Abstract
Current therapeutic drugs act on four main types of molecular targets: enzymes, receptors, ion channelsand transporters, among which a major part (60–70%) are membrane proteins. This review discussesthe molecular structures and potential impact of membrane transporter proteins on new drug discovery. Thethree-dimensional (3D) molecular structure of a protein contains information about the active siteand possible ligand binding, and about evolutionary relationships within the protein family. Transportershave a recognition site for a particular substrate, which may be used as a target for drugsinhibiting the transporter or acting as a false substrate. Three groups of transporters have particularinterest as drug targets: the major facilitator superfamily, which includes almost 4000 different proteinstransporting sugars, polyols, drugs, neurotransmitters, metabolites, amino acids, peptides, organic andinorganic anions and many other substrates; the ATP-binding cassette superfamily, which plays an importantrole in multidrug resistance in cancer chemotherapy; and the neurotransmitter:sodium symporter family, whichincludes the molecular targets for some of the most widely used psychotropic drugs. Recent technical advanceshave increased the number of known 3D structures of membrane transporters, and demonstrated that they forma divergent group of proteins with large conformational flexibility which facilitates transport ofthe substrate.
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References
Walian P, Cross TA, Jap BK (2004) Genome Biol 5:215
Klebe G (2006) Drug Discov Today 11:580
Blundell TL, Jhoti H, Abell C (2002) Nat Rev Drug Discov 1:45
Hajduk PJ, Greer J (2007) Nat Rev Drug Discov 6:211
Stoffler D, Sanner MF, Morris GM, Olson AJ, Goodsell DS (2002) Proteins 48:63
Tomasselli AG, Heinrikson RL (2000) Biochim Biophys Acta 1477:189
Elliott M (2001) Philos Trans R Soc Lond B Biol Sci 356:1885
Cushman DW, Ondetti MA, Gordon EM, Natarajan S, Karanewsky DS, Krapcho J, Petrillo EW Jr (1987) J Cardiovasc Pharmacol 10(7):S17
Fournie-Zaluski MC, Coric P, Thery V, Gonzalez W, Meudal H, Turcaud S, Michel JB, Roques BP (1996) J Med Chem 39:2594
Lundstrom K (2006) Cell Mol Life Sci 63:2597
Frishman D, Mewes HW (1997) Nat Struct Biol 4:626
Wallin E, von Heijne G (1998) Protein Sci 7:1029
Basyn F, Spies B, Bouffioux O, Thomas A, Brasseur R (2003) J Mol Graph Model 22:11
Elofsson A, von Heijne G (2007) Annu Rev Biochem
Oberai A, Ihm Y, Kim S, Bowie JU (2006) Protein Sci 15:1723
Amico M, Finelli M, Rossi I, Zauli A, Elofsson A, Viklund H, von Heijne G, Jones D, Krogh A, Fariselli P, Martelli PL, Casadio R (2006) Nucleic Acids Res 34:W169
Granseth E, Viklund H, Elofsson A (2006) Bioinformatics 22:e191
Viklund H, Granseth E, Elofsson A (2006) J Mol Biol 361:591
