenia and pain. In this review we discuss our current knowledge of glycine transportersand focus on recent advances in the medicinal chemistry of GlyT1 and GlyT2 inhibitors.

Glycine Glycine transporter inhibitor GlyT1 GlyT2 

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Copyright information

© Springer-Verlag Berlin Heidelberg 2009

Authors and Affiliations

  • Robert Gilfillan
    • 1
    Email author
  • Jennifer Kerr
    • 1
  • Glenn Walker
    • 1
  • Grant Wishart
    • 1
  1. 1.Schering Plough CorporationMotherwellUK

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