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Design of Monoamine Reuptake Inhibitors: SSRIs, SNRIs and NRIs

  • Gavin A. WhitlockEmail author
  • Mark D. Andrews
  • Alan D. Brown
  • Paul V. Fish
  • Alan Stobie
  • Florian Wakenhut
Chapter
Part of the Topics in Medicinal Chemistry book series (TMC, volume 4)

Abstract

This review will detail the medicinal chemistry involved in the design, synthesis and discovery ofselective serotonin, noradrenaline reuptake inhibitors and dual serotonin/noradrenaline reuptake inhibitors.In particular, this review will focus exclusively on series and compounds which have been disclosed withinthe medicinal chemistry literature between January 2000 and June 2008. Background information on previouslydisclosed clinical agents, such as atomoxetine, milnacipran and reboxetine, is included for comparison purposeswith more recently disclosed agents.

Dual reuptake inhibitor Design Monoamine NRI SAR SNRI SSRI 

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Copyright information

© Springer-Verlag Berlin Heidelberg 2008

Authors and Affiliations

  • Gavin A. Whitlock
    • 1
    Email author
  • Mark D. Andrews
    • 1
  • Alan D. Brown
    • 1
  • Paul V. Fish
    • 1
  • Alan Stobie
    • 1
  • Florian Wakenhut
    • 1
  1. 1.Pfizer Global R&DSandwichUK

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