Saier MH Jr (2000) Microbiol Mol Biol Rev 64:354
Rothman RB, Silverthorn ML, Glowa JR, Matecka D, Rice KC, Carroll FI, Partilla JS, Uhl GR, Vandenbergh DJ, Dersch CM (1998) Synapse 28:322
Yamashita M, Fukushima S, Shen HW, Hall FS, Uhl GR, Numachi Y, Kobayashi H, Sora I (2006) Neuropsychopharmacology 31:2132
Race JE, Grassl SM, Williams WJ, Holtzman EJ (1999) Biochem Biophys Res Commun 255:508
Masereel B, Lohrmann E, Schynts M, Pirotte B, Greger R, Delarge J (1992) J Pharm Pharmacol 44:589
Diogo Filho A, Santos PS, Duque AS, Cezario RC, Gontijo Filho PP (2006) Acta Cir Bras 21:279
Dahl SG, Sylte I, Ravna AW (2004) J Pharmacol Exp Ther 309:853
Dassa E, Bouige P (2001) Res Microbiol 152:211
Dean M, Rzhetsky A, Allikmets R (2001) Genome Res 11:1156
Zhou F, You G (2007) Pharm Res 24:28
Caffrey M (2003) J Struct Biol 142:108
Cherezov V, Clogston J, Papiz MZ, Caffrey M (2006) J Mol Biol 357:1605
Cherezov V, Peddi A, Muthusubramaniam L, Zheng YF, Caffrey M (2004) Acta Crystallogr D Biol Crystallogr 60:1795
Eifler N, Duckely M, Sumanovski LT, Egan TM, Oksche A, Konopka JB, Luthi A, Engel A, Werten PJ (2007) J Struct Biol 159:179
Edwards AM, Arrowsmith CH, Christendat D, Dharamsi A, Friesen JD, Greenblatt JF, Vedadi M (2000) Nat Struct Biol 7:970
Turner GJ, Reusch R, Winter-Vann AM, Martinez L, Betlach MC (1999) Protein Expr Purif 17:312
Summers MD (2006) Adv Virus Res 68:3
Eifler N, Duckely M, Sumanovsky LT, Egan TM, Oksche A, Konopka JB, Luthi A, Engel A, Werten PJ (2007) J Struct Biol 159:179
Schurmann A, Keller K, Monden I, Brown FM, Wandel S, Shanahan MF, Joost HG (1993) Biochem J 290(Pt 2):497
Schurmann A, Monden I, Joost HG, Keller K (1992) Biochim Biophys Acta 1131:245
Garcia-Herrero A, Vogel HJ (2005) Mol Microbiol 58:1226
Kuhlbrandt W, Wang DN, Fujiyoshi Y (1994) Nature 367:614
Chiu ML, Nollert P, Loewen MC, Belrhali H, Pebay-Peyroula E, Rosenbusch JP, Landau EM (2000) Acta Crystallogr D Biol Crystallogr 56:781
Landau EM, Rosenbusch JP (1996) Proc Natl Acad Sci USA 93:14532
Nollert P, Qiu H, Caffrey M, Rosenbusch JP, Landau EM (2001) FEBS Lett 504:179
Faham S, Boulting GL, Massey EA, Yohannan S, Yang D, Bowie JU (2005) Protein Sci 14:836
Faham S, Bowie JU (2002) J Mol Biol 316:1
Page RC, Moore JD, Nguyen HB, Sharma M, Chase R, Gao FP, Mobley CK, Sanders CR, Ma L, Sonnichsen FD, Lee S, Howell SC, Opella SJ, Cross TA (2006) J Struct Funct Genomics 7:51
Kay LE (2005) J Magn Reson 173:193
Lian LY, Barsukov IL, Sutcliffe MJ, Sze KH, Roberts GC (1994) Methods Enzymol 239:657
Palmer AG III, Kroenke CD, Loria JP (2001) Methods Enzymol 339:204
Ratnala VR, Kiihne SR, Buda F, Leurs R, de Groot HJ, DeGrip WJ (2007) J Am Chem Soc 129:867
Rosenbusch JP (2001) J Struct Biol 136:144
Williams KA (2000) Nature 403:112
Wieman H, Tondel K, Anderssen E, Drablos F (2004) Mini Rev Med Chem 4:793
Kopp J, Schwede T (2004) Pharmacogenomics 5:405
Lundstrom K (2005) Trends Biotechnol 23:103
Dalton JA, Jackson RM (2007) Bioinformatics
Kopp J, Schwede T (2004) Nucleic Acids Res 32:D230
Kopp J, Schwede T (2006) Nucleic Acids Res 34:D315
Beuming T, Shi L, Javitch JA, Weinstein H (2006) Mol Pharmacol 70:1630
Burckhardt G, Wolff NA (2000) Am J Physiol Renal Physiol 278:F853
Lewinson O, Adler J, Sigal N, Bibi E (2006) Mol Microbiol 61:277
Smith FW, Rae AL, Hawkesford MJ (2000) Biochim Biophys Acta 1465:236
Tamura N, Konishi S, Yamaguchi A (2003) Curr Opin Chem Biol 7:570
Yamashita A, Singh SK, Kawate T, Jin Y, Gouaux E (2005) Nature 437:215
Jin J, Guffanti AA, Beck C, Krulwich TA (2001) J Bacteriol 183:2667
Wood NJ, Alizadeh T, Richardson DJ, Ferguson SJ, Moir JW (2002) Mol Microbiol 44:157
Marger MD, Saier MH Jr (1993) Trends Biochem Sci 18:13
Yin Y, He X, Szewczyk P, Nguyen T, Chang G (2006) Science 312:741
Huang Y, Lemieux MJ, Song J, Auer M, Wang DN (2003) Science 301:616
Abramson J, Smirnova I, Kasho V, Verner G, Kaback HR, Iwata S (2003) Science 301:610
Nishino K, Yamaguchi A (2001) J Bacteriol 183:5803
Saier MH Jr, Tam R, Reizer A, Reizer J (1994) Mol Microbiol 11:841
Murakami S, Nakashima R, Yamashita E, Yamaguchi A (2002) Nature 419:587
Murakami S, Nakashima R, Yamashita E, Matsumoto T, Yamaguchi A (2006) Nature 443:173
Seeger MA, Schiefner A, Eicher T, Verrey F, Diederichs K, Pos KM (2006) Science 313:1295
Yu EW, McDermott G, Zgurskaya HI, Nikaido H, Koshland DE Jr (2003) Science 300:976
Yu EW, Aires JR, McDermott G, Nikaido H (2005) J Bacteriol 187:6804
Sennhauser G, Amstutz P, Briand C, Storchenegger O, Grutter MG (2006) PLoS Biol 5:e7
Nikaido H, Zgurskaya HI (2001) J Mol Microbiol Biotechnol 3:215
Jack DL, Yang NM, Saier MH Jr (2001) Eur J Biochem 268:3620
Chung YJ, Saier MH Jr (2001) Curr Opin Drug Discov Devel 4:237
Ma C, Chang G (2004) Proc Natl Acad Sci USA 101:2852
Pornillos O, Chen YJ, Chen AP, Chang G (2005) Science 310:1950
Clark JA, Amara SG (1993) Bioessays 15:323
Zhang YW, Rudnick G (2006) J Biol Chem 281:36213
Yernool D, Boudker O, Jin Y, Gouaux E (2004) Nature 431:811
Boudker O, Ryan RM, Yernool D, Shimamoto K, Gouaux E (2007) Nature 445:387
Dawson RJ, Locher KP (2006) Nature 443:180
Chang G, Roth CB (2001) Science 293:1793
Chang G (2003) J Mol Biol 330:419
Reyes CL, Chang G (2005) Science 308:1028
Chang G, Roth CB, Reyes CL, Pornillos O, Chen YJ, Chen AP (2006) Science 314:1875
Locher KP, Lee AT, Rees DC (2002) Science 296:1091
Pinkett HW, Lee AT, Lum P, Locher KP, Rees DC (2007) Science 315:373
Dantzig AH, de Alwis DP, Burgess M (2003) Adv Drug Deliv Rev 55:133
Ejendal KF, Hrycyna CA (2002) Curr Protein Pept Sci 3:503
Leslie EM, Deeley RG, Cole SP (2005) Toxicol Appl Pharmacol 204:216
Ross DD, Doyle LA (2004) Cancer Cell 6:105
Sampath J, Adachi M, Hatse S, Naesens L, Balzarini J, Flatley RM, Matherly LH, Schuetz JD (2002) AAPS PharmSci 4:E14
Cordon-Cardo C, O'Brien JP, Casals D, Rittman-Grauer L, Biedler JL, Melamed MR, Bertino JR (1989) Proc Natl Acad Sci USA 86:695
McDevitt CA, Callaghan R (2007) Pharmacol Ther 113:429
Thomas H, Coley HM (2003) Cancer Control 10:159
Jedlitschky G, Burchell B, Keppler D (2000) J Biol Chem 275:30069
Belinsky MG, Bain LJ, Balsara BB, Testa JR, Kruh GD (1998) J Natl Cancer Inst 90:1735
Kool M, de Haas M, Scheffer GL, Scheper RJ, van Eijk MJ, Juijn JA, Baas F, Borst P (1997) Cancer Res 57:3537
McAleer MA, Breen MA, White NL, Matthews N (1999) J Biol Chem 274:23541
Nies AT, Spring H, Thon WF, Keppler D, Jedlitschky G (2002) J Urol 167:2271
Rius M, Thon WF, Keppler D, Nies AT (2005) J Urol 174:2409
Dazert P, Meissner K, Vogelgesang S, Heydrich B, Eckel L, Bohm M, Warzok R, Kerb R, Brinkmann U, Schaeffeler E, Schwab M, Cascorbi I, Jedlitschky G, Kroemer HK (2003) Am J Pathol 163:1567
Meyer Zu Schwabedissen HE, Grube M, Heydrich B, Linnemann K, Fusch C, Kroemer HK, Jedlitschky G (2005) Am J Pathol 166:39
Guthrie D, Isah H, Latner AL, Turner GA (1979) IRCS Med Sci 7:209
Turner GA, Ellis RD, Guthrie D, Latner AL, Monaghan JM, Ross WM, Skillen AW, Wilson RG (1982) J Clin Pathol 35:800
Luesley DM, Chan KK, Newton JR, Blackledge GR (1987) Br J Obstet Gynaecol 94:461
Turner GA, Ellis RD, Guthrie D, Latner AL, Ross WM, Skillen AW (1982) Br J Obstet Gynaecol 89:760
Turner GA, Greggi S, Guthrie D, Benedetti Panici P, Ellis RD, Scambia G, Mancuso S (1990) Eur J Gynaecol Oncol 11:421
Walker JE, Saraste M, Runswick MJ, Gay NJ (1982) Embo J 1:945
Muller M, Mayer R, Hero U, Keppler D (1994) FEBS Lett 343:168
Orlowski S, Garrigos M (1999) Anticancer Res 19:3109
Smit JW, Duin E, Steen H, Oosting R, Roggeveld J, Meijer DK (1998) Br J Pharmacol 123:361
Wang EJ, Lew K, Casciano CN, Clement RP, Johnson WW (2002) Antimicrob Agents Chemother 46:160
Sager G (2004) Neurochem Int 45:865
Ravna AW, Sylte I, Sager G (2007) Theor Biol Med Model 4:33
Alekshun MN, Levy SB (2007) Cell 128:1037
Li XZ, Zhang L, Nikaido H (2004) Antimicrob Agents Chemother 48:2415
Ables AZ, Baughman OL 3rd (2003) Am Fam Physician 67:547
Ravna AW, Edvardsen O (2001) J Mol Graph Model 20:133
Ravna AW, Sylte I, Dahl SG (2003) J Pharmacol Exp Ther 307:34
Ravna AW (2006) World J Biol Psychiatry 7:99
Ravna AW, Sylte I, Kristiansen K, Dahl SG (2006) Bioorg Med Chem 14:666
White KJ, Kiser PD, Nichols DE, Barker EL (2006) Protein Sci 15:2411
Ravna AW, Jaronczyk M, Sylte I (2006) Bioorg Med Chem Lett 16:5594
Abagyan R, Totrov M, Kuznetsov DN (1994) J Comput Chem 15:488
Bardo MT (1998) Crit Rev Neurobiol 12:37
Hall FS, Li XF, Sora I, Xu F, Caron M, Lesch KP, Murphy DL, Uhl GR (2002) Neuroscience 115:153
Uhl GR, Hall FS, Sora I (2002) Mol Psychiatry 7:21
Ravna AW, Sylte I, Dahl SG (2003) J Comput Aided Mol Des 17:367
Kitayama S, Shimada S, Xu H, Markham L, Donovan DM, Uhl GR (1992) Proc Natl Acad Sci USA 89:7782
Lee SH, Chang MY, Lee KH, Park BS, Lee YS, Chin HR (2000) Mol Pharmacol 57:883
Chen JG, Sachpatzidis A, Rudnick G (1997) J Biol Chem 272:28321
Hog S, Greenwood JR, Madsen KB, Larsson OM, Frolund B, Schousboe A, Krogsgaard-Larsen P, Clausen RP (2006) Curr Top Med Chem 6:1861
Schwartz TL, Nihalani N (2006) Expert Opin Pharmacother 7:1977
Sills GJ (2003) Epileptic Disord 5:51
Capuano A, Vollono C, Mei D, Pierguidi L, Ferraro D, Di Trapani G (2004) Clin Ter 155:79
Young AH, Geddes JR, Macritchie K, Rao SN, Vasudev A (2006) Cochrane Database Syst Rev 3:CD005173
Young AH, Geddes JR, Macritchie K, Rao SN, Watson S, Vasudev A (2006) Cochrane Database Syst Rev 3:CD004694
Depoortere R, Dargazanli G, Estenne-Bouhtou G, Coste A, Lanneau C, Desvignes C, Poncelet M, Heaulme M, Santucci V, Decobert M, Cudennec A, Voltz C, Boulay D, Terranova JP, Stemmelin J, Roger P, Marabout B, Sevrin M, Vige X, Biton B, Steinberg R, Francon D, Alonso R, Avenet P, Oury-Donat F, Perrault G, Griebel G, George P, Soubrie P, Scatton B (2005) Neuropsychopharmacology 30:1963
Lechner SM (2006) Curr Opin Pharmacol 6:75
Schuldiner S, Steiner-Mordoch S, Yelin R (1998) Adv Pharmacol 42:223
Fleckenstein AE, Volz TJ, Riddle EL, Gibb JW, Hanson GR (2007) Annu Rev Pharmacol Toxicol 47:681
Volz TJ, Fleckenstein AE, Hanson GR (2007) Addiction 102(1):44
Partilla JS, Dempsey AG, Nagpal AS, Blough BE, Baumann MH, Rothman RB (2006) J Pharmacol Exp Ther 319:237
Fleckenstein AE, Hanson GR (2003) Eur J Pharmacol 479:283
Riddle EL, Fleckenstein AE, Hanson GR (2005) AAPS J 7:E847
Hagenbuch B, Meier PJ (2004) Pflugers Arch 447:653
Meijer DK, Lennernas H (2005) Eur J Pharm Sci 26:130
Tirona RG, Leake BF, Merino G, Kim RB (2001) J Biol Chem 276:35669
Huber RD, Gao B, Sidler Pfandler MA, Zhang-Fu W, Leuthold S, Hagenbuch B, Folkers G, Meier PJ, Stieger B (2007) Am J Physiol Cell Physiol 292:C795
Brodin B, Nielsen CU, Steffansen B, Frokjaer S (2002) Pharmacol Toxicol 90:285
Vabeno J, Lejon T, Nielsen CU, Steffansen B, Chen W, Ouyang H, Borchardt RT, Luthman K (2004) J Med Chem 47:1060
Vabeno J, Nielsen CU, Ingebrigtsen T, Lejon T, Steffansen B, Luthman K (2004) J Med Chem 47:4755
Vabeno J, Nielsen CU, Steffansen B, Lejon T, Sylte I, Jorgensen FS, Luthman K (2005) Bioorg Med Chem 13:1977
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Ravna, A.W., Sager, G., Dahl, S.G., Sylte, I. (2008). Membrane Transporters: Structure, Function and Targets for Drug Design. In: Napier, S., Bingham, M. (eds) Transporters as Targets for Drugs. Topics in Medicinal Chemistry, vol 4. Springer, Berlin, Heidelberg. https://doi.org/10.1007/7355_2008_023
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